O26807 (MSRB_METTH) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 78.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Peptide methionine sulfoxide reductase MsrB EC=1.8.4.12 Alternative name(s): Peptide-methionine (R)-S-oxide reductase | ||||
| Gene names |
| ||||
| Organism | Methanobacterium thermoautotrophicum (strain Delta H) | ||||
| Taxonomic identifier | 187420 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter |
Protein attributes
| Sequence length | 151 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400 |
| Cofactor | Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity. |
| Sequence similarities | Belongs to the MsrB Met sulfoxide reductase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Zinc |
| Molecular function | Oxidoreductase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activityInferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 151 | 151 | Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400 | PRO_0000140320 | |||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||
| Active site | 136 | 1 | Nucleophile By similarity | ||||||||||||||||||||||||||||
| Metal binding | 64 | 1 | Zinc By similarity | ||||||||||||||||||||||||||||
| Metal binding | 67 | 1 | Zinc By similarity | ||||||||||||||||||||||||||||
| Metal binding | 113 | 1 | Zinc By similarity | ||||||||||||||||||||||||||||
| Metal binding | 116 | 1 | Zinc By similarity | ||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||
| Beta strand | 4 – 7 | 4 | |||||||||||||||||||||||||||||
| Helix | 10 – 12 | 3 | |||||||||||||||||||||||||||||
| Beta strand | 16 – 19 | 4 | |||||||||||||||||||||||||||||
| Helix | 27 – 29 | 3 | |||||||||||||||||||||||||||||
| Helix | 36 – 42 | 7 | |||||||||||||||||||||||||||||
| Beta strand | 62 – 64 | 3 | |||||||||||||||||||||||||||||
| Helix | 74 – 76 | 3 | |||||||||||||||||||||||||||||
| Beta strand | 86 – 88 | 3 | |||||||||||||||||||||||||||||
| Beta strand | 95 – 97 | 3 | |||||||||||||||||||||||||||||
| Beta strand | 134 – 136 | 3 | |||||||||||||||||||||||||||||
| Beta strand | 142 – 144 | 3 | |||||||||||||||||||||||||||||
Sequences
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References
| [1] | "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. Reeve J.N.J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AE000666 Genomic DNA. Translation: AAB85216.1. | ||||||||||||
| PIR | A69195. | ||||||||||||
| RefSeq | NP_275854.1. NC_000916.1. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | O26807. | ||||||||||||
| SMR | O26807. Positions 21-147. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | O26807. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| GeneID | 1470672. | ||||||||||||
| GenomeReviews | Gene locus MTH_711 in contig AE000666_GR. | ||||||||||||
| KEGG | mth:MTH711. | ||||||||||||
| NMPDR | fig|187420.1.peg.709. | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | arNOG10043. | ||||||||||||
| HOGENOM | HBG715255. | ||||||||||||
| OMA | PSFWDVY. | ||||||||||||
| PhylomeDB | O26807. | ||||||||||||
| ProtClustDB | PRK00222. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | MTHE187420:MTH711-MONOMER. | ||||||||||||
Family and domain databases | |||||||||||||
| HAMAP | MF_01400. MsrB. [Tree] | ||||||||||||
| InterPro | IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:2.170.150.20. MsrB. 1 hit. | ||||||||||||
| KO | K07305. | ||||||||||||
| Pfam | PF01641. SelR. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF51316. Mss4_like. 1 hit. | ||||||||||||
| TIGRFAMs | TIGR00357. TIGR00357. 1 hit. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | MSRB_METTH | ||||||||
| Accession | Primary (citable) accession number: O26807 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with