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Protein

Putative uroporphyrinogen-III synthase

Gene

hemD

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (hemB)
  2. Probable porphobilinogen deaminase (hemC)
  3. Putative uroporphyrinogen-III synthase (hemD)
  4. no protein annotated in this organism
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:MTH_166
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352501 – 253Putative uroporphyrinogen-III synthaseAdd BLAST253

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH166.

Structurei

3D structure databases

ProteinModelPortaliO26268.
SMRiO26268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG02048. Archaea.
COG1587. LUCA.
KOiK01719.
OMAiVWAVGKT.
OrthoDBiPOG093Z0AQY.

Family and domain databases

CDDicd06578. HemD. 1 hit.
InterProiView protein in InterPro
IPR036108. 4pyrrol_syn_uPrphyn_synt_sf.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
PfamiView protein in Pfam
PF02602. HEM4. 1 hit.
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

O26268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTRPPERS AEAVELIEGA GGRALVAPTL ELKEAHTESL REVCRRADEW
60 70 80 90 100
DLVIFTSQAA VESLFQLCRE FAGKIRKDCL VAVIGPRTAR VAGEHGLRVD
110 120 130 140 150
IVPEDYTAEG LLDALTGLNI EGWKVALPRT LSARKVLPRG LEMMGAEVLV
160 170 180 190 200
AEAYRSGLPE DTGPAEELID GLLDGKVDAV TFTSPLTVEN LFKIAGNRRK
210 220 230 240 250
ELIEVLKRVK VAAIGPITLR KLEEHGITAV TPERYTVKDM IAALAVSMGE

DVD
Length:253
Mass (Da):27,462
Last modified:January 1, 1998 - v1
Checksum:iD3B0A791369A4F3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84672.1.
PIRiH69088.

Genome annotation databases

EnsemblBacteriaiAAB84672; AAB84672; MTH_166.
KEGGimth:MTH_166.
PATRICifig|187420.15.peg.139.

Similar proteinsi

Entry informationi

Entry nameiHEM4_METTH
AccessioniPrimary (citable) accession number: O26268
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families