Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641ZincPROSITE-ProRule annotation
Metal bindingi67 – 671ZincPROSITE-ProRule annotation
Metal bindingi113 – 1131ZincPROSITE-ProRule annotation
Metal bindingi116 – 1161ZincPROSITE-ProRule annotation
Active sitei136 – 1361NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-713-MONOMER.
BRENDAi1.8.4.12. 3256.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Ordered Locus Names:MTH_711
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151Peptide methionine sulfoxide reductase MsrBPRO_0000140320Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH711.

Structurei

Secondary structure

1
151
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi10 – 123Combined sources
Beta strandi16 – 194Combined sources
Helixi27 – 293Combined sources
Helixi36 – 427Combined sources
Beta strandi46 – 483Combined sources
Beta strandi60 – 645Combined sources
Turni65 – 673Combined sources
Beta strandi70 – 734Combined sources
Helixi74 – 763Combined sources
Beta strandi85 – 884Combined sources
Beta strandi95 – 973Combined sources
Beta strandi108 – 1136Combined sources
Beta strandi116 – 12510Combined sources
Beta strandi127 – 1315Combined sources
Beta strandi133 – 1375Combined sources
Beta strandi142 – 1454Combined sources
Beta strandi147 – 1493Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K8DNMR-A1-151[»]
ProteinModelPortaliO26807.
SMRiO26807. Positions 21-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO26807.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 147123MsrBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG02815. Archaea.
COG0229. LUCA.
KOiK07305.
OMAiRMQYEVT.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRIPIFSV AKNRVEMVER IELSDDEWRE ILDPEAFRVA RKAGTEPPFT
60 70 80 90 100
GKYHDLHDDG IYRCICCGTD LFDSETKFDS GTGWPSFYDV VSEHNIKLRE
110 120 130 140 150
DRSLGMVRCE VLCARCDAHL GHVFDDGPRP TGKRYCMNSA ALKFIPRDQI

G
Length:151
Mass (Da):17,303
Last modified:January 1, 1998 - v1
Checksum:i8D11C52CEB186033
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85216.1.
PIRiA69195.
RefSeqiWP_010876350.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85216; AAB85216; MTH_711.
GeneIDi24853853.
KEGGimth:MTH_711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85216.1.
PIRiA69195.
RefSeqiWP_010876350.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K8DNMR-A1-151[»]
ProteinModelPortaliO26807.
SMRiO26807. Positions 21-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH711.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85216; AAB85216; MTH_711.
GeneIDi24853853.
KEGGimth:MTH_711.

Phylogenomic databases

eggNOGiarCOG02815. Archaea.
COG0229. LUCA.
KOiK07305.
OMAiRMQYEVT.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-713-MONOMER.
BRENDAi1.8.4.12. 3256.

Miscellaneous databases

EvolutionaryTraceiO26807.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiMSRB_METTH
AccessioniPrimary (citable) accession number: O26807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.