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Protein

Aquaporin AqpM

Gene

aqpM

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin AqpM
Gene namesi
Name:aqpM
Ordered Locus Names:MTH_103
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 4513ExtracellularSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Topological domaini67 – 693CytoplasmicSequence analysis
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 10313ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Topological domaini125 – 14521CytoplasmicSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Topological domaini167 – 1726ExtracellularSequence analysis
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Topological domaini194 – 21724CytoplasmicSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Topological domaini239 – 2468ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Aquaporin AqpMPRO_0000064005Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi187420.MTH103.

Structurei

3D structure databases

ProteinModelPortaliO26206.
SMRiO26206. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi82 – 843NPA 1
Motifi199 – 2013NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG04431. Archaea.
COG0580. LUCA.
KOiK02440.
OMAiYADHSPG.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 2 hits.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLTKRCIA EFIGTFFLVF FGAGAAAITL MIASGGTAPN PFNIGIGLLG
60 70 80 90 100
GLGDWVAIGL AFGFAIAASI YALGNISGCH INPAVTIGLW SVKKFPGRDV
110 120 130 140 150
VPYIIAQLLG AAFASFIFLQ CAGITAATIG GLGATAPFPG IGYWQAMLAE
160 170 180 190 200
TVGTFLLMIT IMGIAVDERA PKGFAGIIIG LTVAGIITTI GNITGSSLNP
210 220 230 240
ARTFGPYLND MVFAGTNLWN YFPIYVIGPV VGAVLAALTY QYLTSE
Length:246
Mass (Da):25,373
Last modified:January 1, 1998 - v1
Checksum:iF2F2E2B9233B8239
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84602.1.
PIRiD69004.
RefSeqiWP_010875742.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84602; AAB84602; MTH_103.
GeneIDi1470064.
KEGGimth:MTH_103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84602.1.
PIRiD69004.
RefSeqiWP_010875742.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO26206.
SMRiO26206. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB84602; AAB84602; MTH_103.
GeneIDi1470064.
KEGGimth:MTH_103.

Phylogenomic databases

eggNOGiarCOG04431. Archaea.
COG0580. LUCA.
KOiK02440.
OMAiYADHSPG.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-103-MONOMER.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 2 hits.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQPM_METTH
AccessioniPrimary (citable) accession number: O26206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.