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O26819

- CIMA_METTH

UniProt

O26819 - CIMA_METTH

Protein

Putative (R)-citramalate synthase CimA

Gene

cimA

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. (R)-citramalate synthase activity Source: InterPro
    2. 2-isopropylmalate synthase activity Source: InterPro
    3. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. leucine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-725-MONOMER.
    UniPathwayiUPA00047; UER00066.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative (R)-citramalate synthase CimAUniRule annotation (EC:2.3.1.182UniRule annotation)
    Gene namesi
    Name:cimAUniRule annotation
    Ordered Locus Names:MTH_723
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Putative (R)-citramalate synthase CimAPRO_0000140453Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi187420.MTH723.

    Structurei

    3D structure databases

    ProteinModelPortaliO26819.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-IPM synthase/homocitrate synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0119.
    KOiK09011.
    OMAiERICACD.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01028. CimA.
    InterProiIPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR024890. Citramalate_synthase_CimA.
    IPR011830. LEU1_arch.
    IPR000891. PYR_CT.
    [Graphical view]
    PfamiPF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view]
    SMARTiSM00917. LeuA_dimer. 1 hit.
    [Graphical view]
    SUPFAMiSSF110921. SSF110921. 1 hit.
    TIGRFAMsiTIGR02090. LEU1_arch. 1 hit.
    PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O26819-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVRVLDTTL RDGEQTPGVS LTPEEKLRIA LKIDALGADI IEAGSAITSE    50
    GEREGIRKIT SEGLRAEICS FARAVREDID AAISCDVDSV HLVVPTSDLH 100
    LEHKLRKTRE EVLEQAVDCT EYAVDHGILV ELSAEDSTRS DMDFLRTIFR 150
    EGIEAGAERI CACDTVGILT PERSYEFYRG LSELGAPLSV HCHNDFGLAV 200
    ANSLAGLRAG ASEVHATING IGERAGNAAL EEVVVALKSL YDVDTSINIE 250
    MLYETSRMVA RMTGVYLQPN KAIVGENAFA HESGIHADGV LKKAETYEPI 300
    TPEMVGHGRG FVMGKHIGTH ALRKRLDELG MKVADDKLME IFRRVKTLGD 350
    MGKCVTDVDL QAIAEDVLGV MEDKVVDLQE VTIVSGNRVT PTASVKLRVD 400
    DREVLEAGTG VGPVDAAIVA IKKSLEDFAD ITLEEYHVDA ITGGTDALID 450
    VVIKLRHGDR IISARSTQPD IIMASVEAFL SGVNRLLANE KSEGTH 496
    Length:496
    Mass (Da):53,705
    Last modified:January 1, 1998 - v1
    Checksum:iFCB4D5CDC2F5A115
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85228.1.
    PIRiF69196.
    RefSeqiNP_275866.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB85228; AAB85228; MTH_723.
    GeneIDi1470684.
    KEGGimth:MTH723.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB85228.1 .
    PIRi F69196.
    RefSeqi NP_275866.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O26819.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH723.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB85228 ; AAB85228 ; MTH_723 .
    GeneIDi 1470684.
    KEGGi mth:MTH723.

    Phylogenomic databases

    eggNOGi COG0119.
    KOi K09011.
    OMAi ERICACD.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00066 .
    BioCyci MTHE187420:GJNM-725-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01028. CimA.
    InterProi IPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR024890. Citramalate_synthase_CimA.
    IPR011830. LEU1_arch.
    IPR000891. PYR_CT.
    [Graphical view ]
    Pfami PF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view ]
    SMARTi SM00917. LeuA_dimer. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110921. SSF110921. 1 hit.
    TIGRFAMsi TIGR02090. LEU1_arch. 1 hit.
    PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiCIMA_METTH
    AccessioniPrimary (citable) accession number: O26819
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3