Reviewed, UniProtKB/Swiss-Prot O26518 (APGM2_METTH)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2
      Short name=Phosphoglyceromutase 2
      Short name=BPG-independent PGAM 2
      Short name=aPGAM 2
    EC=5.4.2.1

Gene names

Name:	apgM2
Ordered Locus Names:	MTH_418

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 HAMAP MF_01402		PRO_0000138140

Sequences

	Sequence		Length	Mass (Da)
	O26518-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: EB5EF3B8A18E7617	FASTA	402	44,100
	10 20 30 40 50 60 MITMKHVILV GDGMADYPLD ELDGKTPLQV ADKPNMDQLA GMGACGLLRT VPEGMEAGSD 70 80 90 100 110 120 VANLSIMGYD PRRYYTGRGP LEAASIGVEL GDDDVAFRCN LINADERIVD FNAGHIETAE 130 140 150 160 170 180 ASSLIDALNH ELETRGRFYA GVSYRNLFVI EGRGYTSVRV EPPHDIVGES VAAHLPSGSE 190 200 210 220 230 240 EADHIRELML ESAGVLRSHE VNLKRESMGK RPATMIWLWG QGLRPSMEPF SERYGIRGAT 250 260 270 280 290 300 ITAVDLIKGL GVYAGLENIH VPGATGYLDT DYRAKGRYAA GALEEYDFLY VHVEAPDEAG 310 320 330 340 350 360 HAGDAEEKIR AIENIDRFVL GRLLDALSDH EHRIAVLPDH PTPIEIRTHV PDPVPCILAG 370 380 390 400 DGVDADQVKS YDEFTVREGS LGTWEAHRLM EIMMDPAARL RQ

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000666 Genomic DNA. Translation: AAB84924.1.
PIR	D69154.
RefSeq	NP_275561.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O26518.
Genome annotation databases
GeneID	1470379.
GenomeReviews	Gene locus MTH_418 in contig AE000666_GR.
KEGG	mth:MTH418.
NMPDR	fig|187420.1.peg.416.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O26518.
OMA	GATGYLD.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH418-MON.
BRENDA	5.4.2.1. 270.
Family and domain databases
HAMAP	MF_01402. [Tree]
InterPro	IPR004456. APGAM_arc. IPR019304. bisP-indep_Pglycerate_Mutase. IPR013371. Homoserine_kin_put. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
ProDom	PD004704. APGAM_DeoB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00306. apgM. 1 hit. TIGR02535. hyp_Hser_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM2_METTH

Accession

Primary (citable) accession number: O26518

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)