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O26843 (AROC_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:MTH_748
OrganismMethanobacterium thermoautotrophicum (strain Delta H)
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Chorismate synthase HAMAP MF_00300
PRO_0000140693

Sequences

Sequence LengthMass (Da)Tools
O26843 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1C30409D90C44D42

FASTA37439,589
        10         20         30         40         50         60 
MILCGDSVAG NSTGEMFRVT TFGSSHGPAV GAVIDGCPAG LELSEDDIQQ ELNRRRPGTG 

        70         80         90        100        110        120 
ALTTPRAESD RVEILSGIFR GRTDGTPIAG IVRNLDADSK SYSNIKNTPR PGHGDYTWRA 

       130        140        150        160        170        180 
RFRNYDYRGG GRGSGRVTIG HVIGGAVAKK LIGNYGLTVT GHVVQVGDVK ADTVSLKRIG 

       190        200        210        220        230        240 
EYAESNPVRC ADPRAARQME KVILDARSRG DSVGGVVEVV VLGAPPGLGD PVFSKLDADM 

       250        260        270        280        290        300 
ARALMGIGSV KGVEIGMGFE VAEHRASEIN DEFYLDDDGK VRTTTNTSGG ILGGISSGMP 

       310        320        330        340        350        360 
ITARIAVKPT PSISVPQKTV DLERMEETTI EVRGRHDPCI CPRVVPVAEA AVAIVLADHM 

       370 
IRAGFIHPTY IGNE

« Hide

References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000666 Genomic DNA. Translation: AAB85252.1.
PIRA69200.
RefSeqNP_275891.1. NC_000916.1.

3D structure databases

ProteinModelPortalO26843.
ModBaseSearch...

Protein-protein interaction databases

STRINGO26843.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1471156.
GenomeReviewsGene locus MTH_748 in contig AE000666_GR.
KEGGmth:MTH748.
NMPDRfig|187420.1.peg.746.

Phylogenomic databases

eggNOGarNOG04618.
HOGENOMHBG292336.
OMASRFTTQR.
PhylomeDBO26843.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycMTHE187420:MTH748-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_METTH
AccessionPrimary (citable) accession number: O26843
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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