ID   O26797_METTH            Unreviewed;       425 AA.
AC   O26797;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 105.
DE   SubName: Full=Acetyl-CoA synthetase related protein {ECO:0000313|EMBL:AAB85206.1};
GN   OrderedLocusNames=MTH_701 {ECO:0000313|EMBL:AAB85206.1};
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420 {ECO:0000313|EMBL:AAB85206.1, ECO:0000313|Proteomes:UP000005223};
RN   [1] {ECO:0000313|EMBL:AAB85206.1, ECO:0000313|Proteomes:UP000005223}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H
RC   {ECO:0000313|Proteomes:UP000005223};
RX   PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-i., Rice P., Nolling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; AE000666; AAB85206.1; -; Genomic_DNA.
DR   PIR; F69193; F69193.
DR   AlphaFoldDB; O26797; -.
DR   STRING; 187420.MTH_701; -.
DR   PaxDb; 187420-MTH_701; -.
DR   EnsemblBacteria; AAB85206; AAB85206; MTH_701.
DR   KEGG; mth:MTH_701; -.
DR   PATRIC; fig|187420.15.peg.684; -.
DR   HOGENOM; CLU_000022_59_10_2; -.
DR   InParanoid; O26797; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005223}.
FT   DOMAIN          40..413
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   425 AA;  48552 MW;  2EDBC5F833838D1C CRC64;
     MTALINEFVN RVEFDSYEDF RDNFRINVPE NFNFAYDVVD RYAEIEPDKV ALVWCNDHGE
     EKRITFGELR DLSSRAANFF TKEGIQKGDT VMLTLKARYD FWYALLGLHR IGAIAIPATH
     MLKEKDIVYR IREADIKMVV CIAEDGVPEV FEGAIAELGS DTRRVLVGDT DRDGWINLRK
     EIMKLPADFE RPEACAGGDD TLIVYFSSGT TGMPKMIEHD HTYPLGHIIT AKYWQNVRED
     GLHYTVADTG WAKAMWGQIY GQWIAGSAVF VYDYDRFDPE KMLEKLEKYE ITTFCAPPTI
     YRFLIKEDLS RYDLSGIEYA VTAGEPLNPE VFERFREHTG LQLMEGFGQT ECVVCIANFP
     WMEPKPGSMG KPSPGYPVEL VDRNGDPVDV GEEGEIVIRT AEGKPLGLFN GYYRNPEKTS
     EVWHD
//