Reviewed, UniProtKB/Swiss-Prot O26799 (VORC_METTH)

Names and origin

Protein names

Recommended name:
    Ketoisovalerate oxidoreductase subunit vorC
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase gamma chain
    2-oxoisovalerate ferredoxin reductase subunit gamma

Gene names

Name:	vorC
Ordered Locus Names:	MTH_703

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Cofactor	Binds 2 4Fe-4S clusters By similarity.
Subunit structure	Heterotrimer of the vorA, vorB and vorC subunits.
Sequence similarities	Contains 2 4Fe-4S ferredoxin-type domains.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Repeat
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 79	79	Ketoisovalerate oxidoreductase subunit vorC		PRO_0000099959
Regions
	Domain	4 – 33	30	4Fe-4S ferredoxin-type 1
	Domain	40 – 70	31	4Fe-4S ferredoxin-type 2
Sites
	Metal binding	13	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	16	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	19	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	23	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	49	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	52	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	55	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	59	1	Iron-sulfur 1 (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	O26799-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9DFE9CC6A2AE943E	FASTA	79	8,928
	10 20 30 40 50 60 MKKAYPVINS VECKACERCI IACPRKVLQM SSKINERGYH YVEYRGEGCN GCGNCYYTCP 70 EINAIEVHIE RCEDGNTDG

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85208.1.
PIR	H69193.
RefSeq	NP_275846.1.
3D structure databases
SMR	O26799. Positions 5-69.
ModBase	Search...
Protein-protein interaction databases
STRING	O26799.
Genome annotation databases
GeneID	1470664.
GenomeReviews	Gene locus MTH_703 in contig AE000666_GR.
KEGG	mth:MTH703.
NMPDR	fig|187420.1.peg.701.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG11506.
HOGENOM	HBG734156.
OMA	YTCPEPL.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH703-MONOMER.
BRENDA	1.2.7.7. 270.
Family and domain databases
InterPro	IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. [Graphical view]
PROSITE	PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORC_METTH

Accession

Primary (citable) accession number: O26799

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	January 19, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)