O26784 (RNP3_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component 3
Short name=RNase P component 3
EC=3.1.26.5

Gene names

Name:	rnp3
Ordered Locus Names:	MTH_688

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. HAMAP MF_00756
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00756
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: InterPro
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Ribonuclease P protein component 3 HAMAP MF_00756		PRO_0000140043

Sequences

	Sequence		Length	Mass (Da)
	O26784 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B86C15C0495F957E	FASTA	245	27,680
	10 20 30 40 50 60 MIPQRILMKF FDFHIQGRDH DSSLRLLLEA SRLGYQGGVL VYPSERYPDL KSDLESLREN 70 80 90 100 110 120 PELQDFEIAR GVMINASDPR DMRRSVNKFR KKADVIYVSG GNLKVNRAAC ESRRVDVLSA 130 140 150 160 170 180 PYTSRRDPGI NHVLAREAAR NNVAVELPLA DVIGSWLKVR ARVLEQFREI LKLHRKFGFP 190 200 210 220 230 240 LLLTSRASSI YDLRTPGDIM NLAECFGMES SEAEESLTST PASILEDSGN RHLLIAEGVR LLPES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.
[2]	"Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins." Hall T.A., Brown J.W. RNA 8:296-306(2002) [PubMed: 12003490] [Abstract] Cited for: CHARACTERIZATION. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85193.1.
PIR	F69191.
RefSeq	NP_275831.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26784.
ModBase	Search...
Protein-protein interaction databases
IntAct	O26784. 1 interaction.
STRING	O26784.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470649.
GenomeReviews	Gene locus MTH_688 in contig AE000666_GR.
KEGG	mth:MTH688.
NMPDR	fig|187420.1.peg.686.
Phylogenomic databases
eggNOG	arNOG09152.
HOGENOM	HBG551632.
OMA	FKEDARI.
ProtClustDB	PRK00912.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH688-MONOMER.
Family and domain databases
HAMAP	MF_00756. RNase_P_3. [Tree]
InterPro	IPR016195. Pol/histidinol_Pase-like. IPR023539. RNase_P_comp-3. IPR002738. RNase_P_p30. [Graphical view]
KO	K03539.
Pfam	PF01876. RNase_P_p30. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNP3_METTH

Accession

Primary (citable) accession number: O26784

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program