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Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

MTH_1098

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.1 Publication

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.1 Publication

Cofactori

Mg2+By similarity

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14509.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthase (EC:2.5.1.42)
Short name:
DGGGP synthase
Short name:
DGGGPS
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
Geranylgeranylglycerol-phosphate geranylgeranyltransferase
Gene namesi
Ordered Locus Names:MTH_1098
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei72 – 91HelicalSequence analysisAdd BLAST20
Transmembranei95 – 117HelicalSequence analysisAdd BLAST23
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003506921 – 281Digeranylgeranylglyceryl phosphate synthaseAdd BLAST281

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1098.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
KOiK17105.
OMAiNCITASF.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O27170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPYIEILRP VNAVMAVITV MLMALITGRF DFSVLLASVV VFTATGAGNV
60 70 80 90 100
INDYFDHEID AINRPERPIP SGRISRGVAG VYSIILFALA SLMGFYLGLL
110 120 130 140 150
PGLVVVSSSL LMVYYAWRLK KRCLVGNITI SFLTGLSFVF GGIVLGEVRA
160 170 180 190 200
SILLGFYAFL MTMAREIVKD MEDVEGDRAE GATTLPITHG MRISGVLAAS
210 220 230 240 250
FMLIASLTSP SLYLLGIFSA LYIPVLLLAV AVFLRAAIMI LRGQDRATAS
260 270 280
RVSRMIKVGM ALTFIAFAAG SGTITALTGL S
Length:281
Mass (Da):30,132
Last modified:January 1, 1998 - v1
Checksum:iE6661FE221C85278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85587.1.
PIRiH69012.
RefSeqiWP_010876722.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85587; AAB85587; MTH_1098.
GeneIDi1471506.
KEGGimth:MTH_1098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85587.1.
PIRiH69012.
RefSeqiWP_010876722.1. NC_000916.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85587; AAB85587; MTH_1098.
GeneIDi1471506.
KEGGimth:MTH_1098.

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
KOiK17105.
OMAiNCITASF.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciMetaCyc:MONOMER-14509.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGGGP_METTH
AccessioniPrimary (citable) accession number: O27170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.