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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathway: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251NADBy similarity
Binding sitei187 – 1871NADBy similarity
Binding sitei210 – 2101NADBy similarity
Binding sitei233 – 2331SubstrateBy similarity
Metal bindingi255 – 2551ZincBy similarity
Binding sitei255 – 2551SubstrateBy similarity
Metal bindingi258 – 2581ZincBy similarity
Binding sitei258 – 2581SubstrateBy similarity
Active sitei323 – 3231Proton acceptorBy similarity
Active sitei324 – 3241Proton acceptorBy similarity
Binding sitei324 – 3241SubstrateBy similarity
Metal bindingi357 – 3571ZincBy similarity
Binding sitei357 – 3571SubstrateBy similarity
Binding sitei411 – 4111SubstrateBy similarity
Metal bindingi416 – 4161ZincBy similarity
Binding sitei416 – 4161SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-225-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MTH_225
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Histidinol dehydrogenasePRO_0000135899Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH225.

Structurei

3D structure databases

ProteinModelPortaliO26327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiLSVQSFL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMKITEFDY RRISELVERA RLDVDDVLGP VADIISMVRD GGDDALRELT
60 70 80 90 100
GRFDGVTVEN FRVSREEIEE AHKNLEPGVK EALREAASNI EEFHRMQMPS
110 120 130 140 150
GWMSEVRPGV MAGQLVRPID SVGCYIPGGR AVYPSTILMT VIPARIAGVE
160 170 180 190 200
RIVCCTPPAQ DGSVPDAVLV AADMAGASEI YRVGGAQAVA AMAYGTETIR
210 220 230 240 250
PVDKIVGPGN IFVTAAKKLV YGEVDIDFPA GPSEVLIIAD ETASPEYIAL
260 270 280 290 300
EILAQAEHDP QAASVLVTDS RDLALEVKEM VHENIKYMER ANIIRESLER
310 320 330 340 350
YGMIVLTADI DEAVDFSNAY APEHLVIMTD SPEETLEGIR NAGSIFLGEL
360 370 380 390 400
SPVAAGDYGS GTNHVLPTSG CARMYSGLST ESFIKKPTVQ RITKEGLRNL
410 420
QGTVLKLAEY EGLHAHAESF RRRLRD
Length:426
Mass (Da):46,420
Last modified:January 1, 1998 - v1
Checksum:iA9A0F2AA25B8594A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84731.1.
PIRiH69127.
RefSeqiNP_275368.1. NC_000916.1.
WP_010875864.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84731; AAB84731; MTH_225.
GeneIDi1470186.
KEGGimth:MTH225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84731.1.
PIRiH69127.
RefSeqiNP_275368.1. NC_000916.1.
WP_010875864.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO26327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84731; AAB84731; MTH_225.
GeneIDi1470186.
KEGGimth:MTH225.

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiLSVQSFL.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciMTHE187420:GJNM-225-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiHISX_METTH
AccessioniPrimary (citable) accession number: O26327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.