ID   DGGGP_METTH             Reviewed;         281 AA.
AC   O27170;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 110.
DE   RecName: Full=Digeranylgeranylglyceryl phosphate synthase;
DE            Short=DGGGP synthase;
DE            Short=DGGGPS;
DE            EC=2.5.1.42;
DE   AltName: Full=(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase;
DE   AltName: Full=Geranylgeranylglycerol-phosphate geranylgeranyltransferase;
GN   OrderedLocusNames=MTH_1098;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
RN   [2]
RP   FUNCTION, CATALYTIC ACTIVITY, AND SUBCELLULAR LOCATION.
RC   STRAIN=Marburg / DSM 2133;
RA   Zhang D., Poulter C.D.;
RT   "Biosynthesis of archaebacterial ether lipids. Formation of ether linkages
RT   by prenyltransferases.";
RL   J. Am. Chem. Soc. 115:1270-1277(1993).
CC   -!- FUNCTION: Prenyltransferase that catalyzes the transfer of the
CC       geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2
CC       hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This
CC       reaction is the second ether-bond-formation step in the biosynthesis of
CC       archaeal membrane lipids. {ECO:0000269|Ref.2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-
CC         (geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-
CC         glycerol 1-phosphate + diphosphate; Xref=Rhea:RHEA:18109,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57677, ChEBI:CHEBI:58756,
CC         ChEBI:CHEBI:58837; EC=2.5.1.42; Evidence={ECO:0000269|Ref.2};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|Ref.2}; Multi-pass
CC       membrane protein {ECO:0000269|Ref.2}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family. DGGGP
CC       synthase subfamily. {ECO:0000305}.
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DR   EMBL; AE000666; AAB85587.1; -; Genomic_DNA.
DR   PIR; H69012; H69012.
DR   RefSeq; WP_010876722.1; NC_000916.1.
DR   AlphaFoldDB; O27170; -.
DR   SMR; O27170; -.
DR   STRING; 187420.MTH_1098; -.
DR   PaxDb; 187420-MTH_1098; -.
DR   EnsemblBacteria; AAB85587; AAB85587; MTH_1098.
DR   GeneID; 77401629; -.
DR   KEGG; mth:MTH_1098; -.
DR   PATRIC; fig|187420.15.peg.1076; -.
DR   HOGENOM; CLU_073311_1_1_2; -.
DR   InParanoid; O27170; -.
DR   BioCyc; MetaCyc:MONOMER-14509; -.
DR   UniPathway; UPA00940; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0047295; F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006650; P:glycerophospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd13961; PT_UbiA_DGGGPS; 1.
DR   Gene3D; 1.10.357.140; UbiA prenyltransferase; 1.
DR   Gene3D; 1.20.120.1780; UbiA prenyltransferase; 1.
DR   HAMAP; MF_01286; DGGGP_synth; 1.
DR   InterPro; IPR023547; DGGGP_synth.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR044878; UbiA_sf.
DR   PANTHER; PTHR42723; CHLOROPHYLL SYNTHASE; 1.
DR   PANTHER; PTHR42723:SF1; CHLOROPHYLL SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF01040; UbiA; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..281
FT                   /note="Digeranylgeranylglyceryl phosphate synthase"
FT                   /id="PRO_0000350692"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  30132 MW;  E6661FE221C85278 CRC64;
     MNPYIEILRP VNAVMAVITV MLMALITGRF DFSVLLASVV VFTATGAGNV INDYFDHEID
     AINRPERPIP SGRISRGVAG VYSIILFALA SLMGFYLGLL PGLVVVSSSL LMVYYAWRLK
     KRCLVGNITI SFLTGLSFVF GGIVLGEVRA SILLGFYAFL MTMAREIVKD MEDVEGDRAE
     GATTLPITHG MRISGVLAAS FMLIASLTSP SLYLLGIFSA LYIPVLLLAV AVFLRAAIMI
     LRGQDRATAS RVSRMIKVGM ALTFIAFAAG SGTITALTGL S
//