O26956 (PDAD_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvoyl-dependent arginine decarboxylase
Short name=PvlArgDC
EC=4.1.1.19

Cleaved into the following 2 chains:

1. Pyruvoyl-dependent arginine decarboxylase subunit beta
2. Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	pdaD
Ordered Locus Names:	MTH_870

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity. HAMAP MF_01404
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 41	41	Pyruvoyl-dependent arginine decarboxylase subunit beta By similarity		PRO_0000023324
	Chain	42 – 151	110	Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarity		PRO_0000023325
Sites
	Site	41 – 42	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	42	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O26956 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 823DD6E28A32E36D	FASTA	151	16,114
	10 20 30 40 50 60 MVIVMKVAIT SGAAEGPTKL NAFDNALLQA GIGDVNLIKV SSILPRNTRI VELPELEPGS 70 80 90 100 110 120 IVNCVLSHMV SERRGDLISA AVAVATSSDF GCVVENSSVN RDPEDVRSEA ISMVRYMMSV 130 140 150 RGLEIKELIV EETNHVVEKC GAAVSAVVYL D

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85368.1.
PIR	C69216.
RefSeq	NP_276007.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26956.
SMR	O26956. Positions 7-41.
ModBase	Search...
Protein-protein interaction databases
STRING	O26956.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1471278.
GenomeReviews	Gene locus MTH_870 in contig AE000666_GR.
KEGG	mth:MTH870.
NMPDR	fig|187420.1.peg.862.
Phylogenomic databases
eggNOG	arNOG09108.
HOGENOM	HBG539680.
OMA	MVNCVLS.
ProtClustDB	CLSK798021.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH870-MONOMER.
Family and domain databases
HAMAP	MF_01404. PvlArgDC. [Tree]
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
KO	K02626.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56271. His_carbxylase. 1 hit.
TIGRFAMs	TIGR00286. TIGR00286. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD_METTH

Accession

Primary (citable) accession number: O26956

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program