O27272 (PUR5_METTH) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 78.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Alternative name(s): AIR synthase AIRS Phosphoribosyl-aminoimidazole synthetase | ||||
| Gene names |
| ||||
| Organism | Methanobacterium thermoautotrophicum (strain Delta H) | ||||
| Taxonomic identifier | 187420 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter |
Protein attributes
| Sequence length | 338 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_A |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_A |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00741_A. |
| Sequence similarities | Belongs to the AIR synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 338 | 338 | Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_A | PRO_0000148284 | |||
Sequences
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References
| [1] | "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. Reeve J.N.J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000666 Genomic DNA. Translation: AAB85693.1. |
| PIR | G69027. |
| RefSeq | NP_276332.1. NC_000916.1. |
3D structure databases | |
| ProteinModelPortal | O27272. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O27272. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1471612. |
| GenomeReviews | Gene locus MTH_1204 in contig AE000666_GR. |
| KEGG | mth:MTH1204. |
| NMPDR | fig|187420.1.peg.1187. |
Phylogenomic databases | |
| eggNOG | arNOG04189. |
| HOGENOM | HBG531222. |
| OMA | GIDMIAM. |
| PhylomeDB | O27272. |
| ProtClustDB | PRK05385. |
Enzyme and pathway databases | |
| BioCyc | MTHE187420:MTH1204-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00741_A. AIRS_A. [Tree] |
| InterPro | IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view] |
| KO | K01933. |
| Pfam | PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view] |
| SUPFAM | SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit. |
| TIGRFAMs | TIGR00878. PurM. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR5_METTH | ||||||||
| Accession | Primary (citable) accession number: O27272 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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