O26255 (P152_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MTH_152

Gene names

Ordered Locus Names:

MTH_152

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	FMN.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the flavoredoxin family.

Ontologies

Keywords
Ligand	FMN Flavoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro flavin reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 186

186

Protein MTH_152

PRO_0000085528

Secondary structure

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186

Helix Strand Turn

Details...

Turn

3 – 5

3

Beta strand

6 – 9

4

Helix

11 – 16

6

Beta strand

24 – 29

6

Beta strand

35 – 40

6

Beta strand

42 – 47

6

Turn

48 – 51

4

Beta strand

52 – 57

6

Helix

62 – 70

9

Beta strand

72 – 77

6

Helix

80 – 82

3

Helix

83 – 88

6

Helix

99 – 103

5

Beta strand

111 – 115

5

Beta strand

122 – 135

14

Beta strand

138 – 151

14

Helix

162 – 165

4

Beta strand

167 – 172

6

Beta strand

175 – 178

4

Beta strand

182 – 184

3

Sequences

	Sequence		Length	Mass (Da)
	O26255 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 6997E8C6D9234A89	FASTA	186	20,323
	10 20 30 40 50 60 MMSMDFEDFP VESAHRILTP RPTVMVTTVD EEGNINAAPF SFTMPVSIDP PVVAFASAPD 70 80 90 100 110 120 HHTARNIEST HEFVINITPA DIIERMWVTA RDIPAGENEL EAAGLAWTSS RRVKPPRIVE 130 140 150 160 170 180 APGHLECELL RMFEVGDHNL ITGSVVSASV RSGAVKEGLL DVESVKPVLH VGGNKFVVGD HVRHVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.
[2]	"Structural proteomics of an archaeon." Christendat D., Yee A., Dharamsi A., Kluger Y., Savchenko A., Cort J.R., Booth V., Mackereth C.D., Saridakis V., Ekiel I., Kozlov G., Maxwell K.L., Wu N., McIntosh L.P., Gehring K., Kennedy M.A., Davidson A.R., Pai E.F. , Gerstein M., Edwards A.M., Arrowsmith C.H. Nat. Struct. Biol. 7:903-909(2000) [PubMed: 11017201] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000666 Genomic DNA. Translation: AAB84658.1.

PIR

G69069.

RefSeq

NP_275295.1. NC_000916.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EJE	X-ray	2.20	A	1-186	[»]

ProteinModelPortal

O26255.

SMR

O26255. Positions 1-186.

ModBase

Search...

Protein-protein interaction databases

STRING

O26255.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1470113.

GenomeReviews

Gene locus MTH_152 in contig AE000666_GR.

KEGG

mth:MTH152.

NMPDR

fig|187420.1.peg.150.

Phylogenomic databases

eggNOG

arNOG07645.

HOGENOM

HBG644901.

OMA

HLECELL.

ProtClustDB

CLSK2750241.

Enzyme and pathway databases

BioCyc

MTHE187420:MTH152-MONOMER.

Family and domain databases

InterPro

IPR002563. Flavin_Rdtase_FMN-bd.
IPR012349. Split_barrel_FMN-bd.
IPR009002. Split_barrel_FMN-bd-related.
[Graphical view]

Gene3D

G3DSA:2.30.110.10. PNPOx_FMN_bd. 1 hit.

Pfam

PF01613. Flavin_Reduct. 1 hit.
[Graphical view]

SMART

SM00903. Flavin_Reduct. 1 hit.
[Graphical view]

SUPFAM

SSF50475. FMN_binding. 1 hit.

ProtoNet

Search...

Entry information

Entry name

P152_METTH

Accession

Primary (citable) accession number: O26255

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	January 1, 1998
Last modified:	October 19, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program