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O26237

- RISC_METTH

UniProt

O26237 - RISC_METTH

Protein

Riboflavin synthase

Gene

ribC

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Inhibited by EDTA.By similarity

    Pathwayi

    GO - Molecular functioni

    1. riboflavin synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-134-MONOMER.
    UniPathwayiUPA00275; UER00405.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin synthase (EC:2.5.1.9)
    Gene namesi
    Name:ribC
    Ordered Locus Names:MTH_134
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. riboflavin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Riboflavin synthasePRO_0000134861Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomer.By similarity

    Protein-protein interaction databases

    STRINGi187420.MTH134.

    Structurei

    3D structure databases

    ProteinModelPortaliO26237.
    SMRiO26237. Positions 3-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DMRL synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG1731.
    KOiK00793.
    OMAiGIVDTTF.

    Family and domain databases

    Gene3Di3.40.50.960. 1 hit.
    InterProiIPR002180. DMRL_synthase.
    IPR006399. Ribfl_synth_arc.
    [Graphical view]
    PfamiPF00885. DMRL_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
    SUPFAMiSSF52121. SSF52121. 1 hit.
    TIGRFAMsiTIGR01506. ribC_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O26237-1 [UniParc]FASTAAdd to Basket

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    MIKVGICDTT FARYDMGGAA IDELKKHTAG IKIIRRTVPG IKDLPVACKK    50
    LIEEEGCEMV MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH 100
    EDEEDDPEEL KVLADNRARE HAQNLIMMLF KPDRLTREAG MGLREGKPDA 150
    GPL 153
    Length:153
    Mass (Da):16,909
    Last modified:January 1, 1998 - v1
    Checksum:i79DD08CCBABBB785
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84640.1.
    PIRiB69045.
    RefSeqiNP_275277.1. NC_000916.1.
    WP_010875773.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB84640; AAB84640; MTH_134.
    GeneIDi1470095.
    KEGGimth:MTH134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84640.1 .
    PIRi B69045.
    RefSeqi NP_275277.1. NC_000916.1.
    WP_010875773.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O26237.
    SMRi O26237. Positions 3-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB84640 ; AAB84640 ; MTH_134 .
    GeneIDi 1470095.
    KEGGi mth:MTH134.

    Phylogenomic databases

    eggNOGi COG1731.
    KOi K00793.
    OMAi GIVDTTF.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00405 .
    BioCyci MTHE187420:GJNM-134-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.960. 1 hit.
    InterProi IPR002180. DMRL_synthase.
    IPR006399. Ribfl_synth_arc.
    [Graphical view ]
    Pfami PF00885. DMRL_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015750. Ribfl_synth_arc. 1 hit.
    SUPFAMi SSF52121. SSF52121. 1 hit.
    TIGRFAMsi TIGR01506. ribC_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiRISC_METTH
    AccessioniPrimary (citable) accession number: O26237
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3