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Protein

Fructose-1,6-bisphosphatase/inositol-1-monophosphatase

Gene

suhB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, and both D and L isomers of inositol-1-phosphate (I-1-P).By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.By similarity
Myo-inositol phosphate + H2O = myo-inositol + phosphate.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi73Magnesium 1By similarity1
Metal bindingi94Magnesium 1By similarity1
Metal bindingi94Magnesium 2By similarity1
Metal bindingi96Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi97Magnesium 2By similarity1
Binding sitei195SubstrateBy similarity1
Binding sitei200Substrate; via amide nitrogenBy similarity1
Binding sitei219SubstrateBy similarity1
Metal bindingi226Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-835-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (EC:3.1.3.11By similarity, EC:3.1.3.25By similarity)
Short name:
FBPase/IMPase
Alternative name(s):
Inositol-1-phosphatase
Short name:
I-1-Pase
Gene namesi
Name:suhB
Ordered Locus Names:MTH_871
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425811 – 280Fructose-1,6-bisphosphatase/inositol-1-monophosphataseAdd BLAST280

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH871

Structurei

3D structure databases

ProteinModelPortaliO26957
SMRiO26957
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 99Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01349 Archaea
COG0483 LUCA
KOiK01092
OMAiSALELCY
OrthoDBiPOG093Z07HH

Family and domain databases

InterProiView protein in InterPro
IPR020583 Inositol_monoP_metal-BS
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PRINTSiPR00377 IMPHPHTASES
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

O26957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESDIYYWK GVAVRMAEQV ERAVSPLVGT EDAGEIIKMG ADGTPTKLID
60 70 80 90 100
LVAEDEAVGV LESTGRPVTI ISEEIGVLHI NSEGDEPGII FVVDPLDGTS
110 120 130 140 150
NAIRNIPFYG ISVAVAERHP DGAAPTLNNV LMGFVKNFAT GDLYWAIKGQ
160 170 180 190 200
GAFLNEKAIS SSSQSSLDRT SLGAFIYGTR FRRVDSICRV IRRMRILGSV
210 220 230 240 250
ALELAYVASG SYDAFMDLRE NLRIVDIAAS KLIVEEAGGV VTNERGGEID
260 270 280
GLLNVKARTS LVAAGNLELH EKIMQTLEVI
Length:280
Mass (Da):30,173
Last modified:January 1, 1998 - v1
Checksum:iF0AE435970AED882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85369.1
PIRiD69216
RefSeqiWP_010876504.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85369; AAB85369; MTH_871
GeneIDi1471279
KEGGimth:MTH_871
PATRICifig|187420.15.peg.855

Similar proteinsi

Entry informationi

Entry nameiBSUHB_METTH
AccessioniPrimary (citable) accession number: O26957
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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