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Protein

Thermosome subunit alpha

Gene

thsA

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-199-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit alpha
Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1
Gene namesi
Name:thsA
Ordered Locus Names:MTH_218
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283931 – 542Thermosome subunit alphaAdd BLAST542

Proteomic databases

PRIDEiO26320

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi187420.MTH218

Structurei

3D structure databases

ProteinModelPortaliO26320
SMRiO26320
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiarCOG01257 Archaea
COG0459 LUCA
KOiK22447
OMAiIMRIDTL
OrthoDBiPOG093Z02BT

Family and domain databases

CDDicd03343 cpn60, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
IPR012714 Thermosome_arc
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02339 thermosome_arch, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

O26320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGQQPIFI LPQDTSRYVG REAQRINILA GKVLAETVRT TLGPKGMDKM
60 70 80 90 100
LVDSLGDIVI TNDGVTILRE MDISHPAAKM LVEVAKTQED EVGDGTTTAV
110 120 130 140 150
IIAGELLKEA EKLIEMGVHP TIIALGYRNA ALKAQEILEE ISMEASDRDT
160 170 180 190 200
LMKVAITAMT GKGSERAKEK LAELVVDAVM QVEEDGEIDK DNINIQRIQG
210 220 230 240 250
ASVNESRIVN GIVIDKSRAD TSMPKRIEKA RIALLKYPIE VKDLETDAKI
260 270 280 290 300
RLTDPSQMQA FIEQEEQMIR DMVEKIKSSG ANVVFCQKGI DDLALHYLSR
310 320 330 340 350
EGIMALKRVK KSDIKRIEKA TGARLVTNID DLTAEDLGEA GVIYEKKIFD
360 370 380 390 400
EVLTFIEECR DPKAISIILR GSTKHVAEEM ERALEDAIGV VASTLEDREV
410 420 430 440 450
VAGGGAPEVE IARKLREYAD TISGREQLAV SAFADALEIV PKTLAENAGL
460 470 480 490 500
DSIDVLVDLR AAHEESPYMG IDVFDGNIVD MKEAGVIEPQ RVKKQAIQSA
510 520 530 540
AEAAEMILRI DDMIAARGFD VSSKDEEDME GMGGMGGMPP MM
Length:542
Mass (Da):59,263
Last modified:July 15, 1998 - v2
Checksum:iF0F9876585DFA9AE
GO

Sequence cautioni

The sequence AAB84724 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB84724.1 Different initiation.
PIRiH69126
RefSeqiWP_048060772.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB84724; AAB84724; MTH_218
GeneIDi1470179
KEGGimth:MTH_218
PATRICifig|187420.15.peg.187

Similar proteinsi

Entry informationi

Entry nameiTHSA_METTH
AccessioniPrimary (citable) accession number: O26320
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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