O26237 (RISC_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin synthase
EC=2.5.1.9

Gene names

Name:	ribC
Ordered Locus Names:	MTH_134

Organism

Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) [Reference proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter › Methanobacterium thermoformicicum

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
Cofactor	Magnesium By similarity.
Enzyme regulation	Inhibited by EDTA By similarity.
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.
Subunit structure	Homooligomer By similarity.
Sequence similarities	Belongs to the DMRL synthase family.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Ligand	Magnesium
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	riboflavin synthase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	riboflavin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 153	153	Riboflavin synthase		PRO_0000134861

Sequences

	Sequence		Length	Mass (Da)
	O26237 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 79DD08CCBABBB785	FASTA	153	16,909
	10 20 30 40 50 60 MIKVGICDTT FARYDMGGAA IDELKKHTAG IKIIRRTVPG IKDLPVACKK LIEEEGCEMV 70 80 90 100 110 120 MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH EDEEDDPEEL KVLADNRARE 130 140 150 HAQNLIMMLF KPDRLTREAG MGLREGKPDA GPL

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB84640.1.
PIR	B69045.
RefSeq	NP_275277.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26237.
SMR	O26237. Positions 3-152.
ModBase	Search...
Protein-protein interaction databases
STRING	187420.MTH134.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB84640; AAB84640; MTH_134.
GeneID	1470095.
KEGG	mth:MTH134.
Phylogenomic databases
eggNOG	COG1731.
KO	K00793.
OMA	IVDTTFA.
ProtClustDB	PRK06455.
Enzyme and pathway databases
BioCyc	MTHE187420:GJNM-134-MONOMER.
UniPathway	UPA00275; UER00405.
Family and domain databases
Gene3D	3.40.50.960. 1 hit.
InterPro	IPR002180. DMRL_synthase. IPR006399. Ribfl_synth_arc. [Graphical view]
Pfam	PF00885. DMRL_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAM	SSF52121. DMRL_synthase. 1 hit.
TIGRFAMs	TIGR01506. ribC_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RISC_METTH

Accession

Primary (citable) accession number: O26237

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program