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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331UniRule annotation
Metal bindingi33 – 331MagnesiumUniRule annotation
Binding sitei51 – 511SubstrateUniRule annotation
Active sitei82 – 821Proton acceptorUniRule annotation
Binding sitei83 – 831SubstrateUniRule annotation
Binding sitei85 – 851SubstrateUniRule annotation
Binding sitei204 – 2041SubstrateUniRule annotation
Metal bindingi223 – 2231MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-232-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:MTH_232
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)PRO_0000123734Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi187420.MTH232.

Structurei

3D structure databases

ProteinModelPortaliO26334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 374Substrate bindingUniRule annotation
Regioni79 – 813Substrate bindingUniRule annotation
Regioni210 – 2123Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
KOiK15888.
OMAiWAKLKNK.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLKPLYKL YEWYISRNLR RDRMPRHVAI IMDGNRRYSK LQGSMNPIEG
60 70 80 90 100
HKKGIETLEK VLDWCVDLGI EIVTAYAFST ENFKRPEKEV KGLMKLFREN
110 120 130 140 150
FEAIASNEKI HKNRVRVRAV GKLELLPEDV RRAIEIAEKS TEQYSDRLVN
160 170 180 190 200
IAIGYDGRQE IVDATRKIAE DVKAGLIDPE DIDEDMINRN LYTAGLEDPH
210 220 230 240 250
LIIRTSGEER LSGFLLWQSS YSELYFCDSL WPELRKVDFL RAIRSYQQRE

RRFGV
Length:255
Mass (Da):29,900
Last modified:January 1, 1998 - v1
Checksum:i370C6D8F85FFB8D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84738.1.
PIRiH69128.
RefSeqiWP_010875871.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84738; AAB84738; MTH_232.
GeneIDi1470193.
KEGGimth:MTH_232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84738.1.
PIRiH69128.
RefSeqiWP_010875871.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO26334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84738; AAB84738; MTH_232.
GeneIDi1470193.
KEGGimth:MTH_232.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
KOiK15888.
OMAiWAKLKNK.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-232-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiUPPS_METTH
AccessioniPrimary (citable) accession number: O26334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.