O27447 (THIL_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable thiamine-monophosphate kinase
Short name=Thiamine-phosphate kinase
EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	MTH_1396

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamine-phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Probable thiamine-monophosphate kinase		PRO_0000096202

Sequences

	Sequence		Length	Mass (Da)
	O27447 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 93DF81DAFD1A4FC3	FASTA	327	35,012
	10 20 30 40 50 60 MHDRISSLGE KKLISRIISR ARSVFGSSEV MGLGDDAALI DAGEEFLVLT SDLLLETRHF 70 80 90 100 110 120 PDPERPRDMG WKTVTVNMSD LAAMGSRPEG FILSVALPDL ELEFFDSLMD GVIEACCHYQ 130 140 150 160 170 180 APLIGGDTNE ADEIILSGTA IGRAEKDMVL MKSGARPGDL VAVTGPLGVG AAGTELILSG 190 200 210 220 230 240 RDTGGFENAV ERSLRPVARI EEGLILAESG LVSSATDITD GLVSELGELM DASGTGMRIY 250 260 270 280 290 300 EDRLPLGREV PEIASILGRD PLELALYYGE DFELVFTAPP TGMEELSDMM ELHVIGEVTV 310 320 GGGIEMVDKD GVTYKLHVRG YEHLSPG

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85873.1.
PIR	G69052.
RefSeq	NP_276512.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O27447.
ModBase	Search...
Protein-protein interaction databases
STRING	O27447.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1471113.
GenomeReviews	Gene locus MTH_1396 in contig AE000666_GR.
KEGG	mth:MTH1396.
NMPDR	fig|187420.1.peg.1367.
Phylogenomic databases
eggNOG	arNOG09501.
HOGENOM	HBG577902.
OMA	MGAEPAW.
PhylomeDB	O27447.
ProtClustDB	CLSK798158.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH1396-MONOMER.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR006283. ThiL. [Graphical view]
KO	K00946.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR01379. ThiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_METTH

Accession

Primary (citable) accession number: O27447

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program