O26801 (VORA_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketoisovalerate oxidoreductase subunit vorA
Short name=VOR
EC=1.2.7.7

Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit alpha
2-oxoisovalerate oxidoreductase alpha chain

Gene names

Name:	vorA
Ordered Locus Names:	MTH_705

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotrimer of the vorA, vorB and vorC subunits By similarity.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 477	476	Ketoisovalerate oxidoreductase subunit vorA		PRO_0000099949

Sequences

	Sequence		Length	Mass (Da)
	O26801 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: FFDF19226C40790A	FASTA	477	51,628
	10 20 30 40 50 60 MTKKVIRKPD SLHDVFERKG GSAPTATHYC AGCGHGILHK LIGEAMDELG IQERAVMISP 70 80 90 100 110 120 VGCAVFAYYY FDCGNVQVAH GRAPAVGTGI SRAEDDAVVI LYQGDGDLAS IGLNETIQAA 130 140 150 160 170 180 NRGEKLAVFF VNNTVYGMTG GQMAPTTLVG EVTVTCPTGR DPRYAGYPLH MCELLDNLQA 190 200 210 220 230 240 PVFIERVSLA DPKRIRRARR AIKRALEIQR DGKGYAFVEV LSPCPTNLRQ DAEGAERFLK 250 260 270 280 290 300 EEMEKEFPVK NFRDRSAETE PLIRSESDFS RESLDRIFQI REDSVPDPVD DPEFPEVRVK 310 320 330 340 350 360 IAGFGGQGVL SMGLTLAQAA CSEGRHTSWY PAYGPEQRGG TSSCGVVISG ERVGSPAVDT 370 380 390 400 410 420 PDVLVALNQP SLDEFADDVA DGGIILYDST TASFSGGAVR AMGVPALEIA RKHGTARAAN 430 440 450 460 470 TVMLGVMMAL GLTGLDEESF REAIKFTFAG KEKIIDMNLR ILEAGAEWAR ENIEGEL

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85210.1.
PIR	B69194.
RefSeq	NP_275848.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26801.
ModBase	Search...
Protein-protein interaction databases
STRING	O26801.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470666.
GenomeReviews	Gene locus MTH_705 in contig AE000666_GR.
KEGG	mth:MTH705.
NMPDR	fig|187420.1.peg.703.
Phylogenomic databases
eggNOG	arNOG05024.
HOGENOM	HBG310922.
OMA	VFAYYYF.
ProtClustDB	CLSK878486.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH705-MONOMER.
Family and domain databases
InterPro	IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. IPR011766. TPP_enzyme-bd_C. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
KO	K00187.
Pfam	PF01558. POR. 1 hit. PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
SUPFAM	SSF53323. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VORA_METTH

Accession

Primary (citable) accession number: O26801

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program