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O26268

- HEM4_METTH

UniProt

O26268 - HEM4_METTH

Protein

Putative uroporphyrinogen-III synthase

Gene

hemD

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-166-MONOMER.
    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative uroporphyrinogen-III synthase (EC:4.2.1.75)
    Short name:
    UROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:hemD
    Ordered Locus Names:MTH_166
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Putative uroporphyrinogen-III synthasePRO_0000135250Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH166.

    Structurei

    3D structure databases

    ProteinModelPortaliO26268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1587.
    KOiK01719.
    OMAiWDLVIFT.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O26268-1 [UniParc]FASTAAdd to Basket

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    MAVTRPPERS AEAVELIEGA GGRALVAPTL ELKEAHTESL REVCRRADEW    50
    DLVIFTSQAA VESLFQLCRE FAGKIRKDCL VAVIGPRTAR VAGEHGLRVD 100
    IVPEDYTAEG LLDALTGLNI EGWKVALPRT LSARKVLPRG LEMMGAEVLV 150
    AEAYRSGLPE DTGPAEELID GLLDGKVDAV TFTSPLTVEN LFKIAGNRRK 200
    ELIEVLKRVK VAAIGPITLR KLEEHGITAV TPERYTVKDM IAALAVSMGE 250
    DVD 253
    Length:253
    Mass (Da):27,462
    Last modified:January 1, 1998 - v1
    Checksum:iD3B0A791369A4F3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84672.1.
    PIRiH69088.
    RefSeqiNP_275309.1. NC_000916.1.
    WP_010875805.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB84672; AAB84672; MTH_166.
    GeneIDi1470127.
    KEGGimth:MTH166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84672.1 .
    PIRi H69088.
    RefSeqi NP_275309.1. NC_000916.1.
    WP_010875805.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O26268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH166.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB84672 ; AAB84672 ; MTH_166 .
    GeneIDi 1470127.
    KEGGi mth:MTH166.

    Phylogenomic databases

    eggNOGi COG1587.
    KOi K01719.
    OMAi WDLVIFT.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .
    BioCyci MTHE187420:GJNM-166-MONOMER.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiHEM4_METTH
    AccessioniPrimary (citable) accession number: O26268
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3