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O26867 (MCH_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methenyltetrahydromethanopterin cyclohydrolase
EC=3.5.4.27
Alternative name(s):
Methenyl-H4MPT cyclohydrolase
Gene names
Name:mch
Ordered Locus Names:MTH_773
OrganismMethanobacterium thermoautotrophicum (strain Delta H)
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of 5-formyl-H4MPT to methenyl-H4MPT+ By similarity. HAMAP MF_00486

Catalytic activity

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin. HAMAP MF_00486

Pathway

One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3. HAMAP MF_00486

Subcellular location

Cytoplasm By similarity HAMAP MF_00486.

Sequence similarities

Belongs to the MCH family.

Ontologies

Keywords
   Biological processMethanogenesis
One-carbon metabolism
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmethanogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

one-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmethenyltetrahydromethanopterin cyclohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Methenyltetrahydromethanopterin cyclohydrolase HAMAP MF_00486
PRO_0000140884

Sequences

Sequence LengthMass (Da)Tools
O26867 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C10CE738C675AA02

FASTA32034,319
        10         20         30         40         50         60 
MVSVNLEAKK IVDRMIEKAD DLKIKVDKLE NGSTVIDCGV NVDGSIKAGE LYTGVCLGGL 

        70         80         90        100        110        120 
ADVGISIPGD LSERFALPSV KIKTDFPAIS TLGAQKAGWS VSVGDFFALG SGPARALSLK 

       130        140        150        160        170        180 
PAETYEEIGY QDEADVAILT LEADKLPGED VTDMIAEECD VAAENVYVLV APTSSLVGSI 

       190        200        210        220        230        240 
QISGRVVENG TYKMLEALHF DVNKVKYAAG IAPIAPVDPD SLKAMGKTND AVLFGGRTYY 

       250        260        270        280        290        300 
YIESEEGDDI KSLAENLPSS ASEGYGKPFY DVFREADYDF YKIDKGMFAP AEVVINDLRT 

       310        320 
GDVFRAGFVN EELLMKSFGL

« Hide

References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000666 Genomic DNA. Translation: AAB85276.1.
PIRD69203.
RefSeqNP_275915.1. NC_000916.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IOZmodel-A1-320[»]
ProteinModelPortalO26867.
SMRO26867. Positions 1-320.
ModBaseSearch...

Protein-protein interaction databases

STRINGO26867.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1471181.
GenomeReviewsGene locus MTH_773 in contig AE000666_GR.
KEGGmth:MTH773.
NMPDRfig|187420.1.peg.770.

Phylogenomic databases

eggNOGarNOG05033.
HOGENOMHBG497176.
OMAYFAMGSG.
ProtClustDBPRK02264.

Enzyme and pathway databases

BioCycMTHE187420:MTH773-MONOMER.

Family and domain databases

HAMAPMF_00486. McH.
[Tree]
InterProIPR003209. METHMP_CycHdrlase.
[Graphical view]
KOK01499.
PfamPF02289. MCH. 1 hit.
[Graphical view]
SUPFAMSSF56199. Cyclohydrolase. 1 hit.
TIGRFAMsTIGR03120. One_C_mch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMCH_METTH
AccessionPrimary (citable) accession number: O26867
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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