ID   VORA_METTH              Reviewed;         477 AA.
AC   O26801;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit vorA;
DE            Short=VOR;
DE            EC=1.2.7.7;
DE   AltName: Full=2-oxoisovalerate oxidoreductase alpha chain;
DE   AltName: Full=2-oxoisovalerate ferredoxin reductase subunit alpha;
GN   Name=vorA; OrderedLocusNames=MTH_705;
OS   Methanobacterium thermoautotrophicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized
CC       ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- SUBUNIT: Heterotrimer of the vorA, vorB and vorC subunits (By
CC       similarity).
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DR   EMBL; AE000666; AAB85210.1; -; Genomic_DNA.
DR   PIR; B69194; B69194.
DR   RefSeq; NP_275848.1; -.
DR   GeneID; 1470666; -.
DR   GenomeReviews; AE000666_GR; MTH_705.
DR   KEGG; mth:MTH705; -.
DR   NMPDR; fig|187420.1.peg.703; -.
DR   HOGENOM; O26801; -.
DR   OMA; O26801; VFAYYYF.
DR   BioCyc; MTHE187420:MTH705-MON; -.
DR   BRENDA; 1.2.7.7; 270.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferr...; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamin pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed.
DR   InterPro; IPR011766; TPP_enzyme_bd_C.
DR   Gene3D; G3DSA:3.40.920.10; Pyrv_Fd/Flavodoxin_OxRdtase; 1.
DR   Pfam; PF01558; POR; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    477       Ketoisovalerate oxidoreductase subunit
FT                                vorA.
FT                                /FTId=PRO_0000099949.
SQ   SEQUENCE   477 AA;  51628 MW;  FFDF19226C40790A CRC64;
     MTKKVIRKPD SLHDVFERKG GSAPTATHYC AGCGHGILHK LIGEAMDELG IQERAVMISP
     VGCAVFAYYY FDCGNVQVAH GRAPAVGTGI SRAEDDAVVI LYQGDGDLAS IGLNETIQAA
     NRGEKLAVFF VNNTVYGMTG GQMAPTTLVG EVTVTCPTGR DPRYAGYPLH MCELLDNLQA
     PVFIERVSLA DPKRIRRARR AIKRALEIQR DGKGYAFVEV LSPCPTNLRQ DAEGAERFLK
     EEMEKEFPVK NFRDRSAETE PLIRSESDFS RESLDRIFQI REDSVPDPVD DPEFPEVRVK
     IAGFGGQGVL SMGLTLAQAA CSEGRHTSWY PAYGPEQRGG TSSCGVVISG ERVGSPAVDT
     PDVLVALNQP SLDEFADDVA DGGIILYDST TASFSGGAVR AMGVPALEIA RKHGTARAAN
     TVMLGVMMAL GLTGLDEESF REAIKFTFAG KEKIIDMNLR ILEAGAEWAR ENIEGEL
//