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O26327

- HISX_METTH

UniProt

O26327 - HISX_METTH

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251NADBy similarity
Binding sitei187 – 1871NADBy similarity
Binding sitei210 – 2101NADBy similarity
Binding sitei233 – 2331SubstrateBy similarity
Metal bindingi255 – 2551ZincBy similarity
Binding sitei255 – 2551SubstrateBy similarity
Metal bindingi258 – 2581ZincBy similarity
Binding sitei258 – 2581SubstrateBy similarity
Active sitei323 – 3231Proton acceptorBy similarity
Active sitei324 – 3241Proton acceptorBy similarity
Binding sitei324 – 3241SubstrateBy similarity
Metal bindingi357 – 3571ZincBy similarity
Binding sitei357 – 3571SubstrateBy similarity
Binding sitei411 – 4111SubstrateBy similarity
Metal bindingi416 – 4161ZincBy similarity
Binding sitei416 – 4161SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-225-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MTH_225
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Histidinol dehydrogenasePRO_0000135899Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH225.

Structurei

3D structure databases

ProteinModelPortaliO26327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26327-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLMKITEFDY RRISELVERA RLDVDDVLGP VADIISMVRD GGDDALRELT
60 70 80 90 100
GRFDGVTVEN FRVSREEIEE AHKNLEPGVK EALREAASNI EEFHRMQMPS
110 120 130 140 150
GWMSEVRPGV MAGQLVRPID SVGCYIPGGR AVYPSTILMT VIPARIAGVE
160 170 180 190 200
RIVCCTPPAQ DGSVPDAVLV AADMAGASEI YRVGGAQAVA AMAYGTETIR
210 220 230 240 250
PVDKIVGPGN IFVTAAKKLV YGEVDIDFPA GPSEVLIIAD ETASPEYIAL
260 270 280 290 300
EILAQAEHDP QAASVLVTDS RDLALEVKEM VHENIKYMER ANIIRESLER
310 320 330 340 350
YGMIVLTADI DEAVDFSNAY APEHLVIMTD SPEETLEGIR NAGSIFLGEL
360 370 380 390 400
SPVAAGDYGS GTNHVLPTSG CARMYSGLST ESFIKKPTVQ RITKEGLRNL
410 420
QGTVLKLAEY EGLHAHAESF RRRLRD
Length:426
Mass (Da):46,420
Last modified:January 1, 1998 - v1
Checksum:iA9A0F2AA25B8594A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84731.1.
PIRiH69127.
RefSeqiNP_275368.1. NC_000916.1.
WP_010875864.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84731; AAB84731; MTH_225.
GeneIDi1470186.
KEGGimth:MTH225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84731.1 .
PIRi H69127.
RefSeqi NP_275368.1. NC_000916.1.
WP_010875864.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84731 ; AAB84731 ; MTH_225 .
GeneIDi 1470186.
KEGGi mth:MTH225.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MTHE187420:GJNM-225-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiHISX_METTH
AccessioniPrimary (citable) accession number: O26327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3