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O26327

- HISX_METTH

UniProt

O26327 - HISX_METTH

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei125 – 1251NADBy similarity
    Binding sitei187 – 1871NADBy similarity
    Binding sitei210 – 2101NADBy similarity
    Binding sitei233 – 2331SubstrateBy similarity
    Metal bindingi255 – 2551ZincBy similarity
    Binding sitei255 – 2551SubstrateBy similarity
    Metal bindingi258 – 2581ZincBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Active sitei323 – 3231Proton acceptorBy similarity
    Active sitei324 – 3241Proton acceptorBy similarity
    Binding sitei324 – 3241SubstrateBy similarity
    Metal bindingi357 – 3571ZincBy similarity
    Binding sitei357 – 3571SubstrateBy similarity
    Binding sitei411 – 4111SubstrateBy similarity
    Metal bindingi416 – 4161ZincBy similarity
    Binding sitei416 – 4161SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-225-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:MTH_225
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Histidinol dehydrogenasePRO_0000135899Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH225.

    Structurei

    3D structure databases

    ProteinModelPortaliO26327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiYAAKLCG.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O26327-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMKITEFDY RRISELVERA RLDVDDVLGP VADIISMVRD GGDDALRELT    50
    GRFDGVTVEN FRVSREEIEE AHKNLEPGVK EALREAASNI EEFHRMQMPS 100
    GWMSEVRPGV MAGQLVRPID SVGCYIPGGR AVYPSTILMT VIPARIAGVE 150
    RIVCCTPPAQ DGSVPDAVLV AADMAGASEI YRVGGAQAVA AMAYGTETIR 200
    PVDKIVGPGN IFVTAAKKLV YGEVDIDFPA GPSEVLIIAD ETASPEYIAL 250
    EILAQAEHDP QAASVLVTDS RDLALEVKEM VHENIKYMER ANIIRESLER 300
    YGMIVLTADI DEAVDFSNAY APEHLVIMTD SPEETLEGIR NAGSIFLGEL 350
    SPVAAGDYGS GTNHVLPTSG CARMYSGLST ESFIKKPTVQ RITKEGLRNL 400
    QGTVLKLAEY EGLHAHAESF RRRLRD 426
    Length:426
    Mass (Da):46,420
    Last modified:January 1, 1998 - v1
    Checksum:iA9A0F2AA25B8594A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84731.1.
    PIRiH69127.
    RefSeqiNP_275368.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB84731; AAB84731; MTH_225.
    GeneIDi1470186.
    KEGGimth:MTH225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84731.1 .
    PIRi H69127.
    RefSeqi NP_275368.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O26327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB84731 ; AAB84731 ; MTH_225 .
    GeneIDi 1470186.
    KEGGi mth:MTH225.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi YAAKLCG.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci MTHE187420:GJNM-225-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiHISX_METTH
    AccessioniPrimary (citable) accession number: O26327
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3