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Protein

Riboflavin synthase

Gene

ribC

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Cofactori

Mg2+By similarity

Enzyme regulationi

Inhibited by EDTA.By similarity

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribC)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis
LigandMagnesium

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Gene namesi
Name:ribC
Ordered Locus Names:MTH_134
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001348611 – 153Riboflavin synthaseAdd BLAST153

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

STRINGi187420.MTH134

Structurei

3D structure databases

ProteinModelPortaliO26237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.Curated

Phylogenomic databases

eggNOGiarCOG01322 Archaea
COG1731 LUCA
KOiK00793
OMAiLMTNTHI
OrthoDBiPOG093Z0DB2

Family and domain databases

CDDicd09210 Riboflavin_synthase_archaeal, 1 hit
Gene3Di3.40.50.960, 1 hit
InterProiView protein in InterPro
IPR002180 LS/RS
IPR036467 LS/RS_sf
IPR006399 Ribfl_synth_arc
PfamiView protein in Pfam
PF00885 DMRL_synthase, 1 hit
PIRSFiPIRSF015750 Ribfl_synth_arc, 1 hit
SUPFAMiSSF52121 SSF52121, 1 hit
TIGRFAMsiTIGR01506 ribC_arch, 1 hit

Sequencei

Sequence statusi: Complete.

O26237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVGICDTT FARYDMGGAA IDELKKHTAG IKIIRRTVPG IKDLPVACKK
60 70 80 90 100
LIEEEGCEMV MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH
110 120 130 140 150
EDEEDDPEEL KVLADNRARE HAQNLIMMLF KPDRLTREAG MGLREGKPDA

GPL
Length:153
Mass (Da):16,909
Last modified:January 1, 1998 - v1
Checksum:i79DD08CCBABBB785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB84640.1
PIRiB69045

Genome annotation databases

EnsemblBacteriaiAAB84640; AAB84640; MTH_134
KEGGimth:MTH_134
PATRICifig|187420.15.peg.107

Similar proteinsi

Entry informationi

Entry nameiRISC_METTH
AccessioniPrimary (citable) accession number: O26237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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