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Protein

Archaeal glutamate synthase [NADPH]

Gene

MTH_105

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH.UniRule annotation

Cofactori

FMNUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Glutamate biosynthesisUniRule annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Flavoprotein, FMNUniRule annotation, Iron, Iron-sulfur, Metal-binding, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Archaeal glutamate synthase [NADPH]UniRule annotation (EC:1.4.1.13UniRule annotation)
Gene namesi
Ordered Locus Names:MTH_105Imported
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)Imported
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH105.

Structurei

3D structure databases

ProteinModelPortaliO26208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 27224Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini70 – 99304Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini161 – 190304Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini191 – 219294Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST
Domaini530 – 559304Fe-4S ferredoxin-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutamate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00619. Archaea.
arCOG01502. Archaea.
COG0069. LUCA.
COG1142. LUCA.
OMAiGASRPYY.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR013785. Aldolase_TIM.
IPR024188. GltB.
IPR002932. Glu_synthdom.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF12838. Fer4_7. 1 hit.
PF01645. Glu_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF006429. GOGAT_lg_2. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 4 hits.
PS51379. 4FE4S_FER_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHMVQILLT EPEKCDGCNK CLEACESVLG RSAIFLNKMD TGYHAIVCQQ
60 70 80 90 100
CVDPSCARGC FRDAIRRENG AVKIDQESCV GCKLCMLMCP IGAITYTDEG
110 120 130 140 150
MVKCDQQCIE KPGDTPACVA ACEQGCLEAL DVMEYVNDIQ RGFEIKTPST
160 170 180 190 200
GSITPSSPSS DLAAATQGLC VFCGTCEIVC PTDAIKIVED HAEIDKTKCI
210 220 230 240 250
MCGSCLAACP VLIPTGAGSI WDPRTIADIR YTSKAGKYVL RGFGTERRLP
260 270 280 290 300
NFDDIIILPA QASIPPVDKY REPCNTSVVL GDRFAEEPLV LQTPVLIAGM
310 320 330 340 350
SFGALSKESK LAMAKGSSMV GSCANTGEGG MLPEERELAD NLMVQYSSGR
360 370 380 390 400
FGVSSDYLNV ADAIEVKIGQ GAKPGMGGHL LAEKVSPEVA KIRGIPEGTD
410 420 430 440 450
ALSPARFLDA TREGDLAKHI ELLREVTDWR VPIVVKLGPG RVYEDVQIAA
460 470 480 490 500
EAGADVISVD GMEGGTGAAP EVVIEHTGVP TLAALVQAVN GLNDIGLKDE
510 520 530 540 550
VDLIITGGIR SGADVAKAMA MGADAVYIGT GAMIAMGCRA CRMCYTGKCP
560 570 580 590 600
VGVATQDPVL RERMDVDLAA RRVANYIKSM TEEAKMLAQL AGHDDIRKFS
610 620
PEDLRALDTN TAAITGLKLI NQ
Length:622
Mass (Da):66,048
Last modified:January 1, 1998 - v1
Checksum:iF6F9A7FE4022C3D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84604.1.
PIRiE69006.

Genome annotation databases

EnsemblBacteriaiAAB84604; AAB84604; MTH_105.
KEGGimth:MTH_105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84604.1.
PIRiE69006.

3D structure databases

ProteinModelPortaliO26208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84604; AAB84604; MTH_105.
KEGGimth:MTH_105.

Phylogenomic databases

eggNOGiarCOG00619. Archaea.
arCOG01502. Archaea.
COG0069. LUCA.
COG1142. LUCA.
OMAiGASRPYY.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-105-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR013785. Aldolase_TIM.
IPR024188. GltB.
IPR002932. Glu_synthdom.
[Graphical view]
PfamiPF00037. Fer4. 1 hit.
PF12838. Fer4_7. 1 hit.
PF01645. Glu_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF006429. GOGAT_lg_2. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 4 hits.
PS51379. 4FE4S_FER_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta HImported.

Entry informationi

Entry nameiO26208_METTH
AccessioniPrimary (citable) accession number: O26208
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.