O26893 (O26893_METTH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aspartokinase RuleBase RU003448
EC=2.7.2.4 RuleBase RU003448

Gene names

Ordered Locus Names:

MTH_802 EMBL AAB85302.1

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate. RuleBase RU003448
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 1/4. RuleBase RU004249 Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. RuleBase RU004249 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. RuleBase RU004249
Sequence similarities	Belongs to the aspartokinase family. RuleBase RU003448

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004249
Molecular function	Kinase RuleBase RU003448 EMBL AAB85302.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O26893 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0240A851AEF34D2F	FASTA	406	44,043
	10 20 30 40 50 60 MELIVAKFGG TSIGNGRRIK KAARSVVKEY MKGRKVVVVV SAINKTTDEL LQIVDEAMED 70 80 90 100 110 120 AVTEKQLAEI VSMGEMTSVR IFSSAIEALG VKSEYIDPFM DEWPIITDSN LLNAKVDFEA 130 140 150 160 170 180 TEEKSRELLK LLDQGIIPVV CGFLGRDPNG YITTLGRGGS DITAFLLGHC LKADEVIIVT 190 200 210 220 230 240 DVGGVMSTDP NKLQGAKKLD KISVEEMRDL ATHGAQVLHP HALKYKDPDI KAKIIGFEHG 250 260 270 280 290 300 DLSAPGTEII GPSKNKMVKT TTLNPDPISV VAVVGEKILN KPGILARLTS RLAENSINII 310 320 330 340 350 360 GISTGQNSVT IFVDKKDADE AHRLLHDVVI ADDDLSSLSL GRDIAMITIS SPDFIDTPGI 370 380 390 400 ISEITKPLRD NDLNIVEISS SQTSVVIFVD WNDGKKAYEL VRGVLE

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85302.1.
PIR	B69207.
RefSeq	NP_275941.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26893.
ModBase	Search...
Protein-protein interaction databases
STRING	O26893.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1471210.
GenomeReviews	Gene locus MTH_802 in contig AE000666_GR.
KEGG	mth:MTH802.
NMPDR	fig|187420.1.peg.796.
Phylogenomic databases
eggNOG	arNOG05088.
HOGENOM	HBG724395.
OMA	QGSSETN.
PhylomeDB	O26893.
ProtClustDB	PRK06635.
Family and domain databases
InterPro	IPR002912. ACT-bd. IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00928.
Pfam	PF00696. AA_kinase. 1 hit. PF01842. ACT. 2 hits. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00656. Asp_kin_monofn. 1 hit. TIGR00657. Asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O26893_METTH

Accession

Primary (citable) accession number: O26893

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)