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Protein

Putative phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

MTH_735

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Ordered Locus Names:MTH_735
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei44 – 64HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 178HelicalUniRule annotationAdd BLAST21
Transmembranei181 – 201HelicalUniRule annotationAdd BLAST21
Transmembranei212 – 232HelicalUniRule annotationAdd BLAST21
Transmembranei235 – 255HelicalUniRule annotationAdd BLAST21
Transmembranei258 – 278HelicalUniRule annotationAdd BLAST21
Transmembranei281 – 301HelicalUniRule annotationAdd BLAST21
Transmembranei328 – 348HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001089371 – 351Putative phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST351

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH735.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG03199. Archaea.
COG0472. LUCA.
KOiK01000.
OMAiISLMHRA.
OrthoDBiPOG093Z088R.

Family and domain databases

HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O26830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEFLMVFII STVSAAVFTL FIRNILRSAD IGDKPIVTEH SHKAGTPTMG
60 70 80 90 100
GLGMLLALLL VTVLYRNNPY LVLTSLIVLT AAIVGLLDDL LGLKVKEVQR
110 120 130 140 150
IIRNVSEGPL EVGQLVLKPG EEARAATDKA KRDVEALLSE GLVEVVGEAP
160 170 180 190 200
IKNEVSEGEK ILAQLLIGVF LVLSGAVGKL GGFYLGLAAA PIAIAGMVGA
210 220 230 240 250
INAVNLIDGM DGMAAGIMLI ASLSCAIFLG LSGQALPFLA LAGMCAGFLV
260 270 280 290 300
FNRHPASIFM GDTGSFALGA GYATAVMLTD TVYFGVLAIA VPVVSVIVSL
310 320 330 340 350
LHRAGVIRLP VEPLHHTLHY RGMSERRIVL LYWLITLIVC ALGLYMTGSI

L
Length:351
Mass (Da):37,003
Last modified:January 1, 1998 - v1
Checksum:i54A9058D3148574E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85239.1.
PIRiC69198.
RefSeqiWP_010876374.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85239; AAB85239; MTH_735.
GeneIDi1470695.
KEGGimth:MTH_735.
PATRICifig|187420.15.peg.722.

Similar proteinsi

Entry informationi

Entry nameiMRAY_METTH
AccessioniPrimary (citable) accession number: O26830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families