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O26819

- CIMA_METTH

UniProt

O26819 - CIMA_METTH

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Protein

Putative (R)-citramalate synthase CimA

Gene

cimA

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.UniRule annotation

Catalytic activityi

Acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. (R)-citramalate synthase activity Source: InterPro
  2. 2-isopropylmalate synthase activity Source: InterPro
  3. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. leucine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-725-MONOMER.
UniPathwayiUPA00047; UER00066.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative (R)-citramalate synthase CimAUniRule annotation (EC:2.3.1.182UniRule annotation)
Gene namesi
Name:cimAUniRule annotation
Ordered Locus Names:MTH_723
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Putative (R)-citramalate synthase CimAPRO_0000140453Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi187420.MTH723.

Structurei

3D structure databases

ProteinModelPortaliO26819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-IPM synthase/homocitrate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0119.
KOiK09011.
OMAiERICACD.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01028. CimA.
InterProiIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR024890. Citramalate_synthase_CimA.
IPR011830. LEU1_arch.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTiSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF110921. SSF110921. 1 hit.
TIGRFAMsiTIGR02090. LEU1_arch. 1 hit.
PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26819-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVRVLDTTL RDGEQTPGVS LTPEEKLRIA LKIDALGADI IEAGSAITSE
60 70 80 90 100
GEREGIRKIT SEGLRAEICS FARAVREDID AAISCDVDSV HLVVPTSDLH
110 120 130 140 150
LEHKLRKTRE EVLEQAVDCT EYAVDHGILV ELSAEDSTRS DMDFLRTIFR
160 170 180 190 200
EGIEAGAERI CACDTVGILT PERSYEFYRG LSELGAPLSV HCHNDFGLAV
210 220 230 240 250
ANSLAGLRAG ASEVHATING IGERAGNAAL EEVVVALKSL YDVDTSINIE
260 270 280 290 300
MLYETSRMVA RMTGVYLQPN KAIVGENAFA HESGIHADGV LKKAETYEPI
310 320 330 340 350
TPEMVGHGRG FVMGKHIGTH ALRKRLDELG MKVADDKLME IFRRVKTLGD
360 370 380 390 400
MGKCVTDVDL QAIAEDVLGV MEDKVVDLQE VTIVSGNRVT PTASVKLRVD
410 420 430 440 450
DREVLEAGTG VGPVDAAIVA IKKSLEDFAD ITLEEYHVDA ITGGTDALID
460 470 480 490
VVIKLRHGDR IISARSTQPD IIMASVEAFL SGVNRLLANE KSEGTH
Length:496
Mass (Da):53,705
Last modified:January 1, 1998 - v1
Checksum:iFCB4D5CDC2F5A115
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB85228.1.
PIRiF69196.
RefSeqiNP_275866.1. NC_000916.1.
WP_010876362.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85228; AAB85228; MTH_723.
GeneIDi1470684.
KEGGimth:MTH723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB85228.1 .
PIRi F69196.
RefSeqi NP_275866.1. NC_000916.1.
WP_010876362.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26819.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH723.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB85228 ; AAB85228 ; MTH_723 .
GeneIDi 1470684.
KEGGi mth:MTH723.

Phylogenomic databases

eggNOGi COG0119.
KOi K09011.
OMAi ERICACD.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00066 .
BioCyci MTHE187420:GJNM-725-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01028. CimA.
InterProi IPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR024890. Citramalate_synthase_CimA.
IPR011830. LEU1_arch.
IPR000891. PYR_CT.
[Graphical view ]
Pfami PF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view ]
SMARTi SM00917. LeuA_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF110921. SSF110921. 1 hit.
TIGRFAMsi TIGR02090. LEU1_arch. 1 hit.
PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiCIMA_METTH
AccessioniPrimary (citable) accession number: O26819
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3