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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity). In conjunction with replication factor C (RFC) stimulates DNA synthesis by PolB, relieving inhibition by replication protein A (RPA).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1270-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:MTH_1312
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492001 – 244DNA polymerase sliding clampAdd BLAST244

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi187420.MTH1312

Structurei

3D structure databases

ProteinModelPortaliO27367
SMRiO27367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
KOiK04802
OMAiKCANSDD
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

O27367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKAELNDPN ILRTSFDAIS SIVDEVQIQL SAEGLRLDAL DRSHITYVHL
60 70 80 90 100
ELKAELFDEY VCDEPERINV DTEELMKVLK RAKANDRVIL STDEGNLIIQ
110 120 130 140 150
FEGEAVRTFK IRLIDIEYET PSPPEIEYEN EFEVPFQLLK DSIADIDIFS
160 170 180 190 200
DKITFRVDED RFIASAEGEF GDAQIEYLHG ERIDKPARSI YSLDKIKEML
210 220 230 240
KADKFSETAI INLGDDMPLK LTLKMASKEG ELSFLLAPRI EAEE
Length:244
Mass (Da):27,969
Last modified:January 1, 1998 - v1
Checksum:iCCE44AAE59139CB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85790.1
PIRiD69041
RefSeqiWP_010876925.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85790; AAB85790; MTH_1312
GeneIDi1471029
KEGGimth:MTH_1312
PATRICifig|187420.15.peg.1281

Similar proteinsi

Entry informationi

Entry nameiPCNA_METTH
AccessioniPrimary (citable) accession number: O27367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health