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O26237 (RISC_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Cofactor

Magnesium By similarity.

Enzyme regulation

Inhibited by EDTA By similarity.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.

Subunit structure

Homooligomer By similarity.

Sequence similarities

Belongs to the DMRL synthase family.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   LigandMagnesium
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processriboflavin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentriboflavin synthase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionriboflavin synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Riboflavin synthase
PRO_0000134861

Sequences

Sequence LengthMass (Da)Tools
O26237 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 79DD08CCBABBB785

FASTA15316,909
        10         20         30         40         50         60 
MIKVGICDTT FARYDMGGAA IDELKKHTAG IKIIRRTVPG IKDLPVACKK LIEEEGCEMV 

        70         80         90        100        110        120 
MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH EDEEDDPEEL KVLADNRARE 

       130        140        150 
HAQNLIMMLF KPDRLTREAG MGLREGKPDA GPL 

« Hide

References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000666 Genomic DNA. Translation: AAB84640.1.
PIRB69045.
RefSeqNP_275277.1. NC_000916.1.

3D structure databases

ProteinModelPortalO26237.
SMRO26237. Positions 3-152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING187420.MTH134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB84640; AAB84640; MTH_134.
GeneID1470095.
KEGGmth:MTH134.

Phylogenomic databases

eggNOGCOG1731.
KOK00793.
OMAGIVDTTF.

Enzyme and pathway databases

BioCycMTHE187420:GJNM-134-MONOMER.
UniPathwayUPA00275; UER00405.

Family and domain databases

Gene3D3.40.50.960. 1 hit.
InterProIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMSSF52121. SSF52121. 1 hit.
TIGRFAMsTIGR01506. ribC_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRISC_METTH
AccessionPrimary (citable) accession number: O26237
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways