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O26268

- HEM4_METTH

UniProt

O26268 - HEM4_METTH

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Protein

Putative uroporphyrinogen-III synthase

Gene

hemD

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-166-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:MTH_166
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Putative uroporphyrinogen-III synthasePRO_0000135250Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH166.

Structurei

3D structure databases

ProteinModelPortaliO26268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
KOiK01719.
OMAiWDLVIFT.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

O26268-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVTRPPERS AEAVELIEGA GGRALVAPTL ELKEAHTESL REVCRRADEW
60 70 80 90 100
DLVIFTSQAA VESLFQLCRE FAGKIRKDCL VAVIGPRTAR VAGEHGLRVD
110 120 130 140 150
IVPEDYTAEG LLDALTGLNI EGWKVALPRT LSARKVLPRG LEMMGAEVLV
160 170 180 190 200
AEAYRSGLPE DTGPAEELID GLLDGKVDAV TFTSPLTVEN LFKIAGNRRK
210 220 230 240 250
ELIEVLKRVK VAAIGPITLR KLEEHGITAV TPERYTVKDM IAALAVSMGE

DVD
Length:253
Mass (Da):27,462
Last modified:January 1, 1998 - v1
Checksum:iD3B0A791369A4F3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84672.1.
PIRiH69088.
RefSeqiNP_275309.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84672; AAB84672; MTH_166.
GeneIDi1470127.
KEGGimth:MTH166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84672.1 .
PIRi H69088.
RefSeqi NP_275309.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH166.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84672 ; AAB84672 ; MTH_166 .
GeneIDi 1470127.
KEGGi mth:MTH166.

Phylogenomic databases

eggNOGi COG1587.
KOi K01719.
OMAi WDLVIFT.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BioCyci MTHE187420:GJNM-166-MONOMER.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiHEM4_METTH
AccessioniPrimary (citable) accession number: O26268
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3