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Protein

Elongation factor 2

Gene

fusA

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi94 – 98GTPBy similarity5
Nucleotide bindingi148 – 151GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1019-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 2
Short name:
EF-2
Gene namesi
Name:fusA
Synonyms:fus
Ordered Locus Names:MTH_1057
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000910371 – 730Elongation factor 2Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei597DiphthamideBy similarity1

Proteomic databases

PRIDEiO27131

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1057

Structurei

3D structure databases

ProteinModelPortaliO27131
SMRiO27131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 260tr-type GAdd BLAST242

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01559 Archaea
COG0480 LUCA
KOiK03234
OMAiEHLISGM
OrthoDBiPOG093Z00HF

Family and domain databases

Gene3Di3.30.230.102 hits
HAMAPiMF_00054_A EF_G_EF_2_A, 1 hit
InterProiView protein in InterPro
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR004543 Transl_elong_EFG/EF2_arc
IPR005517 Transl_elong_EFG/EF2_IV
PfamiView protein in Pfam
PF00679 EFG_C, 1 hit
PF03764 EFG_IV, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SMARTiView protein in SMART
SM00838 EFG_C, 1 hit
SM00889 EFG_IV, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF54980 SSF54980, 2 hits
TIGRFAMsiTIGR00490 aEF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O27131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRAKMISK IKELMYQPEY IRNIGIVAHI DHGKTTLSDN LLAGAGMISA
60 70 80 90 100
ELAGDQRFLD FDEQEQARGI TIDAANVSMV HSYEGNEYLI NLIDTPGHVD
110 120 130 140 150
FGGDVTRAMR AVDGAVVVVC AVEGIMPQTE TVLRQALKEN VRPVLFINKV
160 170 180 190 200
DRLINELKLD ASELQERFVK IIANANKLIK NMAPEEFRDK WQVRVEDGSV
210 220 230 240 250
AFGSAYHNWA INVPIMQETG INFNDIYKYC TEDNQKELAQ KVPLHQVLLG
260 270 280 290 300
MVVEHLPSPA ESQAYRVPII WSGDLESEEG QAMLKTDPEG PLAVMVTDVS
310 320 330 340 350
IDKHAGEVAT GRVYGGAIEK GSEVFLVGSH SKARVQQVGV YMGPERVNTD
360 370 380 390 400
KVPAGNIVAI TGAKNAVAGE TICDTGRKIK AFEGLEHISE PVVTVAVEAK
410 420 430 440 450
NTKDLPKLIE VLRQVGKEDP TVRVEINEET GEHLISGMGE LHLEIIAYRI
460 470 480 490 500
NEKGVEIETS EPIVVYRETV AGTAGPVEGK SPNKHNRFYI EIEPVEASVM
510 520 530 540 550
QAIQEGKIKE GRVKGKEMAK NFIEAGMDKE EARRVWDVYE KNLFINMTRG
560 570 580 590 600
IQYLDEIKEL LMDGFESAMD NGPVAKEKVM GVKIKLMDAK IHEDAVHRGP
610 620 630 640 650
AQVLPAIRKG IFGAMMSAEP VLLEPIQKVF INVPQDYMGS ATREIQNRRG
660 670 680 690 700
QIVNMTQEGD MVTVESTVPV AEMFGFAGDI RSATEGRCLW STENAGFERL
710 720 730
PNELQHTITR EVRTRKGLSP EPYRADHYLG
Length:730
Mass (Da):80,924
Last modified:May 30, 2000 - v2
Checksum:i07549350848DE81C
GO

Sequence cautioni

The sequence AAB85548 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85548.1 Different initiation.
PIRiE69007
RefSeqiWP_048060960.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85548; AAB85548; MTH_1057
GeneIDi1471465
KEGGimth:MTH_1057
PATRICifig|187420.15.peg.1036

Similar proteinsi

Entry informationi

Entry nameiEF2_METTH
AccessioniPrimary (citable) accession number: O27131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome