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O27170

- DGGGP_METTH

UniProt

O27170 - DGGGP_METTH

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Protein
Digeranylgeranylglyceryl phosphate synthase
Gene
MTH_1098
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.1 Publication

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.1 Publication

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. geranylgeranylglycerol-phosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. prenyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
  2. phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14509.
MTHE187420:GJNM-1100-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthase (EC:2.5.1.42)
Short name:
DGGGP synthase
Short name:
DGGGPS
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
Geranylgeranylglycerol-phosphate geranylgeranyltransferase
Gene namesi
Ordered Locus Names:MTH_1098
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei32 – 5221Helical; Reviewed prediction
Add
BLAST
Transmembranei72 – 9120Helical; Reviewed prediction
Add
BLAST
Transmembranei95 – 11723Helical; Reviewed prediction
Add
BLAST
Transmembranei128 – 14821Helical; Reviewed prediction
Add
BLAST
Transmembranei193 – 21321Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei258 – 27821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Digeranylgeranylglyceryl phosphate synthaseUniRule annotation
PRO_0000350692Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1098.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0382.
KOiK17105.
OMAiNCITASF.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O27170-1 [UniParc]FASTAAdd to Basket

« Hide

MNPYIEILRP VNAVMAVITV MLMALITGRF DFSVLLASVV VFTATGAGNV    50
INDYFDHEID AINRPERPIP SGRISRGVAG VYSIILFALA SLMGFYLGLL 100
PGLVVVSSSL LMVYYAWRLK KRCLVGNITI SFLTGLSFVF GGIVLGEVRA 150
SILLGFYAFL MTMAREIVKD MEDVEGDRAE GATTLPITHG MRISGVLAAS 200
FMLIASLTSP SLYLLGIFSA LYIPVLLLAV AVFLRAAIMI LRGQDRATAS 250
RVSRMIKVGM ALTFIAFAAG SGTITALTGL S 281
Length:281
Mass (Da):30,132
Last modified:January 1, 1998 - v1
Checksum:iE6661FE221C85278
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB85587.1.
PIRiH69012.
RefSeqiNP_276226.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85587; AAB85587; MTH_1098.
GeneIDi1471506.
KEGGimth:MTH1098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB85587.1 .
PIRi H69012.
RefSeqi NP_276226.1. NC_000916.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 187420.MTH1098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB85587 ; AAB85587 ; MTH_1098 .
GeneIDi 1471506.
KEGGi mth:MTH1098.

Phylogenomic databases

eggNOGi COG0382.
KOi K17105.
OMAi NCITASF.

Enzyme and pathway databases

UniPathwayi UPA00940 .
BioCyci MetaCyc:MONOMER-14509.
MTHE187420:GJNM-1100-MONOMER.

Family and domain databases

HAMAPi MF_01286. DGGGP_synth.
InterProi IPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view ]
Pfami PF01040. UbiA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. "Biosynthesis of archaebacterial ether lipids. Formation of ether linkages by prenyltransferases."
    Zhang D., Poulter C.D.
    J. Am. Chem. Soc. 115:1270-1277(1993)
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    Strain: Marburg / DSM 2133.

Entry informationi

Entry nameiDGGGP_METTH
AccessioniPrimary (citable) accession number: O27170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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