O26329 (CBIC_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cobalt-precorrin-8X methylmutase
EC=5.4.1.-

Alternative name(s):
Cobalt-precorrin isomerase
HBA synthase

Gene names

Name:	cbiC
Synonyms:	cobH
Ordered Locus Names:	MTH_227

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid By similarity.
Catalytic activity	Cobalt-precorrin-8X = cobyrinate.
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 9/10.
Sequence similarities	Belongs to the CobH family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	precorrin-8X methylmutase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Cobalt-precorrin-8X methylmutase		PRO_0000135929
Sites
	Active site	44	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O26329 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: DC45675682D12FF6	FASTA	206	21,904
	10 20 30 40 50 60 MMGASTGQGY EIARKSREIV RELISEDISS LGPAEVAIVE RIVHSTADPE YARITEFSQG 70 80 90 100 110 120 FVDEALRSLR SSGGILTDIE MVRAGISHPS RCYIREPAVR ELAEKRDITR AAASMEYAAS 130 140 150 160 170 180 QGFRGIVVIG NAPTALMKVI ELTLEGLMDA RAVIGVPVGF VGAAESKEAL RGTEIPHMIT 190 200 RGPKGGTPVA VAAANALIAL SKDKEV

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB84733.1.
PIR	B69128.
RefSeq	NP_275370.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26329.
ModBase	Search...
Protein-protein interaction databases
STRING	O26329.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470188.
GenomeReviews	Gene locus MTH_227 in contig AE000666_GR.
KEGG	mth:MTH227.
NMPDR	fig|187420.1.peg.225.
Phylogenomic databases
eggNOG	arNOG05874.
HOGENOM	HBG553498.
OMA	ACGMVDL.
ProtClustDB	PRK06264.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH227-MONOMER.
Family and domain databases
InterPro	IPR003722. Cbl_synth_CobH/CbiC_core. [Graphical view]
Gene3D	G3DSA:3.40.50.10230. Cbl_synth_CobH/CbiC_core. 1 hit.
KO	K06042.
Pfam	PF02570. CbiC. 1 hit. [Graphical view]
SUPFAM	SSF63965. CbiC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CBIC_METTH

Accession

Primary (citable) accession number: O26329

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program