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O27397

- OGG1_METTH

UniProt

O27397 - OGG1_METTH

Protein

Probable N-glycosylase/DNA lyase

Gene

MTH_1342

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion By similarity.By similarity

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei235 – 2351By similarity

    GO - Molecular functioni

    1. damaged DNA binding Source: InterPro
    2. oxidized purine nucleobase lesion DNA N-glycosylase activity Source: InterPro

    GO - Biological processi

    1. base-excision repair Source: InterPro
    2. nucleotide-excision repair Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-1344-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyase
    Including the following 2 domains:
    8-oxoguanine DNA glycosylase (EC:3.2.2.-)
    DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
    Short name:
    AP lyase
    Gene namesi
    Ordered Locus Names:MTH_1342
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Probable N-glycosylase/DNA lyasePRO_0000058596Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH1342.

    Structurei

    3D structure databases

    ProteinModelPortaliO27397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-1 OGG1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0122.
    KOiK03660.
    OMAiLCYDRKT.

    Family and domain databases

    Gene3Di1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    InterProiIPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR023170. HTH_base_excis_C.
    IPR004577. Ogg.
    IPR012904. OGG_N.
    [Graphical view]
    PfamiPF00730. HhH-GPD. 1 hit.
    PF07934. OGG_N. 1 hit.
    [Graphical view]
    SMARTiSM00478. ENDO3c. 1 hit.
    SM00278. HhH1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.
    TIGRFAMsiTIGR00588. ogg. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O27397-1 [UniParc]FASTAAdd to Basket

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    MRIPVGDFDL EMTQRSGQTS QPPWREVEGA FRELLIIEGV PCPVEVRNEA    50
    GVLRVRPYVD VPQKTLREKI EYIFDLKFDI EDFYTFLEDK NLSYTLDSSR 100
    GLRLFLAKDP FECVISSIAS ANCSVVRWTR SIEDIRRLWG QANTFNGETF 150
    HTFPSPHVLT GVAEGSLEDL QRAEDNLPSD FSFNDLRSCG VGYRAPYIRE 200
    TSRILAEEMD IRRIDGMDYD DARELLLELS GVGPKVADCI LLYGFRKTEA 250
    FPVDVWIRRI MNHIHPGRNF NDRSMVEFAR REYGEMADYV QLYLFNHARR 300
    SGLLDRLRQG TG 312
    Length:312
    Mass (Da):36,052
    Last modified:January 1, 1998 - v1
    Checksum:iD33B4FF497BC5A1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85820.1.
    PIRiE69045.
    RefSeqiNP_276459.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB85820; AAB85820; MTH_1342.
    GeneIDi1471059.
    KEGGimth:MTH1342.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85820.1 .
    PIRi E69045.
    RefSeqi NP_276459.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O27397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH1342.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB85820 ; AAB85820 ; MTH_1342 .
    GeneIDi 1471059.
    KEGGi mth:MTH1342.

    Phylogenomic databases

    eggNOGi COG0122.
    KOi K03660.
    OMAi LCYDRKT.

    Enzyme and pathway databases

    BioCyci MTHE187420:GJNM-1344-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    InterProi IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR023170. HTH_base_excis_C.
    IPR004577. Ogg.
    IPR012904. OGG_N.
    [Graphical view ]
    Pfami PF00730. HhH-GPD. 1 hit.
    PF07934. OGG_N. 1 hit.
    [Graphical view ]
    SMARTi SM00478. ENDO3c. 1 hit.
    SM00278. HhH1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    TIGRFAMsi TIGR00588. ogg. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiOGG1_METTH
    AccessioniPrimary (citable) accession number: O27397
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3