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Protein

Putative (R)-citramalate synthase CimA

Gene

cimA

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.UniRule annotation

Catalytic activityi

Acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate.UniRule annotation

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 2-oxobutanoate from pyruvate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Putative (R)-citramalate synthase CimA (cimA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-oxobutanoate from pyruvate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-688-MONOMER
UniPathwayiUPA00047; UER00066

Names & Taxonomyi

Protein namesi
Recommended name:
Putative (R)-citramalate synthase CimAUniRule annotation (EC:2.3.1.182UniRule annotation)
Gene namesi
Name:cimAUniRule annotation
Ordered Locus Names:MTH_723
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001404531 – 496Putative (R)-citramalate synthase CimAAdd BLAST496

Proteomic databases

PRIDEiO26819

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi187420.MTH723

Structurei

3D structure databases

ProteinModelPortaliO26819
SMRiO26819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 253Pyruvate carboxyltransferasePROSITE-ProRule annotationAdd BLAST251

Sequence similaritiesi

Belongs to the alpha-IPM synthase/homocitrate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02092 Archaea
COG0119 LUCA
KOiK09011
OMAiSNMFAHE
OrthoDBiPOG093Z02P1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01028 CimA, 1 hit
InterProiView protein in InterPro
IPR013709 2-isopropylmalate_synth_dimer
IPR002034 AIPM/Hcit_synth_CS
IPR013785 Aldolase_TIM
IPR024890 Citramalate_synthase_CimA
IPR011830 LEU1_arch
IPR036230 LeuA_allosteric_dom_sf
IPR000891 PYR_CT
PfamiView protein in Pfam
PF00682 HMGL-like, 1 hit
PF08502 LeuA_dimer, 1 hit
SMARTiView protein in SMART
SM00917 LeuA_dimer, 1 hit
SUPFAMiSSF110921 SSF110921, 1 hit
TIGRFAMsiTIGR02090 LEU1_arch, 1 hit
PROSITEiView protein in PROSITE
PS00815 AIPM_HOMOCIT_SYNTH_1, 1 hit
PS00816 AIPM_HOMOCIT_SYNTH_2, 1 hit
PS50991 PYR_CT, 1 hit

Sequencei

Sequence statusi: Complete.

O26819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVRVLDTTL RDGEQTPGVS LTPEEKLRIA LKIDALGADI IEAGSAITSE
60 70 80 90 100
GEREGIRKIT SEGLRAEICS FARAVREDID AAISCDVDSV HLVVPTSDLH
110 120 130 140 150
LEHKLRKTRE EVLEQAVDCT EYAVDHGILV ELSAEDSTRS DMDFLRTIFR
160 170 180 190 200
EGIEAGAERI CACDTVGILT PERSYEFYRG LSELGAPLSV HCHNDFGLAV
210 220 230 240 250
ANSLAGLRAG ASEVHATING IGERAGNAAL EEVVVALKSL YDVDTSINIE
260 270 280 290 300
MLYETSRMVA RMTGVYLQPN KAIVGENAFA HESGIHADGV LKKAETYEPI
310 320 330 340 350
TPEMVGHGRG FVMGKHIGTH ALRKRLDELG MKVADDKLME IFRRVKTLGD
360 370 380 390 400
MGKCVTDVDL QAIAEDVLGV MEDKVVDLQE VTIVSGNRVT PTASVKLRVD
410 420 430 440 450
DREVLEAGTG VGPVDAAIVA IKKSLEDFAD ITLEEYHVDA ITGGTDALID
460 470 480 490
VVIKLRHGDR IISARSTQPD IIMASVEAFL SGVNRLLANE KSEGTH
Length:496
Mass (Da):53,705
Last modified:January 1, 1998 - v1
Checksum:iFCB4D5CDC2F5A115
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85228.1
PIRiF69196
RefSeqiWP_010876362.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85228; AAB85228; MTH_723
GeneIDi1470684
KEGGimth:MTH_723
PATRICifig|187420.15.peg.708

Similar proteinsi

Entry informationi

Entry nameiCIMA_METTH
AccessioniPrimary (citable) accession number: O26819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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