Reviewed, UniProtKB/Swiss-Prot O26800 (VORB_METTH)

Names and origin

Protein names

Recommended name:
    Ketoisovalerate oxidoreductase subunit vorB
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase beta chain
    2-oxoisovalerate ferredoxin reductase subunit beta

Gene names

Name:	vorB
Ordered Locus Names:	MTH_704

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotrimer of the vorA, vorB and vorC subunits.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 352	351	Ketoisovalerate oxidoreductase subunit vorB		PRO_0000099954

Sequences

	Sequence		Length	Mass (Da)
	O26800-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: AE27D675608258A8	FASTA	352	38,628
	10 20 30 40 50 60 MATQMVKGNT AVIIGAMYAG CDCYFGYPIT PASEILHEAS RYFPMVGRKF VQAESEEAAI 70 80 90 100 110 120 NMVYGAAAAG HRVMTASSGP GISLKQEGIS FLAGAELPAV IVDVMRAGPG LGNIGPEQGD 130 140 150 160 170 180 YNQIVKGGGH GNYRNMVLAP SSVQEMCDLT MEAFELADKY RNPVVVLTDA VLGQMAEPLR 190 200 210 220 230 240 FPEEAVEHRP DTSWAVCGNR ETMKNLVTSI FLDFDELEEF NFYLQEKYAR IEENEVRYEE 250 260 270 280 290 300 YLVDDAEIVM VAYGISSRVA RSAVETARAE GINVGLLRPI TLFPFPSDRI RELADGGCRF 310 320 330 340 350 ISVEMSSGQM REDIRMASGC RDVELVNRMG GNLIELRDVL EKIREVAGDS SD

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000666 Genomic DNA. Translation: AAB85209.1. Different initiation.
PIR	A69194.
RefSeq	NP_275847.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1470665.
GenomeReviews	Gene locus MTH_704 in contig AE000666_GR.
KEGG	mth:MTH704.
NMPDR	fig|187420.1.peg.702.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O26800.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH704-MON.
BRENDA	1.2.7.7. 270.
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR015941. Transketolase_C-like. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF01855. POR_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORB_METTH

Accession

Primary (citable) accession number: O26800

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	January 20, 2009
This is version 52 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)