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Protein

Probable N-glycosylase/DNA lyase

Gene

MTH_1342

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion (By similarity).By similarity

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei235By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1299-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Ordered Locus Names:MTH_1342
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585961 – 312Probable N-glycosylase/DNA lyaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1342

Structurei

3D structure databases

ProteinModelPortaliO27397
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-1 OGG1 family.Curated

Phylogenomic databases

eggNOGiarCOG00464 Archaea
COG0122 LUCA
KOiK03660
OMAiYLWRSIE
OrthoDBiPOG093Z060W

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
InterProiView protein in InterPro
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR000445 HhH_motif
IPR004577 Ogg1
IPR012904 OGG_N
PfamiView protein in Pfam
PF00633 HHH, 1 hit
PF00730 HhH-GPD, 1 hit
PF07934 OGG_N, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit
TIGRFAMsiTIGR00588 ogg, 1 hit

Sequencei

Sequence statusi: Complete.

O27397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIPVGDFDL EMTQRSGQTS QPPWREVEGA FRELLIIEGV PCPVEVRNEA
60 70 80 90 100
GVLRVRPYVD VPQKTLREKI EYIFDLKFDI EDFYTFLEDK NLSYTLDSSR
110 120 130 140 150
GLRLFLAKDP FECVISSIAS ANCSVVRWTR SIEDIRRLWG QANTFNGETF
160 170 180 190 200
HTFPSPHVLT GVAEGSLEDL QRAEDNLPSD FSFNDLRSCG VGYRAPYIRE
210 220 230 240 250
TSRILAEEMD IRRIDGMDYD DARELLLELS GVGPKVADCI LLYGFRKTEA
260 270 280 290 300
FPVDVWIRRI MNHIHPGRNF NDRSMVEFAR REYGEMADYV QLYLFNHARR
310
SGLLDRLRQG TG
Length:312
Mass (Da):36,052
Last modified:January 1, 1998 - v1
Checksum:iD33B4FF497BC5A1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85820.1
PIRiE69045
RefSeqiWP_010876955.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85820; AAB85820; MTH_1342
GeneIDi1471059
KEGGimth:MTH_1342

Similar proteinsi

Entry informationi

Entry nameiOGG1_METTH
AccessioniPrimary (citable) accession number: O27397
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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