O26783 (RNP2_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component 2
Short name=RNase P component 2
EC=3.1.26.5

Gene names

Name:	rnp2
Ordered Locus Names:	MTH_687

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. HAMAP MF_00755
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00755
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: InterPro
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Ribonuclease P protein component 2 HAMAP MF_00755		PRO_0000140024

Sequences

	Sequence		Length	Mass (Da)
	O26783 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 5034454559C101A6	FASTA	124	14,568
	10 20 30 40 50 60 MKILPPTLRV PRRYIAFEVI SERELSREEL VSLIWDSCLK LHGECETSNF RLWLMKLWRF 70 80 90 100 110 120 DFPDAVRVRG ILQCQRGYER RVMMALTCAH HHSGVRVAIH ILGLSGTIRS ATQKFIKPSK KDKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.
[2]	"Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins." Hall T.A., Brown J.W. RNA 8:296-306(2002) [PubMed: 12003490] [Abstract] Cited for: CHARACTERIZATION. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85192.1.
PIR	E69191.
RefSeq	NP_275830.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26783.
ModBase	Search...
Protein-protein interaction databases
IntAct	O26783. 1 interaction.
STRING	O26783.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470648.
GenomeReviews	Gene locus MTH_687 in contig AE000666_GR.
KEGG	mth:MTH687.
NMPDR	fig|187420.1.peg.685.
Phylogenomic databases
eggNOG	arNOG12799.
HOGENOM	HBG551631.
OMA	NPWLIDY.
ProtClustDB	CLSK2558351.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH687-MONOMER.
Family and domain databases
HAMAP	MF_00755. RNase_P_2. [Tree]
InterPro	IPR002759. RNase_P/MRP_subunit. IPR016434. RNase_P_comp-2. [Graphical view]
KO	K03537.
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
PIRSF	PIRSF004952. RNase_P_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNP2_METTH

Accession

Primary (citable) accession number: O26783

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program