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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-232-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MTH_251
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367261 – 364Tryptophan--tRNA ligaseAdd BLAST364

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH251

Structurei

3D structure databases

ProteinModelPortaliO26352
SMRiO26352
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi70 – 78"HIGH" region9
Motifi251 – 255"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

O26352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDPWGSAKL EYQDLIENFG VRPFSEVLDE VPEPSWLMRR GIIFGHRDYE
60 70 80 90 100
RIISAMKKGE DFAVVTGMMP SGRMHIGHKM IVDQLRWYDR MGAEIFIPIA
110 120 130 140 150
DMEAYSARGV DFEDSRRIAI EEYIAGYIAL GLDLEKDNIH VYLQSENLMV
160 170 180 190 200
EDLAYVLAGK VNFNELRAIY GFTGSTSMAH MYAPIIQVSD ILHPQLDELG
210 220 230 240 250
GPRPVIVPVG PDQDPHIRLT RDIAARFRDR YGFILPSSTY HRFMGGLTGG
260 270 280 290 300
KMSSNRPKSA IFLSDTPEEA EAKIRNAKTG GRETLKEQRE LGGVPEECII
310 320 330 340 350
YETLLYHMSG SDSRLEEIYE SCRNGTLMCG ECKNNTAEFI RKFFEELSVK
360
REKALPAARR ILEG
Length:364
Mass (Da):41,301
Last modified:January 1, 1998 - v1
Checksum:iC2F348903338F61D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB84757.1
PIRiE69131
RefSeqiWP_010875890.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB84757; AAB84757; MTH_251
GeneIDi1470212
KEGGimth:MTH_251
PATRICifig|187420.15.peg.220

Similar proteinsi

Entry informationi

Entry nameiSYW_METTH
AccessioniPrimary (citable) accession number: O26352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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