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Protein

Archaeal Lon protease

Gene

MTH_785

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei524 – 5241By similarity
Active sitei567 – 5671By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-787-MONOMER.

Protein family/group databases

MEROPSiS16.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Archaeal Lon protease (EC:3.4.21.-)
Alternative name(s):
ATP-dependent protease La homolog
Gene namesi
Ordered Locus Names:MTH_785
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 137137CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15518HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17116HelicalSequence analysisAdd
BLAST
Topological domaini172 – 644473CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Archaeal Lon proteasePRO_0000076153Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity (By similarity).By similarity

Protein-protein interaction databases

STRINGi187420.MTH785.

Structurei

3D structure databases

ProteinModelPortaliO26878.
SMRiO26878. Positions 431-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini438 – 617180Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG02160. Archaea.
COG1067. LUCA.
KOiK04076.
OMAiDVHIQFV.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004663. Lon_arc.
IPR027065. Lon_Prtase.
IPR000523. Mg_chelatse_chII_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 2 hits.
PfamiPF05362. Lon_C. 1 hit.
PF01078. Mg_chelatase. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00764. lon_rel. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTIKNSRT QESVSYEGNE TKKGTGETLS YETSKDIEVP ERLIDQIIGQ
60 70 80 90 100
EEAVETIKKA AEQRRNVLLI GEPGVGKSML AKAMAELLPR EQLQDILVYP
110 120 130 140 150
NIEDPNNPLI GAVPAGEGRK IVMNHKNKAR SQDEKKNLFM MLIISFILVL
160 170 180 190 200
GFMMNQFLAA IIAAGIIFLA LQQFRPRTTV MVPKLLVNNE GRQVAPFVDA
210 220 230 240 250
TGAHAGALLG DVRHDPYQSG GLGTPAHERV EAGMIHKANK GVLYIDEIGT
260 270 280 290 300
MKMKTQQELL TAMQEKRYSI TGQSETSSGA MVRSQAVPCD FVLVASGNLQ
310 320 330 340 350
VLEGMHPALR SRIRGYGYEV FMKDTMPDTP ENRDKLVQFV AQEVEKDGRI
360 370 380 390 400
PHFSREAVEE IIREAQRRAG KKDSLTLKLR ELGGLVRAAG DIAKSRGAEL
410 420 430 440 450
VETEDVIEAK KLSRTLEQQI ADRYIVQKKK YSVFKSEGGE VGRVNGLAII
460 470 480 490 500
GDRSGIILPI AAEAAPAQSK EEGRIIATGK LGEIAREAVQ NVSALIKKYT
510 520 530 540 550
GTDISNYDIH IQFLQAYDGV EGDSASVSVA TAVISALEEI PVDQSVALTG
560 570 580 590 600
SLSIRGDVLP VGGVTGKIEA AAEAGIRKVL IPASNMGDVM IEKKYEDMVE
610 620 630 640
IVPVETLGDV LEHALIGKGK ESLIQRMQKI SDIVPSIMKK PAMH
Length:644
Mass (Da):70,212
Last modified:January 1, 1998 - v1
Checksum:iA04A3C18412C3BD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85287.1.
PIRiH69204.
RefSeqiWP_010876422.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85287; AAB85287; MTH_785.
GeneIDi1471193.
KEGGimth:MTH785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85287.1.
PIRiH69204.
RefSeqiWP_010876422.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO26878.
SMRiO26878. Positions 431-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH785.

Protein family/group databases

MEROPSiS16.005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85287; AAB85287; MTH_785.
GeneIDi1471193.
KEGGimth:MTH785.

Phylogenomic databases

eggNOGiarCOG02160. Archaea.
COG1067. LUCA.
KOiK04076.
OMAiDVHIQFV.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-787-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004663. Lon_arc.
IPR027065. Lon_Prtase.
IPR000523. Mg_chelatse_chII_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 2 hits.
PfamiPF05362. Lon_C. 1 hit.
PF01078. Mg_chelatase. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00764. lon_rel. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiLONB_METTH
AccessioniPrimary (citable) accession number: O26878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: February 17, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.