Reviewed, UniProtKB/Swiss-Prot O27112 (KORA_METTH)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate synthase subunit korA
    EC=1.2.7.3
Alternative name(s):
    2-ketoglutarate oxidoreductase alpha chain
      Short name=KOR
    2-oxoglutarate-ferredoxin oxidoreductase subunit alpha

Gene names

Name:	korA
Ordered Locus Names:	MTH_1033

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of the korA, korB, korC and korD subunits.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-oxoglutarate synthase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 376	375	2-oxoglutarate synthase subunit korA		PRO_0000099939

Sequences

	Sequence		Length	Mass (Da)
	O27112-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2C9E0C53399EAD1F	FASTA	376	41,377
	10 20 30 40 50 60 MTEEYFIQGN DACARGAIKA GCRFFAGYPI TPSTEIAEEM ALLLPREGGV FVQMEDEIGA 70 80 90 100 110 120 LGAVIGAVWS GVRGMTATSG PGFSLMQEHV GYAAMTETPL VIVNVQRGSP STGQPTMASQ 130 140 150 160 170 180 SDMMQARWGS HGDYEIIALS PSSVQECFDF TVRAFNLAEE YRVPVMVMGD EIVGHMREKI 190 200 210 220 230 240 TIPDRVKIRK RRGPSVPPEE FLPFSAPEDG VPEMPAFGDG YRIPVTGLTH DEGGYPDASN 250 260 270 280 290 300 PEGHHRLVKR LCDKILRHRD RISDVQEELT EDAYITVISY GAPSRSVATA VKMAREDGVR 310 320 330 340 350 360 AGYLKINTPW PFPETEVRAA AERSGKLLVV EMNLGQMFYE VQRVAAGMAE VELLPKIGGE 370 IHRPEEILNM ILKMNR

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000666 Genomic DNA. Translation: AAB85529.1. Different initiation.
PIR	H69004.
RefSeq	NP_276168.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1471441.
GenomeReviews	Gene locus MTH_1033 in contig AE000666_GR.
KEGG	mth:MTH1033.
NMPDR	fig|187420.1.peg.1023.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O27112.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH1033-MON.
BRENDA	1.2.7.3. 270.
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR015941. Transketolase_C-like. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF01855. POR_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KORA_METTH

Accession

Primary (citable) accession number: O27112

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	March 3, 2009
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)