Reviewed, UniProtKB/Swiss-Prot O26807 (MSRB_METTH)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	MTH_711

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	Peptide methionine sulfoxide reductase msrB HAMAP MF_01400		PRO_0000140320
Sites
	Active site	136	1	Nucleophile By similarity
	Metal binding	64	1	Zinc By similarity
	Metal binding	67	1	Zinc By similarity
	Metal binding	113	1	Zinc By similarity
	Metal binding	116	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	O26807-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 8D11C52CEB186033	FASTA	151	17,303
	10 20 30 40 50 60 MKDRIPIFSV AKNRVEMVER IELSDDEWRE ILDPEAFRVA RKAGTEPPFT GKYHDLHDDG 70 80 90 100 110 120 IYRCICCGTD LFDSETKFDS GTGWPSFYDV VSEHNIKLRE DRSLGMVRCE VLCARCDAHL 130 140 150 GHVFDDGPRP TGKRYCMNSA ALKFIPRDQI G

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE000666 Genomic DNA. Translation: AAB85216.1.

PIR

A69195.

RefSeq

NP_275854.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K8D	NMR	-	A	1-151	[»]

ModBase

Search...

Genome annotation databases

GeneID

1470672.

GenomeReviews

Gene locus MTH_711 in contig AE000666_GR.

KEGG

mth:MTH711.

NMPDR

fig|187420.1.peg.709.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

O26807.

OMA

O26807. MVERIEL.

Enzyme and pathway databases

BioCyc

MTHE187420:MTH711-MON.

BRENDA

1.8.4.12. 270.

Family and domain databases

HAMAP

MF_01400.
[Tree]

InterPro

IPR002579. Methionine_sulphoxide_MsrB.
[Graphical view]

Gene3D

G3DSA:2.170.150.20. MsrB. 1 hit.

Pfam

PF01641. SelR. 1 hit.
[Graphical view]

ProDom

PD004057. DUF25. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR00357. MsrB. 1 hit.

ProtoNet

Search...

Entry information

Entry name

MSRB_METTH

Accession

Primary (citable) accession number: O26807

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)