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Protein

DNA-directed RNA polymerase subunit H

Gene

rpoH

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit HUniRule annotation (EC:2.7.7.6UniRule annotation)
Alternative name(s):
RPB5
Gene namesi
Name:rpoHUniRule annotation
Ordered Locus Names:MTH_1048
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7777DNA-directed RNA polymerase subunit HPRO_0000146096Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1048.

Structurei

Secondary structure

1
77
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 104Combined sources
Beta strandi13 – 175Combined sources
Helixi19 – 2810Combined sources
Turni33 – 353Combined sources
Helixi44 – 474Combined sources
Helixi48 – 503Combined sources
Beta strandi56 – 638Combined sources
Turni64 – 663Combined sources
Beta strandi67 – 748Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EIKNMR-A1-77[»]
ProteinModelPortaliO27122.
SMRiO27122. Positions 1-77.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO27122.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04258. Archaea.
COG2012. LUCA.
KOiK03053.
OMAiDHILVPK.

Family and domain databases

Gene3Di3.90.940.20. 1 hit.
HAMAPiMF_00025. RNApol_RpoH_RPB5. 1 hit.
InterProiIPR000783. RNA_pol_subH/Rpb5_C.
IPR020608. RNA_pol_subH/Rpb5_CS.
IPR020609. RpoH/RPB5.
[Graphical view]
PfamiPF01191. RNA_pol_Rpb5_C. 1 hit.
[Graphical view]
ProDomiPD005155. RNA_pol_subH/Rpb5_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55287. SSF55287. 1 hit.
PROSITEiPS01110. RNA_POL_H_23KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O27122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKREILKHQL VPEHVILNES EAKRVLKELD AHPEQLPKIK TTDPVAKAIG
60 70
AKRGDIVKII RKSPTAEEFV TYRLVQD
Length:77
Mass (Da):8,808
Last modified:January 1, 1998 - v1
Checksum:i745435E11D2756DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85539.1.
PIRiC69006.
RefSeqiWP_010876674.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85539; AAB85539; MTH_1048.
GeneIDi1471456.
KEGGimth:MTH_1048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85539.1.
PIRiC69006.
RefSeqiWP_010876674.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EIKNMR-A1-77[»]
ProteinModelPortaliO27122.
SMRiO27122. Positions 1-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1048.

Protocols and materials databases

DNASUi1471456.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85539; AAB85539; MTH_1048.
GeneIDi1471456.
KEGGimth:MTH_1048.

Phylogenomic databases

eggNOGiarCOG04258. Archaea.
COG2012. LUCA.
KOiK03053.
OMAiDHILVPK.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1050-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO27122.

Family and domain databases

Gene3Di3.90.940.20. 1 hit.
HAMAPiMF_00025. RNApol_RpoH_RPB5. 1 hit.
InterProiIPR000783. RNA_pol_subH/Rpb5_C.
IPR020608. RNA_pol_subH/Rpb5_CS.
IPR020609. RpoH/RPB5.
[Graphical view]
PfamiPF01191. RNA_pol_Rpb5_C. 1 hit.
[Graphical view]
ProDomiPD005155. RNA_pol_subH/Rpb5_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55287. SSF55287. 1 hit.
PROSITEiPS01110. RNA_POL_H_23KD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOH_METTH
AccessioniPrimary (citable) accession number: O27122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.