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O26352

- SYW_METTH

UniProt

O26352 - SYW_METTH

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Protein

Tryptophan--tRNA ligase

Gene
trpS, MTH_251
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:MTH_251
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Tryptophan--tRNA ligaseUniRule annotationPRO_0000136726Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH251.

Structurei

3D structure databases

ProteinModelPortaliO26352.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 789"HIGH" regionUniRule annotation
Motifi251 – 2555"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiKTFIFNN.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

O26352-1 [UniParc]FASTAAdd to Basket

« Hide

MIDPWGSAKL EYQDLIENFG VRPFSEVLDE VPEPSWLMRR GIIFGHRDYE    50
RIISAMKKGE DFAVVTGMMP SGRMHIGHKM IVDQLRWYDR MGAEIFIPIA 100
DMEAYSARGV DFEDSRRIAI EEYIAGYIAL GLDLEKDNIH VYLQSENLMV 150
EDLAYVLAGK VNFNELRAIY GFTGSTSMAH MYAPIIQVSD ILHPQLDELG 200
GPRPVIVPVG PDQDPHIRLT RDIAARFRDR YGFILPSSTY HRFMGGLTGG 250
KMSSNRPKSA IFLSDTPEEA EAKIRNAKTG GRETLKEQRE LGGVPEECII 300
YETLLYHMSG SDSRLEEIYE SCRNGTLMCG ECKNNTAEFI RKFFEELSVK 350
REKALPAARR ILEG 364
Length:364
Mass (Da):41,301
Last modified:January 1, 1998 - v1
Checksum:iC2F348903338F61D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84757.1.
PIRiE69131.
RefSeqiNP_275394.1. NC_000916.1.
WP_010875890.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84757; AAB84757; MTH_251.
GeneIDi1470212.
KEGGimth:MTH251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84757.1 .
PIRi E69131.
RefSeqi NP_275394.1. NC_000916.1.
WP_010875890.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84757 ; AAB84757 ; MTH_251 .
GeneIDi 1470212.
KEGGi mth:MTH251.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi KTFIFNN.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-251-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiSYW_METTH
AccessioniPrimary (citable) accession number: O26352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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