Reviewed, UniProtKB/Swiss-Prot O26957 (SUHB_METTH)

Names and origin

Protein names

Recommended name:
    Inositol-1-monophosphatase
      Short name=IMPase
      Short name=Inositol-1-phosphatase
      Short name=I-1-Pase
    EC=3.1.3.25

Gene names

Name:	suhB
Ordered Locus Names:	MTH_871

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Inositol-1-monophosphatase		PRO_0000142581
Sites
	Metal binding	73	1	Magnesium 1 By similarity
	Metal binding	94	1	Magnesium 1 By similarity
	Metal binding	94	1	Magnesium 2 By similarity
	Metal binding	96	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	97	1	Magnesium 2 By similarity
	Metal binding	226	1	Magnesium 2 By similarity
	Binding site	97	1	Substrate By similarity
	Binding site	219	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O26957-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: F0AE435970AED882	FASTA	280	30,173
	10 20 30 40 50 60 MEESDIYYWK GVAVRMAEQV ERAVSPLVGT EDAGEIIKMG ADGTPTKLID LVAEDEAVGV 70 80 90 100 110 120 LESTGRPVTI ISEEIGVLHI NSEGDEPGII FVVDPLDGTS NAIRNIPFYG ISVAVAERHP 130 140 150 160 170 180 DGAAPTLNNV LMGFVKNFAT GDLYWAIKGQ GAFLNEKAIS SSSQSSLDRT SLGAFIYGTR 190 200 210 220 230 240 FRRVDSICRV IRRMRILGSV ALELAYVASG SYDAFMDLRE NLRIVDIAAS KLIVEEAGGV 250 260 270 280 VTNERGGEID GLLNVKARTS LVAAGNLELH EKIMQTLEVI

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000666 Genomic DNA. Translation: AAB85369.1.
PIR	D69216.
RefSeq	NP_276008.1.
3D structure databases
HSSP	HSSP built from PDB template 1LBV based on UniProtKB O30298.
ModBase	Search...
Protein-protein interaction databases
STRING	O26957.
Genome annotation databases
GeneID	1471279.
GenomeReviews	Gene locus MTH_871 in contig AE000666_GR.
KEGG	mth:MTH871.
NMPDR	fig|187420.1.peg.863.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O26957.
OMA	VALELCY.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH871-MON.
BRENDA	3.1.3.25. 270.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00377. IMPHPHTASES.
ProDom	PD001491. In_FB_phphtase. 2 hits. PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUHB_METTH

Accession

Primary (citable) accession number: O26957

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)