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O26157

- SYE_METTH

UniProt

O26157 - SYE_METTH

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-51-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:MTH_51
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Glutamate--tRNA ligasePRO_0000119721Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH51.

Structurei

Secondary structure

1
553
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi98 – 1014Combined sources
Beta strandi105 – 1084Combined sources
Helixi111 – 12616Combined sources
Beta strandi130 – 1356Combined sources
Helixi140 – 1423Combined sources
Helixi147 – 15812Combined sources
Beta strandi163 – 1675Combined sources
Helixi168 – 1714Combined sources
Helixi172 – 18413Combined sources
Beta strandi187 – 1915Combined sources
Helixi195 – 2039Combined sources
Helixi209 – 2124Combined sources
Helixi215 – 22410Combined sources
Helixi225 – 2273Combined sources
Beta strandi234 – 2374Combined sources
Helixi246 – 2483Combined sources
Beta strandi252 – 2565Combined sources
Turni262 – 2643Combined sources
Beta strandi270 – 2723Combined sources
Helixi274 – 28411Combined sources
Beta strandi289 – 2924Combined sources
Helixi299 – 31012Combined sources
Beta strandi316 – 3194Combined sources
Helixi333 – 3419Combined sources
Helixi355 – 3606Combined sources
Helixi365 – 37511Combined sources
Helixi386 – 39712Combined sources
Turni398 – 4003Combined sources
Beta strandi402 – 4043Combined sources
Beta strandi406 – 41611Combined sources
Beta strandi422 – 4287Combined sources
Helixi433 – 4353Combined sources
Beta strandi437 – 44913Combined sources
Beta strandi455 – 4606Combined sources
Turni461 – 4633Combined sources
Beta strandi464 – 4696Combined sources
Beta strandi472 – 4776Combined sources
Helixi480 – 4867Combined sources
Beta strandi489 – 4913Combined sources
Helixi496 – 4983Combined sources
Beta strandi500 – 5056Combined sources
Beta strandi511 – 5166Combined sources
Helixi518 – 5225Combined sources
Beta strandi528 – 5314Combined sources
Turni532 – 5343Combined sources
Beta strandi535 – 5417Combined sources
Beta strandi543 – 55210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AIIX-ray1.65A1-553[»]
ProteinModelPortaliO26157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi103 – 11311"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
KOiK01885.
OMAiYLGWDDP.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O26157-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPVEDLVYR YALLNAVKHR GRANPGAVMG AVMSNEPELR KMAPQVKEAV
60 70 80 90 100
EAAVERVNSL SPEEQQQEME RLGLEITERK QKKRKGLREL AGVKGEVVLR
110 120 130 140 150
FAPNPSGPLH IGHARAAILN HEYARKYDGR LILRIEDTDP RRVDPEAYDM
160 170 180 190 200
IPADLEWLGV EWDETVIQSD RMETYYEYTE KLIERGGAYV CTCRPEEFRE
210 220 230 240 250
LKNRGEACHC RSLGFRENLQ RWREMFEMKE GSAVVRVKTD LNHPNPAIRD
260 270 280 290 300
WVSMRIVEAE HPRTGTRYRV YPMMNFSVAV DDHLLGVTHV LRGKDHLANR
310 320 330 340 350
EKQEYLYRHL GWEPPEFIHY GRLKMDDVAL STSGAREGIL RGEYSGWDDP
360 370 380 390 400
RLGTLRAIAR RGIRPEAIRK LMVEIGVKIA DSTMSWKKIY GLNRSILEEE
410 420 430 440 450
ARRYFFAADP VKLEVVGLPG PVRVERPLHP DHPEIGNRVL ELRGEVYLPG
460 470 480 490 500
DDLGEGPLRL IDAVNVIYSG GELRYHSEGI EEARELGASM IHWVPAESAL
510 520 530 540 550
EAEVIMPDAS RVRGVIEADA SELEVDDVVQ LERFGFARLD SAGPGMVFYY

AHK
Length:553
Mass (Da):63,090
Last modified:January 1, 1998 - v1
Checksum:iC6DB8AE92C2FEE6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84558.1.
PIRiB69167.
RefSeqiNP_275194.1. NC_000916.1.
WP_010875691.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB84558; AAB84558; MTH_51.
GeneIDi1470013.
KEGGimth:MTH51.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB84558.1 .
PIRi B69167.
RefSeqi NP_275194.1. NC_000916.1.
WP_010875691.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AII X-ray 1.65 A 1-553 [» ]
ProteinModelPortali O26157.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH51.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB84558 ; AAB84558 ; MTH_51 .
GeneIDi 1470013.
KEGGi mth:MTH51.

Phylogenomic databases

eggNOGi COG0008.
KOi K01885.
OMAi YLGWDDP.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-51-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiSYE_METTH
AccessioniPrimary (citable) accession number: O26157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3