O27036 (VATA_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase alpha chain
EC=3.6.3.14

Alternative name(s):
V-ATPase subunit A

Gene names

Name:	atpA
Ordered Locus Names:	MTH_955

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	584 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. HAMAP MF_00309
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_00309
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	proton-transporting two-sector ATPase complex, catalytic domain Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 584	584	V-type ATP synthase alpha chain HAMAP MF_00309		PRO_0000144601
Regions
	Nucleotide binding	233 – 240	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O27036 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 90F01BD38B3D6D78	FASTA	584	64,895
	10 20 30 40 50 60 MTQEGRIIKI AGPVIIAEGM RGSQMYEMVK VGEDKLIGEI IELEGDTATI QVYEETAGIK 70 80 90 100 110 120 PGETVERTGG PLSVELGPGI LGSIFDGIQR PLENIKALTG DYIERGVDVP SLPKDKKWTF 130 140 150 160 170 180 KPTAREGQMV KGGDIIGEVE ETSSITHRIM IPPNVEGKLT MIAPQGEYTV LDDIAEVETE 190 200 210 220 230 240 SGTEKIQMLQ KWPVRKGRPY KKKLDPDVPL VTGQRAQDTF FSVAKGGTAA IPGPFGSGKT 250 260 270 280 290 300 VTQQQLAKWA DADIIVYVGC GERGNEMTEV LKEFPELEDP KTGNPLMDRT VLIANTSNMP 310 320 330 340 350 360 VAAREACVYT GITIAEYFRD MGYDVALMAD STSRWAEAMR EISGRLEEMP GEEGYPAYLA 370 380 390 400 410 420 SRLAQFYERA GRVTTIGSED KIASVSVVGA VSPPGGDLSE PVTQNTLRIC KVFWALDASL 430 440 450 460 470 480 ADKRHFPSID WLQSYSLYID SVQEWWASNV DPEWRKFRDE AMALLQKEAE LQEIVQLVGP 490 500 510 520 530 540 DALPDRERIT LETTRMIRED FLQQNAYHEV DTYCSPSKQF EMLRTIIMFH RNATAALEKG 550 560 570 580 APAADIISLP VKEDIGRMKY IPEEEFPARI KEIQERIVKE CSEV

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85451.1.
PIR	G69227.
RefSeq	NP_276090.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O27036.
SMR	O27036. Positions 60-560.
ModBase	Search...
Protein-protein interaction databases
IntAct	O27036. 3 interactions.
STRING	O27036.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1471363.
GenomeReviews	Gene locus MTH_955 in contig AE000666_GR.
KEGG	mth:MTH955.
NMPDR	fig|187420.1.peg.945.
Phylogenomic databases
eggNOG	arNOG04086.
HOGENOM	HBG288114.
OMA	SENKITW.
ProtClustDB	PRK04192.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH955-MONOMER.
Family and domain databases
HAMAP	MF_00309. ATP_synth_A_arch. [Tree]
InterPro	IPR020003. ATPase_a/bsu_AS. IPR005726. ATPase_A1-cplx_asu. IPR018118. ATPase_F1/A1-cplx_a/bsu_N. IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR024034. ATPase_F1_bsu/V1_C. IPR022878. V-ATPase_su_A/alpha. [Graphical view]
Gene3D	G3DSA:1.10.1140.10. G3DSA:1.10.1140.10. 1 hit. G3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KO	K02117.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SUPFAM	SSF47917. ATPase_a/b_C. 1 hit. SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMs	TIGR01043. ATP_syn_A_arch. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATA_METTH

Accession

Primary (citable) accession number: O27036

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program