Reviewed,
UniProtKB/Swiss-Prot O26806 (GUAAB_METTH)
Last modified
September 22, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: GMP synthase [glutamine-hydrolyzing] subunit B EC=6.3.5.2 Alternative name(s): GMP synthetase | ||||
| Gene names |
| ||||
| Organism | Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 187420 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter |
Protein attributes
| Sequence length | 308 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the synthesis of GMP from XMP By similarity. |
| Catalytic activity | ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00345 |
| Pathway | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00345 |
| Subunit structure | Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential. |
| Sequence similarities | Contains 1 GMP-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | GMP biosynthesis Purine biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | GMP biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP GMP synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 308 | 308 | GMP synthase [glutamine-hydrolyzing] subunit B HAMAP MF_00345 | PRO_0000140245 | |||||
Regions | |||||||||
| Domain | 33 – 184 | 152 | GMP-binding | ||||||
| Nucleotide binding | 29 – 35 | 7 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. Reeve J.N.J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H. |
Cross-references
Sequence databases | |
|---|---|
| AE000666 Genomic DNA. Translation: AAB85215.1. Different initiation. | |
| PIR | H69194. |
| RefSeq | NP_275853.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GPM based on UniProtKB P04079. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O26806. |
Genome annotation databases | |
| GeneID | 1470671. |
| GenomeReviews | Gene locus MTH_710 in contig AE000666_GR. |
| KEGG | mth:MTH710. |
| NMPDR | fig|187420.1.peg.708. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O26806. |
Enzyme and pathway databases | |
| BioCyc | MTHE187420:MTH710-MON. |
| BRENDA | 6.3.5.2. 270. |
Family and domain databases | |
| HAMAP | MF_00345. [Tree] |
| InterPro | IPR001674. GMP_synth_C. IPR014729. Rossmann-like_a/b/a_fold. IPR018318. tRNA_MeTrfase-like. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| Pfam | PF00958. GMP_synt_C. 1 hit. PF03054. tRNA_Me_trans. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00884. guaA_Cterm. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GUAAB_METTH | ||||||||
| Accession | Primary (citable) accession number: O26806 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


