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O26352

- SYW_METTH

UniProt

O26352 - SYW_METTH

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-251-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:MTH_251
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Tryptophan--tRNA ligasePRO_0000136726Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH251.

    Structurei

    3D structure databases

    ProteinModelPortaliO26352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi70 – 789"HIGH" region
    Motifi251 – 2555"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiKTFIFNN.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O26352-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDPWGSAKL EYQDLIENFG VRPFSEVLDE VPEPSWLMRR GIIFGHRDYE    50
    RIISAMKKGE DFAVVTGMMP SGRMHIGHKM IVDQLRWYDR MGAEIFIPIA 100
    DMEAYSARGV DFEDSRRIAI EEYIAGYIAL GLDLEKDNIH VYLQSENLMV 150
    EDLAYVLAGK VNFNELRAIY GFTGSTSMAH MYAPIIQVSD ILHPQLDELG 200
    GPRPVIVPVG PDQDPHIRLT RDIAARFRDR YGFILPSSTY HRFMGGLTGG 250
    KMSSNRPKSA IFLSDTPEEA EAKIRNAKTG GRETLKEQRE LGGVPEECII 300
    YETLLYHMSG SDSRLEEIYE SCRNGTLMCG ECKNNTAEFI RKFFEELSVK 350
    REKALPAARR ILEG 364
    Length:364
    Mass (Da):41,301
    Last modified:January 1, 1998 - v1
    Checksum:iC2F348903338F61D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84757.1.
    PIRiE69131.
    RefSeqiNP_275394.1. NC_000916.1.
    WP_010875890.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB84757; AAB84757; MTH_251.
    GeneIDi1470212.
    KEGGimth:MTH251.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84757.1 .
    PIRi E69131.
    RefSeqi NP_275394.1. NC_000916.1.
    WP_010875890.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O26352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB84757 ; AAB84757 ; MTH_251 .
    GeneIDi 1470212.
    KEGGi mth:MTH251.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi KTFIFNN.

    Enzyme and pathway databases

    BioCyci MTHE187420:GJNM-251-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiSYW_METTH
    AccessioniPrimary (citable) accession number: O26352
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3