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Protein

Riboflavin synthase

Gene

ribC

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Cofactori

Mg2+By similarity

Enzyme regulationi

Inhibited by EDTA.By similarity

Pathway:iriboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribC)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-134-MONOMER.
UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Gene namesi
Name:ribC
Ordered Locus Names:MTH_134
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Riboflavin synthasePRO_0000134861Add
BLAST

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

STRINGi187420.MTH134.

Structurei

3D structure databases

ProteinModelPortaliO26237.
SMRiO26237. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.Curated

Phylogenomic databases

eggNOGiCOG1731.
KOiK00793.
OMAiGIVDTTF.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
InterProiIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR01506. ribC_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

O26237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVGICDTT FARYDMGGAA IDELKKHTAG IKIIRRTVPG IKDLPVACKK
60 70 80 90 100
LIEEEGCEMV MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH
110 120 130 140 150
EDEEDDPEEL KVLADNRARE HAQNLIMMLF KPDRLTREAG MGLREGKPDA

GPL
Length:153
Mass (Da):16,909
Last modified:January 1, 1998 - v1
Checksum:i79DD08CCBABBB785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84640.1.
PIRiB69045.
RefSeqiNP_275277.1. NC_000916.1.
WP_010875773.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84640; AAB84640; MTH_134.
GeneIDi1470095.
KEGGimth:MTH134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84640.1.
PIRiB69045.
RefSeqiNP_275277.1. NC_000916.1.
WP_010875773.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO26237.
SMRiO26237. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84640; AAB84640; MTH_134.
GeneIDi1470095.
KEGGimth:MTH134.

Phylogenomic databases

eggNOGiCOG1731.
KOiK00793.
OMAiGIVDTTF.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.
BioCyciMTHE187420:GJNM-134-MONOMER.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
InterProiIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR01506. ribC_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiRISC_METTH
AccessioniPrimary (citable) accession number: O26237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.