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Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi130 – 133GTPBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:MTH_259
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373051 – 594Probable translation initiation factor IF-2Add BLAST594

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH259.

Structurei

Secondary structure

1594
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi18 – 30Combined sources13
Beta strandi44 – 48Combined sources5
Helixi49 – 55Combined sources7
Helixi58 – 62Combined sources5
Helixi64 – 67Combined sources4
Beta strandi71 – 75Combined sources5
Turni79 – 81Combined sources3
Helixi83 – 85Combined sources3
Beta strandi86 – 88Combined sources3
Beta strandi89 – 93Combined sources5
Beta strandi95 – 102Combined sources8
Turni103 – 105Combined sources3
Helixi109 – 120Combined sources12
Beta strandi125 – 130Combined sources6
Helixi132 – 134Combined sources3
Helixi146 – 150Combined sources5
Helixi155 – 174Combined sources20
Beta strandi178 – 181Combined sources4
Helixi182 – 184Combined sources3
Turni188 – 190Combined sources3
Beta strandi191 – 196Combined sources6
Turni199 – 201Combined sources3
Helixi205 – 219Combined sources15
Helixi222 – 224Combined sources3
Beta strandi233 – 242Combined sources10
Beta strandi245 – 259Combined sources15
Beta strandi263 – 276Combined sources14
Beta strandi279 – 283Combined sources5
Beta strandi295 – 298Combined sources4
Beta strandi300 – 311Combined sources12
Beta strandi316 – 318Combined sources3
Beta strandi323 – 326Combined sources4
Helixi330 – 342Combined sources13
Beta strandi349 – 351Combined sources3
Beta strandi354 – 359Combined sources6
Helixi360 – 372Combined sources13
Beta strandi378 – 385Combined sources8
Helixi387 – 397Combined sources11
Turni401 – 403Combined sources3
Beta strandi405 – 410Combined sources6
Helixi415 – 420Combined sources6
Beta strandi422 – 432Combined sources11
Helixi434 – 457Combined sources24
Beta strandi464 – 475Combined sources12
Beta strandi477 – 492Combined sources16
Beta strandi496 – 498Combined sources3
Beta strandi504 – 513Combined sources10
Beta strandi516 – 522Combined sources7
Beta strandi527 – 532Combined sources6
Turni537 – 539Combined sources3
Beta strandi545 – 548Combined sources4
Helixi552 – 556Combined sources5
Helixi568 – 581Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G7RX-ray2.20A1-594[»]
1G7SX-ray2.00A1-594[»]
1G7TX-ray2.00A1-594[»]
4V8Zelectron microscopy6.60CV351-586[»]
ProteinModelPortaliO26359.
SMRiO26359.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO26359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 220tr-type GAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 19G1By similarity8
Regioni37 – 41G2By similarity5
Regioni76 – 79G3By similarity4
Regioni130 – 133G4By similarity4
Regioni198 – 200G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
KOiK03243.
OMAiEVAISIQ.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRSPIVSV LGHVDHGKTT LLDHIRGSAV ASREAGGITQ HIGATEIPMD
60 70 80 90 100
VIEGICGDFL KKFSIRETLP GLFFIDTPGH EAFTTLRKRG GALADLAILI
110 120 130 140 150
VDINEGFKPQ TQEALNILRM YRTPFVVAAN KIDRIHGWRV HEGRPFMETF
160 170 180 190 200
SKQDIQVQQK LDTKVYELVG KLHEEGFESE RFDRVTDFAS QVSIIPISAI
210 220 230 240 250
TGEGIPELLT MLMGLAQQYL REQLKIEEDS PARGTILEVK EETGLGMTID
260 270 280 290 300
AVIYDGILRK DDTIAMMTSK DVISTRIRSL LKPRPLEEMR ESRKKFQKVD
310 320 330 340 350
EVVAAAGIKI VAPGIDDVMA GSPLRVVTDP EKVREEILSE IEDIKIDTDE
360 370 380 390 400
AGVVVKADTL GSLEAVVKIL RDMYVPIKVA DIGDVSRRDV VNAGIALQED
410 420 430 440 450
RVYGAIIAFN VKVIPSAAQE LKNSDIKLFQ GNVIYRLMEE YEEWVRGIEE
460 470 480 490 500
EKKKKWMEAI IKPASIRLIP KLVFRQSKPA IGGVEVLTGV IRQGYPLMND
510 520 530 540 550
DGETVGTVES MQDKGENLKS ASRGQKVAMA IKDAVYGKTI HEGDTLYVDI
560 570 580 590
PENHYHILKE QLSGDLTDEE LDLMDKIAEI KRKKNPDWGM KAPF
Length:594
Mass (Da):66,249
Last modified:January 1, 1998 - v1
Checksum:iB2EDA07718DEBE02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84765.1.
PIRiE69132.
RefSeqiWP_010875898.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84765; AAB84765; MTH_259.
GeneIDi1470220.
KEGGimth:MTH_259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84765.1.
PIRiE69132.
RefSeqiWP_010875898.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G7RX-ray2.20A1-594[»]
1G7SX-ray2.00A1-594[»]
1G7TX-ray2.00A1-594[»]
4V8Zelectron microscopy6.60CV351-586[»]
ProteinModelPortaliO26359.
SMRiO26359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84765; AAB84765; MTH_259.
GeneIDi1470220.
KEGGimth:MTH_259.

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
KOiK03243.
OMAiEVAISIQ.

Miscellaneous databases

EvolutionaryTraceiO26359.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2P_METTH
AccessioniPrimary (citable) accession number: O26359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.