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O26157

- SYE_METTH

UniProt

O26157 - SYE_METTH

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-51-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:MTH_51
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Glutamate--tRNA ligasePRO_0000119721Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH51.

    Structurei

    Secondary structure

    1
    553
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi98 – 1014
    Beta strandi105 – 1084
    Helixi111 – 12616
    Beta strandi130 – 1356
    Helixi140 – 1423
    Helixi147 – 15812
    Beta strandi163 – 1675
    Helixi168 – 1714
    Helixi172 – 18413
    Beta strandi187 – 1915
    Helixi195 – 2039
    Helixi209 – 2124
    Helixi215 – 22410
    Helixi225 – 2273
    Beta strandi234 – 2374
    Helixi246 – 2483
    Beta strandi252 – 2565
    Turni262 – 2643
    Beta strandi270 – 2723
    Helixi274 – 28411
    Beta strandi289 – 2924
    Helixi299 – 31012
    Beta strandi316 – 3194
    Helixi333 – 3419
    Helixi355 – 3606
    Helixi365 – 37511
    Helixi386 – 39712
    Turni398 – 4003
    Beta strandi402 – 4043
    Beta strandi406 – 41611
    Beta strandi422 – 4287
    Helixi433 – 4353
    Beta strandi437 – 44913
    Beta strandi455 – 4606
    Turni461 – 4633
    Beta strandi464 – 4696
    Beta strandi472 – 4776
    Helixi480 – 4867
    Beta strandi489 – 4913
    Helixi496 – 4983
    Beta strandi500 – 5056
    Beta strandi511 – 5166
    Helixi518 – 5225
    Beta strandi528 – 5314
    Turni532 – 5343
    Beta strandi535 – 5417
    Beta strandi543 – 55210

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AIIX-ray1.65A1-553[»]
    ProteinModelPortaliO26157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi103 – 11311"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    KOiK01885.
    OMAiYLGWDDP.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O26157-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPVEDLVYR YALLNAVKHR GRANPGAVMG AVMSNEPELR KMAPQVKEAV    50
    EAAVERVNSL SPEEQQQEME RLGLEITERK QKKRKGLREL AGVKGEVVLR 100
    FAPNPSGPLH IGHARAAILN HEYARKYDGR LILRIEDTDP RRVDPEAYDM 150
    IPADLEWLGV EWDETVIQSD RMETYYEYTE KLIERGGAYV CTCRPEEFRE 200
    LKNRGEACHC RSLGFRENLQ RWREMFEMKE GSAVVRVKTD LNHPNPAIRD 250
    WVSMRIVEAE HPRTGTRYRV YPMMNFSVAV DDHLLGVTHV LRGKDHLANR 300
    EKQEYLYRHL GWEPPEFIHY GRLKMDDVAL STSGAREGIL RGEYSGWDDP 350
    RLGTLRAIAR RGIRPEAIRK LMVEIGVKIA DSTMSWKKIY GLNRSILEEE 400
    ARRYFFAADP VKLEVVGLPG PVRVERPLHP DHPEIGNRVL ELRGEVYLPG 450
    DDLGEGPLRL IDAVNVIYSG GELRYHSEGI EEARELGASM IHWVPAESAL 500
    EAEVIMPDAS RVRGVIEADA SELEVDDVVQ LERFGFARLD SAGPGMVFYY 550
    AHK 553
    Length:553
    Mass (Da):63,090
    Last modified:January 1, 1998 - v1
    Checksum:iC6DB8AE92C2FEE6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84558.1.
    PIRiB69167.
    RefSeqiNP_275194.1. NC_000916.1.
    WP_010875691.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB84558; AAB84558; MTH_51.
    GeneIDi1470013.
    KEGGimth:MTH51.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB84558.1 .
    PIRi B69167.
    RefSeqi NP_275194.1. NC_000916.1.
    WP_010875691.1. NC_000916.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AII X-ray 1.65 A 1-553 [» ]
    ProteinModelPortali O26157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB84558 ; AAB84558 ; MTH_51 .
    GeneIDi 1470013.
    KEGGi mth:MTH51.

    Phylogenomic databases

    eggNOGi COG0008.
    KOi K01885.
    OMAi YLGWDDP.

    Enzyme and pathway databases

    BioCyci MTHE187420:GJNM-51-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiSYE_METTH
    AccessioniPrimary (citable) accession number: O26157
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3