Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O27170

- DGGGP_METTH

UniProt

O27170 - DGGGP_METTH

Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

MTH_1098

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.1 Publication

    Catalytic activityi

    Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.1 Publication

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranylglycerol-phosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. prenyltransferase activity Source: InterPro

    GO - Biological processi

    1. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
    2. phospholipid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14509.
    MTHE187420:GJNM-1100-MONOMER.
    UniPathwayiUPA00940.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Digeranylgeranylglyceryl phosphate synthase (EC:2.5.1.42)
    Short name:
    DGGGP synthase
    Short name:
    DGGGPS
    Alternative name(s):
    (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
    Geranylgeranylglycerol-phosphate geranylgeranyltransferase
    Gene namesi
    Ordered Locus Names:MTH_1098
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Digeranylgeranylglyceryl phosphate synthasePRO_0000350692Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH1098.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0382.
    KOiK17105.
    OMAiNCITASF.

    Family and domain databases

    HAMAPiMF_01286. DGGGP_synth.
    InterProiIPR023547. DGGGP_synth.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view]
    PfamiPF01040. UbiA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O27170-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPYIEILRP VNAVMAVITV MLMALITGRF DFSVLLASVV VFTATGAGNV    50
    INDYFDHEID AINRPERPIP SGRISRGVAG VYSIILFALA SLMGFYLGLL 100
    PGLVVVSSSL LMVYYAWRLK KRCLVGNITI SFLTGLSFVF GGIVLGEVRA 150
    SILLGFYAFL MTMAREIVKD MEDVEGDRAE GATTLPITHG MRISGVLAAS 200
    FMLIASLTSP SLYLLGIFSA LYIPVLLLAV AVFLRAAIMI LRGQDRATAS 250
    RVSRMIKVGM ALTFIAFAAG SGTITALTGL S 281
    Length:281
    Mass (Da):30,132
    Last modified:January 1, 1998 - v1
    Checksum:iE6661FE221C85278
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85587.1.
    PIRiH69012.
    RefSeqiNP_276226.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB85587; AAB85587; MTH_1098.
    GeneIDi1471506.
    KEGGimth:MTH1098.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85587.1 .
    PIRi H69012.
    RefSeqi NP_276226.1. NC_000916.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH1098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB85587 ; AAB85587 ; MTH_1098 .
    GeneIDi 1471506.
    KEGGi mth:MTH1098.

    Phylogenomic databases

    eggNOGi COG0382.
    KOi K17105.
    OMAi NCITASF.

    Enzyme and pathway databases

    UniPathwayi UPA00940 .
    BioCyci MetaCyc:MONOMER-14509.
    MTHE187420:GJNM-1100-MONOMER.

    Family and domain databases

    HAMAPi MF_01286. DGGGP_synth.
    InterProi IPR023547. DGGGP_synth.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view ]
    Pfami PF01040. UbiA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
    2. "Biosynthesis of archaebacterial ether lipids. Formation of ether linkages by prenyltransferases."
      Zhang D., Poulter C.D.
      J. Am. Chem. Soc. 115:1270-1277(1993)
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
      Strain: Marburg / DSM 2133.

    Entry informationi

    Entry nameiDGGGP_METTH
    AccessioniPrimary (citable) accession number: O27170
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3