O26268 (HEM4_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uroporphyrinogen-III synthase
Short name=UROS
EC=4.2.1.75

Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase

Gene names

Name:	hemD
Ordered Locus Names:	MTH_166

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.
Catalytic activity	Hydroxymethylbilane = uroporphyrinogen III + H2O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
Sequence similarities	Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Putative uroporphyrinogen-III synthase		PRO_0000135250

Sequences

	Sequence		Length	Mass (Da)
	O26268 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: D3B0A791369A4F3E	FASTA	253	27,462
	10 20 30 40 50 60 MAVTRPPERS AEAVELIEGA GGRALVAPTL ELKEAHTESL REVCRRADEW DLVIFTSQAA 70 80 90 100 110 120 VESLFQLCRE FAGKIRKDCL VAVIGPRTAR VAGEHGLRVD IVPEDYTAEG LLDALTGLNI 130 140 150 160 170 180 EGWKVALPRT LSARKVLPRG LEMMGAEVLV AEAYRSGLPE DTGPAEELID GLLDGKVDAV 190 200 210 220 230 240 TFTSPLTVEN LFKIAGNRRK ELIEVLKRVK VAAIGPITLR KLEEHGITAV TPERYTVKDM 250 IAALAVSMGE DVD

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB84672.1.
PIR	H69088.
RefSeq	NP_275309.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26268.
ModBase	Search...
Protein-protein interaction databases
STRING	O26268.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470127.
GenomeReviews	Gene locus MTH_166 in contig AE000666_GR.
KEGG	mth:MTH166.
NMPDR	fig|187420.1.peg.164.
Phylogenomic databases
eggNOG	arNOG08063.
HOGENOM	HBG541220.
OMA	SIGPITK.
ProtClustDB	CLSK797845.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH166-MONOMER.
Family and domain databases
InterPro	IPR003754. 4pyrrol_synth_uPrphyn_synth. [Graphical view]
KO	K01719.
Pfam	PF02602. HEM4. 1 hit. [Graphical view]
SUPFAM	SSF69618. HEM4_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEM4_METTH

Accession

Primary (citable) accession number: O26268

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program