ID   VORB_METTH              Reviewed;         352 AA.
AC   O26800;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   20-JAN-2009, entry version 52.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit vorB;
DE            Short=VOR;
DE            EC=1.2.7.7;
DE   AltName: Full=2-oxoisovalerate oxidoreductase beta chain;
DE   AltName: Full=2-oxoisovalerate ferredoxin reductase subunit beta;
GN   Name=vorB; OrderedLocusNames=MTH_704;
OS   Methanobacterium thermoautotrophicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized
CC       ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- SUBUNIT: Heterotrimer of the vorA, vorB and vorC subunits.
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DR   EMBL; AE000666; AAB85209.1; ALT_INIT; Genomic_DNA.
DR   PIR; A69194; A69194.
DR   RefSeq; NP_275847.1; -.
DR   GeneID; 1470665; -.
DR   GenomeReviews; AE000666_GR; MTH_704.
DR   KEGG; mth:MTH704; -.
DR   NMPDR; fig|187420.1.peg.702; -.
DR   HOGENOM; O26800; -.
DR   BioCyc; MTHE187420:MTH704-MON; -.
DR   BRENDA; 1.2.7.7; 270.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferr...; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR015941; Transketolase_C-like.
DR   Gene3D; G3DSA:3.40.50.920; Transketo_C_like; 1.
DR   Pfam; PF01855; POR_N; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    352       Ketoisovalerate oxidoreductase subunit
FT                                vorB.
FT                                /FTId=PRO_0000099954.
SQ   SEQUENCE   352 AA;  38628 MW;  AE27D675608258A8 CRC64;
     MATQMVKGNT AVIIGAMYAG CDCYFGYPIT PASEILHEAS RYFPMVGRKF VQAESEEAAI
     NMVYGAAAAG HRVMTASSGP GISLKQEGIS FLAGAELPAV IVDVMRAGPG LGNIGPEQGD
     YNQIVKGGGH GNYRNMVLAP SSVQEMCDLT MEAFELADKY RNPVVVLTDA VLGQMAEPLR
     FPEEAVEHRP DTSWAVCGNR ETMKNLVTSI FLDFDELEEF NFYLQEKYAR IEENEVRYEE
     YLVDDAEIVM VAYGISSRVA RSAVETARAE GINVGLLRPI TLFPFPSDRI RELADGGCRF
     ISVEMSSGQM REDIRMASGC RDVELVNRMG GNLIELRDVL EKIREVAGDS SD
//