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Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTPBy similarity
Nucleotide bindingi76 – 805GTPBy similarity
Nucleotide bindingi130 – 1334GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:MTH_259
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Probable translation initiation factor IF-2PRO_0000137305Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH259.

Structurei

Secondary structure

1
594
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Helixi18 – 3013Combined sources
Beta strandi44 – 485Combined sources
Helixi49 – 557Combined sources
Helixi58 – 625Combined sources
Helixi64 – 674Combined sources
Beta strandi71 – 755Combined sources
Turni79 – 813Combined sources
Helixi83 – 853Combined sources
Beta strandi86 – 883Combined sources
Beta strandi89 – 935Combined sources
Beta strandi95 – 1028Combined sources
Turni103 – 1053Combined sources
Helixi109 – 12012Combined sources
Beta strandi125 – 1306Combined sources
Helixi132 – 1343Combined sources
Helixi146 – 1505Combined sources
Helixi155 – 17420Combined sources
Beta strandi178 – 1814Combined sources
Helixi182 – 1843Combined sources
Turni188 – 1903Combined sources
Beta strandi191 – 1966Combined sources
Turni199 – 2013Combined sources
Helixi205 – 21915Combined sources
Helixi222 – 2243Combined sources
Beta strandi233 – 24210Combined sources
Beta strandi245 – 25915Combined sources
Beta strandi263 – 27614Combined sources
Beta strandi279 – 2835Combined sources
Beta strandi295 – 2984Combined sources
Beta strandi300 – 31112Combined sources
Beta strandi316 – 3183Combined sources
Beta strandi323 – 3264Combined sources
Helixi330 – 34213Combined sources
Beta strandi349 – 3513Combined sources
Beta strandi354 – 3596Combined sources
Helixi360 – 37213Combined sources
Beta strandi378 – 3858Combined sources
Helixi387 – 39711Combined sources
Turni401 – 4033Combined sources
Beta strandi405 – 4106Combined sources
Helixi415 – 4206Combined sources
Beta strandi422 – 43211Combined sources
Helixi434 – 45724Combined sources
Beta strandi464 – 47512Combined sources
Beta strandi477 – 49216Combined sources
Beta strandi496 – 4983Combined sources
Beta strandi504 – 51310Combined sources
Beta strandi516 – 5227Combined sources
Beta strandi527 – 5326Combined sources
Turni537 – 5393Combined sources
Beta strandi545 – 5484Combined sources
Helixi552 – 5565Combined sources
Helixi568 – 58114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G7RX-ray2.20A1-594[»]
1G7SX-ray2.00A1-594[»]
1G7TX-ray2.00A1-594[»]
4V8Zelectron microscopy6.60CV351-586[»]
ProteinModelPortaliO26359.
SMRiO26359. Positions 1-587.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO26359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 220218tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 198G1By similarity
Regioni37 – 415G2By similarity
Regioni76 – 794G3By similarity
Regioni130 – 1334G4By similarity
Regioni198 – 2003G5By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
KOiK03243.
OMAiEVAISIQ.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRSPIVSV LGHVDHGKTT LLDHIRGSAV ASREAGGITQ HIGATEIPMD
60 70 80 90 100
VIEGICGDFL KKFSIRETLP GLFFIDTPGH EAFTTLRKRG GALADLAILI
110 120 130 140 150
VDINEGFKPQ TQEALNILRM YRTPFVVAAN KIDRIHGWRV HEGRPFMETF
160 170 180 190 200
SKQDIQVQQK LDTKVYELVG KLHEEGFESE RFDRVTDFAS QVSIIPISAI
210 220 230 240 250
TGEGIPELLT MLMGLAQQYL REQLKIEEDS PARGTILEVK EETGLGMTID
260 270 280 290 300
AVIYDGILRK DDTIAMMTSK DVISTRIRSL LKPRPLEEMR ESRKKFQKVD
310 320 330 340 350
EVVAAAGIKI VAPGIDDVMA GSPLRVVTDP EKVREEILSE IEDIKIDTDE
360 370 380 390 400
AGVVVKADTL GSLEAVVKIL RDMYVPIKVA DIGDVSRRDV VNAGIALQED
410 420 430 440 450
RVYGAIIAFN VKVIPSAAQE LKNSDIKLFQ GNVIYRLMEE YEEWVRGIEE
460 470 480 490 500
EKKKKWMEAI IKPASIRLIP KLVFRQSKPA IGGVEVLTGV IRQGYPLMND
510 520 530 540 550
DGETVGTVES MQDKGENLKS ASRGQKVAMA IKDAVYGKTI HEGDTLYVDI
560 570 580 590
PENHYHILKE QLSGDLTDEE LDLMDKIAEI KRKKNPDWGM KAPF
Length:594
Mass (Da):66,249
Last modified:January 1, 1998 - v1
Checksum:iB2EDA07718DEBE02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84765.1.
PIRiE69132.
RefSeqiWP_010875898.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84765; AAB84765; MTH_259.
GeneIDi1470220.
KEGGimth:MTH259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84765.1.
PIRiE69132.
RefSeqiWP_010875898.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G7RX-ray2.20A1-594[»]
1G7SX-ray2.00A1-594[»]
1G7TX-ray2.00A1-594[»]
4V8Zelectron microscopy6.60CV351-586[»]
ProteinModelPortaliO26359.
SMRiO26359. Positions 1-587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84765; AAB84765; MTH_259.
GeneIDi1470220.
KEGGimth:MTH259.

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
KOiK03243.
OMAiEVAISIQ.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-259-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO26359.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiIF2P_METTH
AccessioniPrimary (citable) accession number: O26359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.