O27041 (VATI_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase subunit I

Alternative name(s):
V-ATPase subunit I

Gene names

Name:	atpI
Ordered Locus Names:	MTH_960

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	658 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the V-ATPase 116 kDa subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting two-sector ATPase complex, proton-transporting domain Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 658	658	V-type ATP synthase subunit I		PRO_0000119231
Regions
	Transmembrane	383 – 403	21	Helical; Potential
	Transmembrane	427 – 447	21	Helical; Potential
	Transmembrane	475 – 495	21	Helical; Potential
	Transmembrane	507 – 526	20	Helical; Potential
	Transmembrane	530 – 552	23	Helical; Potential
	Transmembrane	568 – 588	21	Helical; Potential
	Transmembrane	591 – 611	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O27041 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 98E48D62EB43BE81	FASTA	658	74,476
	10 20 30 40 50 60 MSDMFLPARM RKLKIITLDQ YSDSVVRSLH EEGVTQIDDI SERIQQDAEW RQILKPSRAT 70 80 90 100 110 120 PYTGRVSSLL MKTSGILDFL GSVAAEEKGL RDTIREFINP PIFEKREVEE LDTESLIERA 130 140 150 160 170 180 EETLGRVESE TRVMEEKLNE LDSERSAVES SLSVAEKLKD FDIDFSDLQD SEYITGIAGR 190 200 210 220 230 240 ITAENLPELR DKLADITDEL VISDREGENK AERILIIVTL KKHADSIASV LRRMEFERFE 250 260 270 280 290 300 ISELQGRPSE IISSSKTRLE EISRERKEII SKLRDINAEW EDELLVLREQ LEIEKERNEV 310 320 330 340 350 360 FSLFGETRKT VMLEAWVPLK EADRVIAVVE ESSEGTALTD LEDPDPEEVP VLLDNPRFAK 370 380 390 400 410 420 PYETFVEMYS PLKYNEIDPT IFMAFVFPFF FGFCLTDAGY GIIDALIGFI LYRGLGKVNN 430 440 450 460 470 480 FMRNFGIIMM SCGVWAFILG MVTNGFIGDF FPRFFNITLP TVIPAIDAFV NPQNILIMAL 490 500 510 520 530 540 TVGVLHINFG LILGARNNIR LGNMREALGS QIVWLILELG IILYLVGGMI FGAPLIILAF 550 560 570 580 590 600 AMLLYYNGLF GLMDVSGFLG TLLSYARLLA LCLSTGGIAM TVNILTGLSY EMIPVIGVVL 610 620 630 640 650 APIIFVFGHI ANNAFQSLGA FINSLRLHYV EFFAQFYMGG KNKFNAFRAE RNFTKIRR

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85456.1.
PIR	E69228.
RefSeq	NP_276095.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O27041.
ModBase	Search...
Protein-protein interaction databases
IntAct	O27041. 2 interactions.
STRING	O27041.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1471368.
GenomeReviews	Gene locus MTH_960 in contig AE000666_GR.
KEGG	mth:MTH960.
NMPDR	fig|187420.1.peg.950.
Phylogenomic databases
eggNOG	arNOG04084.
HOGENOM	HBG539023.
OMA	FINLQDE.
ProtClustDB	PRK05771.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH960-MONOMER.
Family and domain databases
InterPro	IPR002490. ATPase_V0/A0-cplx_116kDa_su. [Graphical view]
KO	K02123.
Pfam	PF01496. V_ATPase_I. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATI_METTH

Accession

Primary (citable) accession number: O27041

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program