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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPBy similarity8
Nucleotide bindingi88 – 92GTPBy similarity5
Nucleotide bindingi144 – 147GTPBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Ordered Locus Names:MTH_261
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374581 – 408Translation initiation factor 2 subunit gammaAdd BLAST408

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi187420.MTH261.

Structurei

3D structure databases

ProteinModelPortaliO26361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 201tr-type GAdd BLAST198

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 20G1By similarity8
Regioni41 – 45G2By similarity5
Regioni88 – 91G3By similarity4
Regioni144 – 147G4By similarity4
Regioni179 – 181G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNQSEINIG LVGHVDHGKT TLTKALSGVW TDTHSEETKR GISIRLGYAD
60 70 80 90 100
ITFRKCPQCE APMCYTTAEI CERCGTETEL LRKVSFVDAP GHETLMATML
110 120 130 140 150
SGAALMDGAI LVIAANEPCP QPQTKEHLMA LDVIGVKDVI VVQNKIDIVS
160 170 180 190 200
KERALESYRE IKEFVKGTCA EDAPIIPVSA QQGANIDILI ETIEERIKTP
210 220 230 240 250
KRDVDKPARM YVARSFDINK PGADPEHLAG GVIGGSLVQG RLRVGDEIEI
260 270 280 290 300
RPGIQVKKDG KQTWMSLHST ITGLVAGGEE MEEVGPGGLV GVGTLLDPAL
310 320 330 340 350
TKADSLSGSV AGEPGTLPPV RHSFTMETHL LERVVGTKEE TKVEPIKTGE
360 370 380 390 400
PLMINVGTTT TVGVVKSARA DDADVVLKLP ACAEEGQRIA LSRRVGARWR

LIGYGIIK
Length:408
Mass (Da):43,898
Last modified:January 1, 1998 - v1
Checksum:iE913B1A2CCBA6917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84767.1.
PIRiH69132.
RefSeqiWP_010875900.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84767; AAB84767; MTH_261.
GeneIDi1470222.
KEGGimth:MTH_261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84767.1.
PIRiH69132.
RefSeqiWP_010875900.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO26361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84767; AAB84767; MTH_261.
GeneIDi1470222.
KEGGimth:MTH_261.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2G_METTH
AccessioniPrimary (citable) accession number: O26361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.