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O26273

- GLMS_METTH

UniProt

O26273 - GLMS_METTH

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, MTH_171
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei585 – 5851For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-171-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:MTH_171
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 590589Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135427Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi187420.MTH171.

Structurei

3D structure databases

ProteinModelPortaliO26273.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2Add
BLAST
Domaini277 – 415139SIS 1Add
BLAST
Domaini438 – 580143SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiPVTRRFM.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O26273-1 [UniParc]FASTAAdd to Basket

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MCGIVACILK DGSAAPVLLE CVRRLEYRGY DSVGIATSDP MIRIKKDSGK    50
IDEVDAELDL ADLPGTMGIA HVRWATHGLP TAENAHPHTD CSGEIAVVHN 100
GIIENYLEVK EELESEGHIF RSETDTEVIP HLIEKYMDEG MDLEAATATA 150
LRKLRGAYAI AAVSSREPGR IVGARKESPL IVGVGEGEYF LASDVPAILN 200
HTSRVIYLDD GEMVILDGDL RVTDMEGNTV EKEVHSIDWS ADMAEKGGYD 250
HFMLKEIHEE PSAVRDTLTE WDEVLGVVEE IGEVERICFV ACGTSYHASL 300
VGKYLFESLL GIPTDVILAS EFRYSAGALN DRTLAIFISQ SGETADTLNA 350
LRAANSRAKT LAIVNVLGSS ATREAQHVLY TRAGPEIGVA ATKTYVSQLT 400
VIYMLVAAMG APELMDRLER VPEFMERALE DEDGIKELAA TCSDVSDFFF 450
IGRGFAYPTA LEGALKLKEI TYIHGEGYAA GELKHGPLAL IDNGVPVVAI 500
SPPGPCHDKT LSNVEEVRAR GARVIGVGSI SDESLRKEAD DFIGLDPEVD 550
DVISPLVYIV PLQLLSYHVS VERGLDPDKP KNLAKCVTVE 590
Length:590
Mass (Da):63,995
Last modified:January 23, 2007 - v3
Checksum:i7CE10DAB33103FE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84677.1.
PIRiG69095.
RefSeqiNP_275314.1. NC_000916.1.
WP_010875810.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84677; AAB84677; MTH_171.
GeneIDi1470132.
KEGGimth:MTH171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84677.1 .
PIRi G69095.
RefSeqi NP_275314.1. NC_000916.1.
WP_010875810.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH171.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84677 ; AAB84677 ; MTH_171 .
GeneIDi 1470132.
KEGGi mth:MTH171.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi PVTRRFM.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-171-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiGLMS_METTH
AccessioniPrimary (citable) accession number: O26273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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