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Protein

Fructose-1,6-bisphosphatase/inositol-1-monophosphatase

Gene

suhB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, and both D and L isomers of inositol-1-phosphate (I-1-P).By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.By similarity
Myo-inositol phosphate + H2O = myo-inositol + phosphate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Magnesium 1By similarity
Metal bindingi94 – 941Magnesium 1By similarity
Metal bindingi94 – 941Magnesium 2By similarity
Metal bindingi96 – 961Magnesium 1; via carbonyl oxygenBy similarity
Metal bindingi97 – 971Magnesium 2By similarity
Binding sitei195 – 1951SubstrateBy similarity
Binding sitei200 – 2001Substrate; via amide nitrogenBy similarity
Binding sitei219 – 2191SubstrateBy similarity
Metal bindingi226 – 2261Magnesium 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Gluconeogenesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-873-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (EC:3.1.3.11By similarity, EC:3.1.3.25By similarity)
Short name:
FBPase/IMPase
Alternative name(s):
Inositol-1-phosphatase
Short name:
I-1-Pase
Gene namesi
Name:suhB
Ordered Locus Names:MTH_871
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Fructose-1,6-bisphosphatase/inositol-1-monophosphatasePRO_0000142581Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH871.

Structurei

3D structure databases

ProteinModelPortaliO26957.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 993Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiarCOG01349. Archaea.
COG0483. LUCA.
KOiK01092.
OMAiSALELCY.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESDIYYWK GVAVRMAEQV ERAVSPLVGT EDAGEIIKMG ADGTPTKLID
60 70 80 90 100
LVAEDEAVGV LESTGRPVTI ISEEIGVLHI NSEGDEPGII FVVDPLDGTS
110 120 130 140 150
NAIRNIPFYG ISVAVAERHP DGAAPTLNNV LMGFVKNFAT GDLYWAIKGQ
160 170 180 190 200
GAFLNEKAIS SSSQSSLDRT SLGAFIYGTR FRRVDSICRV IRRMRILGSV
210 220 230 240 250
ALELAYVASG SYDAFMDLRE NLRIVDIAAS KLIVEEAGGV VTNERGGEID
260 270 280
GLLNVKARTS LVAAGNLELH EKIMQTLEVI
Length:280
Mass (Da):30,173
Last modified:January 1, 1998 - v1
Checksum:iF0AE435970AED882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85369.1.
PIRiD69216.
RefSeqiWP_010876504.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85369; AAB85369; MTH_871.
GeneIDi1471279.
KEGGimth:MTH_871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85369.1.
PIRiD69216.
RefSeqiWP_010876504.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO26957.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85369; AAB85369; MTH_871.
GeneIDi1471279.
KEGGimth:MTH_871.

Phylogenomic databases

eggNOGiarCOG01349. Archaea.
COG0483. LUCA.
KOiK01092.
OMAiSALELCY.

Enzyme and pathway databases

UniPathwayiUPA00138.
BioCyciMTHE187420:GJNM-873-MONOMER.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiBSUHB_METTH
AccessioniPrimary (citable) accession number: O26957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.