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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1369-MONOMER
UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase (EC:2.1.3.2)
Alternative name(s):
Aspartate transcarbamylase
Short name:
ATCase
Gene namesi
Name:pyrB
Ordered Locus Names:MTH_1413
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001132511 – 312Aspartate carbamoyltransferaseAdd BLAST312

Interactioni

Subunit structurei

Heterooligomer of catalytic and regulatory chains.By similarity

Protein-protein interaction databases

STRINGi187420.MTH1413

Structurei

3D structure databases

ProteinModelPortaliO27464
SMRiO27464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00911 Archaea
COG0540 LUCA
KOiK00609
OMAiWCDVANM
OrthoDBiPOG093Z05ID

Family and domain databases

Gene3Di3.40.50.13703 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

O27464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFENVISIKD FKREDIEFIL REAEKMEPFA SGEKSSSALR GKILGMMFYE
60 70 80 90 100
PSTRTRLSFE TAMKRLGGDV VGFADTGATS AVKGESLADT AMMLSAYSDA
110 120 130 140 150
IVIRHNLEGA ARYISDVVDV PVINAGDGAG QHPTQTLLDL YTMKRFFGRI
160 170 180 190 200
GSLRVALVGD LKYGRTVHSL AYALAVFGAS MSFVSPPVLR MPDNIIHDLR
210 220 230 240 250
RAGVEVKETE RLDDVIDEVD VLYVTRIQKE RFPDPEEYSR IRGAYHIDGS
260 270 280 290 300
TVADRDLIVM HPLPRIDEIS PEVDSLPQAM YFRQAFYGVP VRMALLRLLI
310
SERRGSENQK IV
Length:312
Mass (Da):34,872
Last modified:January 1, 1998 - v1
Checksum:i47F6BCC07A731D4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85890.1
PIRiC69055
RefSeqiWP_010877025.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85890; AAB85890; MTH_1413
GeneIDi1471130
KEGGimth:MTH_1413
PATRICifig|187420.15.peg.1377

Similar proteinsi

Entry informationi

Entry nameiPYRB_METTH
AccessioniPrimary (citable) accession number: O27464
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome