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O27105 (PSD_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MTH_1026
OrganismMethanobacterium thermoautotrophicum (strain Delta H)
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000029831
Chain183 – 22341Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000029832

Sites

Site182 – 1832Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue1831Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
O27105 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 41E907A533DA1C04

FASTA22324,896
        10         20         30         40         50         60 
MLPKRASFLV SVATIPLLFG YHAIGILMFT VIAFMMQFFR DPDRIPPSDE DLIIAPADGR 

        70         80         90        100        110        120 
RLSGKIDRIE RVGSDYPLID RIFPDGSGGI LISTFMSPFD VHVNRAPVSG KVIYTEHVDG 

       130        140        150        160        170        180 
RFQVARSRVL TENEKNLIVI KTDYGNVGVI QIAGFVARRI VQYVKEGEYV ERGDRIGMIR 

       190        200        210        220 
FGSRVDLVLP ENCEVLVKTG SRPMAGETVV ARFNPGKKRV NVQ

« Hide

References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000666 Genomic DNA. Translation: AAB85522.1.
PIRH69003.
RefSeqNP_276161.1. NC_000916.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO27105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1471434.
GenomeReviewsGene locus MTH_1026 in contig AE000666_GR.
KEGGmth:MTH1026.
NMPDRfig|187420.1.peg.1016.

Phylogenomic databases

eggNOGarNOG08868.
HOGENOMHBG541103.
OMAIFMSVFN.
PhylomeDBO27105.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-15157.
MTHE187420:MTH1026-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_METTH
AccessionPrimary (citable) accession number: O27105
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 1, 1998
Last modified: December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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