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O26839

- HEM2_METTH

UniProt

O26839 - HEM2_METTH

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Protein
Delta-aminolevulinic acid dehydratase
Gene
hemB, MTH_744
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactori

Binds 1 zinc ion per monomer By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi125 – 1251Zinc; catalytic By similarity
Metal bindingi127 – 1271Zinc; catalytic By similarity
Metal bindingi135 – 1351Zinc; catalytic By similarity
Active sitei200 – 2001Schiff-base intermediate with substrate By similarity
Binding sitei210 – 2101Substrate 1 By similarity
Binding sitei222 – 2221Substrate 1 By similarity
Metal bindingi238 – 2381Magnesium By similarity
Active sitei253 – 2531Schiff-base intermediate with substrate By similarity
Binding sitei279 – 2791Substrate 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-746-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:MTH_744
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Delta-aminolevulinic acid dehydratase
PRO_0000140525Add
BLAST

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

STRINGi187420.MTH744.

Structurei

3D structure databases

ProteinModelPortaliO26839.
SMRiO26839. Positions 10-324.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.

Phylogenomic databases

eggNOGiCOG0113.
KOiK01698.
OMAiDMILTYF.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26839-1 [UniParc]FASTAAdd to Basket

« Hide

MSDNMEFPTK RMRRLRKSPQ IRNILRETRL HPSDLIYPMF VSEKLGRGDV    50
EAIDTMPGQF RYSVDDAVSE ASRLEDEGLS SVLIFGMPSA KDELASAAHD 100
PHGVVQRTVR RLKEETDLVV MTDVCLCQYT SHGHCGIVVD GEIVNDETLE 150
VLSRIALSHA EAGADVVAPS DMMDGRVAAI RRSLDDAGFQ DTLIMSYAVK 200
YASAFYAPFR GAVSSAPAFG DRRSYQMDPA NIDEALIEAE LDLREGADIL 250
MVKPALAYLD VIGKVRERFS VPLAAYNVSG EYSMLKAAIK SGYLTDEAIY 300
ESILSIKRAG ADLIISHFAP DLLGVI 326
Length:326
Mass (Da):35,841
Last modified:January 1, 1998 - v1
Checksum:i29EDC9060F39A170
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB85248.1.
PIRiE69199.
RefSeqiNP_275887.1. NC_000916.1.
WP_010876383.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85248; AAB85248; MTH_744.
GeneIDi1471152.
KEGGimth:MTH744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB85248.1 .
PIRi E69199.
RefSeqi NP_275887.1. NC_000916.1.
WP_010876383.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26839.
SMRi O26839. Positions 10-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB85248 ; AAB85248 ; MTH_744 .
GeneIDi 1471152.
KEGGi mth:MTH744.

Phylogenomic databases

eggNOGi COG0113.
KOi K01698.
OMAi DMILTYF.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci MTHE187420:GJNM-746-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiHEM2_METTH
AccessioniPrimary (citable) accession number: O26839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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