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O27272

- PUR5_METTH

UniProt

O27272 - PUR5_METTH

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-1206-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
    Alternative name(s):
    AIR synthase
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    Gene namesi
    Name:purM
    Ordered Locus Names:MTH_1204
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148284Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH1204.

    Structurei

    3D structure databases

    ProteinModelPortaliO27272.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0150.
    KOiK01933.
    OMAiVIGKIEH.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_A. AIRS_A.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O27272-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTYSESGVD IDLEELTVSS LTSRLSDTLK YCDVITGAGH FAALVRMGDV    50
    AIAMSTDGVG SKILVAEMMN RYDTVGIDCI AMVVNDILCV GARPAALVDY 100
    LAVERPDPEV AGEIGKGLAM GAEMARVAII GGETASLPGI IRNLDLAATG 150
    IGFVDVDRII TGEDVSPGDT VIGLESSGIH SNGLSLARRV FFDELELSPE 200
    DEMPGSSSSV GDELLRPTRI YVEPIMELIE SDVDVHGLAH ITGGGFGNLK 250
    RLRKDVGYRL DSLPEPQQIF RVIHEAGVDI REMYRVFNMG VGFCAVVAPD 300
    DVDEALSILG DRAHPIGEVT DRGSEVELEA CTGETIKL 338
    Length:338
    Mass (Da):35,983
    Last modified:January 1, 1998 - v1
    Checksum:i5C6AA2B6562E0E17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85693.1.
    PIRiG69027.
    RefSeqiNP_276332.1. NC_000916.1.
    WP_010876828.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB85693; AAB85693; MTH_1204.
    GeneIDi1471612.
    KEGGimth:MTH1204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85693.1 .
    PIRi G69027.
    RefSeqi NP_276332.1. NC_000916.1.
    WP_010876828.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O27272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH1204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB85693 ; AAB85693 ; MTH_1204 .
    GeneIDi 1471612.
    KEGGi mth:MTH1204.

    Phylogenomic databases

    eggNOGi COG0150.
    KOi K01933.
    OMAi VIGKIEH.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci MTHE187420:GJNM-1206-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_A. AIRS_A.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiPUR5_METTH
    AccessioniPrimary (citable) accession number: O27272
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3