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Protein

Thermosome subunit alpha

Gene

thsA

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit alpha
Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1
Gene namesi
Name:thsA
Ordered Locus Names:MTH_218
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283931 – 542Thermosome subunit alphaAdd BLAST542

Proteomic databases

PRIDEiO26320.

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi187420.MTH218.

Structurei

3D structure databases

ProteinModelPortaliO26320.
SMRiO26320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
OMAiQEHLVVP.
OrthoDBiPOG093Z02BT.

Family and domain databases

CDDicd03343. cpn60. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
IPR012714. Thermosome_arc.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 2 hits.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequencei

Sequence statusi: Complete.

O26320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGQQPIFI LPQDTSRYVG REAQRINILA GKVLAETVRT TLGPKGMDKM
60 70 80 90 100
LVDSLGDIVI TNDGVTILRE MDISHPAAKM LVEVAKTQED EVGDGTTTAV
110 120 130 140 150
IIAGELLKEA EKLIEMGVHP TIIALGYRNA ALKAQEILEE ISMEASDRDT
160 170 180 190 200
LMKVAITAMT GKGSERAKEK LAELVVDAVM QVEEDGEIDK DNINIQRIQG
210 220 230 240 250
ASVNESRIVN GIVIDKSRAD TSMPKRIEKA RIALLKYPIE VKDLETDAKI
260 270 280 290 300
RLTDPSQMQA FIEQEEQMIR DMVEKIKSSG ANVVFCQKGI DDLALHYLSR
310 320 330 340 350
EGIMALKRVK KSDIKRIEKA TGARLVTNID DLTAEDLGEA GVIYEKKIFD
360 370 380 390 400
EVLTFIEECR DPKAISIILR GSTKHVAEEM ERALEDAIGV VASTLEDREV
410 420 430 440 450
VAGGGAPEVE IARKLREYAD TISGREQLAV SAFADALEIV PKTLAENAGL
460 470 480 490 500
DSIDVLVDLR AAHEESPYMG IDVFDGNIVD MKEAGVIEPQ RVKKQAIQSA
510 520 530 540
AEAAEMILRI DDMIAARGFD VSSKDEEDME GMGGMGGMPP MM
Length:542
Mass (Da):59,263
Last modified:July 15, 1998 - v2
Checksum:iF0F9876585DFA9AE
GO

Sequence cautioni

The sequence AAB84724 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84724.1. Different initiation.
PIRiH69126.
RefSeqiWP_048060772.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84724; AAB84724; MTH_218.
GeneIDi1470179.
KEGGimth:MTH_218.
PATRICifig|187420.15.peg.187.

Similar proteinsi

Entry informationi

Entry nameiTHSA_METTH
AccessioniPrimary (citable) accession number: O26320
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 22, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families