ID   MSRB_METTH              Reviewed;         151 AA.
AC   O26807;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrB;
DE            EC=1.8.4.12;
DE   AltName: Full=Peptide-methionine (R)-S-oxide reductase;
GN   Name=msrB; OrderedLocusNames=MTH_711;
OS   Methanobacterium thermoautotrophicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit. The zinc ion is important
CC       for the structural integrity of the protein (By similarity).
CC   -!- SIMILARITY: Belongs to the msrB Met sulfoxide reductase family.
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DR   EMBL; AE000666; AAB85216.1; -; Genomic_DNA.
DR   PIR; A69195; A69195.
DR   RefSeq; NP_275854.1; -.
DR   PDB; 2K8D; NMR; -; A=1-151.
DR   PDBsum; 2K8D; -.
DR   GeneID; 1470672; -.
DR   GenomeReviews; AE000666_GR; MTH_711.
DR   KEGG; mth:MTH711; -.
DR   NMPDR; fig|187420.1.peg.709; -.
DR   HOGENOM; O26807; -.
DR   OMA; O26807; MVERIEL.
DR   BioCyc; MTHE187420:MTH711-MON; -.
DR   BRENDA; 1.8.4.12; 270.
DR   GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase ac...; IEA:EC.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01400; -; 1.
DR   InterPro; IPR002579; Methionine_sulphoxide_MsrB.
DR   Gene3D; G3DSA:2.170.150.20; MsrB; 1.
DR   Pfam; PF01641; SelR; 1.
DR   ProDom; PD004057; DUF25; 1.
DR   TIGRFAMs; TIGR00357; MsrB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Metal-binding; Oxidoreductase; Zinc.
FT   CHAIN         1    151       Peptide methionine sulfoxide reductase
FT                                msrB.
FT                                /FTId=PRO_0000140320.
FT   ACT_SITE    136    136       Nucleophile (By similarity).
FT   METAL        64     64       Zinc (By similarity).
FT   METAL        67     67       Zinc (By similarity).
FT   METAL       113    113       Zinc (By similarity).
FT   METAL       116    116       Zinc (By similarity).
SQ   SEQUENCE   151 AA;  17303 MW;  8D11C52CEB186033 CRC64;
     MKDRIPIFSV AKNRVEMVER IELSDDEWRE ILDPEAFRVA RKAGTEPPFT GKYHDLHDDG
     IYRCICCGTD LFDSETKFDS GTGWPSFYDV VSEHNIKLRE DRSLGMVRCE VLCARCDAHL
     GHVFDDGPRP TGKRYCMNSA ALKFIPRDQI G
//