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O26237

- RISC_METTH

UniProt

O26237 - RISC_METTH

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Protein

Riboflavin synthase

Gene
ribC, MTH_134
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Inhibited by EDTA By similarity.

Pathwayi

GO - Molecular functioni

  1. riboflavin synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-134-MONOMER.
UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Gene namesi
Name:ribC
Ordered Locus Names:MTH_134
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Riboflavin synthasePRO_0000134861Add
BLAST

Interactioni

Subunit structurei

Homooligomer By similarity.

Protein-protein interaction databases

STRINGi187420.MTH134.

Structurei

3D structure databases

ProteinModelPortaliO26237.
SMRiO26237. Positions 3-152.

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.

Phylogenomic databases

eggNOGiCOG1731.
KOiK00793.
OMAiGIVDTTF.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
InterProiIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR01506. ribC_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

O26237-1 [UniParc]FASTAAdd to Basket

« Hide

MIKVGICDTT FARYDMGGAA IDELKKHTAG IKIIRRTVPG IKDLPVACKK    50
LIEEEGCEMV MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH 100
EDEEDDPEEL KVLADNRARE HAQNLIMMLF KPDRLTREAG MGLREGKPDA 150
GPL 153
Length:153
Mass (Da):16,909
Last modified:January 1, 1998 - v1
Checksum:i79DD08CCBABBB785
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84640.1.
PIRiB69045.
RefSeqiNP_275277.1. NC_000916.1.
WP_010875773.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84640; AAB84640; MTH_134.
GeneIDi1470095.
KEGGimth:MTH134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB84640.1 .
PIRi B69045.
RefSeqi NP_275277.1. NC_000916.1.
WP_010875773.1. NC_000916.1.

3D structure databases

ProteinModelPortali O26237.
SMRi O26237. Positions 3-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84640 ; AAB84640 ; MTH_134 .
GeneIDi 1470095.
KEGGi mth:MTH134.

Phylogenomic databases

eggNOGi COG1731.
KOi K00793.
OMAi GIVDTTF.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00405 .
BioCyci MTHE187420:GJNM-134-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
InterProi IPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view ]
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR01506. ribC_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiRISC_METTH
AccessioniPrimary (citable) accession number: O26237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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