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O27122

- RPOH_METTH

UniProt

O27122 - RPOH_METTH

Protein

DNA-directed RNA polymerase subunit H

Gene

rpoH

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-1050-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit HUniRule annotation (EC:2.7.7.6UniRule annotation)
    Alternative name(s):
    RPB5
    Gene namesi
    Name:rpoHUniRule annotation
    Ordered Locus Names:MTH_1048
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7777DNA-directed RNA polymerase subunit HPRO_0000146096Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH1048.

    Structurei

    Secondary structure

    1
    77
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 104
    Beta strandi13 – 175
    Helixi19 – 2810
    Turni33 – 353
    Helixi44 – 474
    Helixi48 – 503
    Beta strandi56 – 638
    Turni64 – 663
    Beta strandi67 – 748

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EIKNMR-A1-77[»]
    ProteinModelPortaliO27122.
    SMRiO27122. Positions 1-77.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO27122.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2012.
    KOiK03053.
    OMAiEHELVPK.

    Family and domain databases

    Gene3Di3.90.940.20. 1 hit.
    HAMAPiMF_00025. RNApol_RpoH_RPB5.
    InterProiIPR000783. RNA_pol_subH/Rpb5_C.
    IPR020608. RNA_pol_subH/Rpb5_CS.
    IPR020609. RpoH/RPB5.
    [Graphical view]
    PfamiPF01191. RNA_pol_Rpb5_C. 1 hit.
    [Graphical view]
    ProDomiPD005155. RNA_pol_subH/Rpb5_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF55287. SSF55287. 1 hit.
    PROSITEiPS01110. RNA_POL_H_23KD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O27122-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKREILKHQL VPEHVILNES EAKRVLKELD AHPEQLPKIK TTDPVAKAIG   50
    AKRGDIVKII RKSPTAEEFV TYRLVQD 77
    Length:77
    Mass (Da):8,808
    Last modified:January 1, 1998 - v1
    Checksum:i745435E11D2756DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85539.1.
    PIRiC69006.
    RefSeqiNP_276178.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB85539; AAB85539; MTH_1048.
    GeneIDi1471456.
    KEGGimth:MTH1048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85539.1 .
    PIRi C69006.
    RefSeqi NP_276178.1. NC_000916.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EIK NMR - A 1-77 [» ]
    ProteinModelPortali O27122.
    SMRi O27122. Positions 1-77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH1048.

    Protocols and materials databases

    DNASUi 1471456.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB85539 ; AAB85539 ; MTH_1048 .
    GeneIDi 1471456.
    KEGGi mth:MTH1048.

    Phylogenomic databases

    eggNOGi COG2012.
    KOi K03053.
    OMAi EHELVPK.

    Enzyme and pathway databases

    BioCyci MTHE187420:GJNM-1050-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O27122.

    Family and domain databases

    Gene3Di 3.90.940.20. 1 hit.
    HAMAPi MF_00025. RNApol_RpoH_RPB5.
    InterProi IPR000783. RNA_pol_subH/Rpb5_C.
    IPR020608. RNA_pol_subH/Rpb5_CS.
    IPR020609. RpoH/RPB5.
    [Graphical view ]
    Pfami PF01191. RNA_pol_Rpb5_C. 1 hit.
    [Graphical view ]
    ProDomi PD005155. RNA_pol_subH/Rpb5_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF55287. SSF55287. 1 hit.
    PROSITEi PS01110. RNA_POL_H_23KD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
    2. "Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum."
      Yee A., Booth V., Dharamsi A., Engel A., Edwards A.M., Arrowsmith C.H.
      Proc. Natl. Acad. Sci. U.S.A. 97:6311-6315(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiRPOH_METTH
    AccessioniPrimary (citable) accession number: O27122
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3