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Reviewed, UniProtKB/Swiss-Prot O26801 (VORA_METTH)

Last modified November 3, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesRecommended name:
    Ketoisovalerate oxidoreductase subunit vorA
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase alpha chain
    2-oxoisovalerate ferredoxin reductase subunit alpha
Gene names
Name: vorA
Ordered Locus Names: MTH_705
OrganismMethanobacterium thermoautotrophicum [Complete proteome] [HAMAP]
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.

Subunit structure

Heterotrimer of the vorA, vorB and vorC subunits By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 477476Ketoisovalerate oxidoreductase subunit vorA
PRO_0000099949

Sequences

Sequence LengthMass (Da)Tools
O26801-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FFDF19226C40790A

FASTA47751,628
        10         20         30         40         50         60 
MTKKVIRKPD SLHDVFERKG GSAPTATHYC AGCGHGILHK LIGEAMDELG IQERAVMISP 

        70         80         90        100        110        120 
VGCAVFAYYY FDCGNVQVAH GRAPAVGTGI SRAEDDAVVI LYQGDGDLAS IGLNETIQAA 

       130        140        150        160        170        180 
NRGEKLAVFF VNNTVYGMTG GQMAPTTLVG EVTVTCPTGR DPRYAGYPLH MCELLDNLQA 

       190        200        210        220        230        240 
PVFIERVSLA DPKRIRRARR AIKRALEIQR DGKGYAFVEV LSPCPTNLRQ DAEGAERFLK 

       250        260        270        280        290        300 
EEMEKEFPVK NFRDRSAETE PLIRSESDFS RESLDRIFQI REDSVPDPVD DPEFPEVRVK 

       310        320        330        340        350        360 
IAGFGGQGVL SMGLTLAQAA CSEGRHTSWY PAYGPEQRGG TSSCGVVISG ERVGSPAVDT 

       370        380        390        400        410        420 
PDVLVALNQP SLDEFADDVA DGGIILYDST TASFSGGAVR AMGVPALEIA RKHGTARAAN 

       430        440        450        460        470 
TVMLGVMMAL GLTGLDEESF REAIKFTFAG KEKIIDMNLR ILEAGAEWAR ENIEGEL 

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References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.

Cross-references

Sequence databases

AE000666 Genomic DNA. Translation: AAB85210.1.
PIRB69194.
RefSeqNP_275848.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO26801.

Genome annotation databases

GeneID1470666.
GenomeReviewsGene locus MTH_705 in contig AE000666_GR.
KEGGmth:MTH705.
NMPDRfig|187420.1.peg.703.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMO26801.
OMAVFAYYYF.

Enzyme and pathway databases

BioCycMTHE187420:MTH705-MON.
BRENDA1.2.7.7. 270.

Family and domain databases

InterProIPR019752. Pyrv/ketoisovalerate_OxRed.
IPR011766. TPP_enzyme_bd_C.
[Graphical view]
Gene3DG3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
PfamPF01558. POR. 1 hit.
PF02775. TPP_enzyme_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVORA_METTH
AccessionPrimary (citable) accession number: O26801
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 3, 2009
This is version 56 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information