Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O26352

- SYW_METTH

UniProt

O26352 - SYW_METTH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MTH_251
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Tryptophan--tRNA ligasePRO_0000136726Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH251.

Structurei

3D structure databases

ProteinModelPortaliO26352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 789"HIGH" region
Motifi251 – 2555"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiKTFIFNN.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

O26352-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDPWGSAKL EYQDLIENFG VRPFSEVLDE VPEPSWLMRR GIIFGHRDYE
60 70 80 90 100
RIISAMKKGE DFAVVTGMMP SGRMHIGHKM IVDQLRWYDR MGAEIFIPIA
110 120 130 140 150
DMEAYSARGV DFEDSRRIAI EEYIAGYIAL GLDLEKDNIH VYLQSENLMV
160 170 180 190 200
EDLAYVLAGK VNFNELRAIY GFTGSTSMAH MYAPIIQVSD ILHPQLDELG
210 220 230 240 250
GPRPVIVPVG PDQDPHIRLT RDIAARFRDR YGFILPSSTY HRFMGGLTGG
260 270 280 290 300
KMSSNRPKSA IFLSDTPEEA EAKIRNAKTG GRETLKEQRE LGGVPEECII
310 320 330 340 350
YETLLYHMSG SDSRLEEIYE SCRNGTLMCG ECKNNTAEFI RKFFEELSVK
360
REKALPAARR ILEG
Length:364
Mass (Da):41,301
Last modified:January 1, 1998 - v1
Checksum:iC2F348903338F61D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84757.1.
PIRiE69131.
RefSeqiNP_275394.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84757; AAB84757; MTH_251.
GeneIDi1470212.
KEGGimth:MTH251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84757.1 .
PIRi E69131.
RefSeqi NP_275394.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84757 ; AAB84757 ; MTH_251 .
GeneIDi 1470212.
KEGGi mth:MTH251.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi KTFIFNN.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-251-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiSYW_METTH
AccessioniPrimary (citable) accession number: O26352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3