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O26800 (VORB_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketoisovalerate oxidoreductase subunit vorB
Short name=VOR
EC=1.2.7.7
Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit beta
2-oxoisovalerate oxidoreductase beta chain
Gene names
Name:vorB
Ordered Locus Names:MTH_704
OrganismMethanobacterium thermoautotrophicum (strain Delta H)
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.

Subunit structure

Heterotrimer of the vorA, vorB and vorC subunits.

Sequence caution

The sequence AAB85209.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular function3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 352351Ketoisovalerate oxidoreductase subunit vorB
PRO_0000099954

Sequences

Sequence LengthMass (Da)Tools
O26800 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: AE27D675608258A8

FASTA35238,628
        10         20         30         40         50         60 
MATQMVKGNT AVIIGAMYAG CDCYFGYPIT PASEILHEAS RYFPMVGRKF VQAESEEAAI 

        70         80         90        100        110        120 
NMVYGAAAAG HRVMTASSGP GISLKQEGIS FLAGAELPAV IVDVMRAGPG LGNIGPEQGD 

       130        140        150        160        170        180 
YNQIVKGGGH GNYRNMVLAP SSVQEMCDLT MEAFELADKY RNPVVVLTDA VLGQMAEPLR 

       190        200        210        220        230        240 
FPEEAVEHRP DTSWAVCGNR ETMKNLVTSI FLDFDELEEF NFYLQEKYAR IEENEVRYEE 

       250        260        270        280        290        300 
YLVDDAEIVM VAYGISSRVA RSAVETARAE GINVGLLRPI TLFPFPSDRI RELADGGCRF 

       310        320        330        340        350 
ISVEMSSGQM REDIRMASGC RDVELVNRMG GNLIELRDVL EKIREVAGDS SD

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References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000666 Genomic DNA. Translation: AAB85209.1. Different initiation.
PIRA69194.
RefSeqNP_275847.1. NC_000916.1.

3D structure databases

ProteinModelPortalO26800.
ModBaseSearch...

Protein-protein interaction databases

STRINGO26800.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1470665.
GenomeReviewsGene locus MTH_704 in contig AE000666_GR.
KEGGmth:MTH704.
NMPDRfig|187420.1.peg.702.

Phylogenomic databases

eggNOGarNOG05023.
HOGENOMHBG399087.
OMACVIVNIM.
ProtClustDBPRK07119.

Enzyme and pathway databases

BioCycMTHE187420:MTH704-MONOMER.

Family and domain databases

InterProIPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00186.
PfamPF01855. POR_N. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVORB_METTH
AccessionPrimary (citable) accession number: O26800
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 16, 2011
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
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