O26154 (IDI2_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2

Alternative name(s):
Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	MTH_48

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00354
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354
Cofactor	FMN By similarity. HAMAP MF_00354 NADPH By similarity. HAMAP MF_00354
Subcellular location	Cytoplasm By similarity HAMAP MF_00354.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: EC oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354		PRO_0000134447

Sequences

	Sequence		Length	Mass (Da)
	O26154 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A73915E8EE5B3A1E	FASTA	349	37,142
	10 20 30 40 50 60 MISDRKLEHL ILCASCDVEY RKKTGFEDIE IVHRAIPEIN KEKIDISLDF LGRELSSPVM 70 80 90 100 110 120 ISAITGGHPA SMKINRELAR AAEKLGIALG LGSQRAGVEH PELEGTYTIA REEAPSAMLI 130 140 150 160 170 180 GNIGSSHIEY AERAVEMIDA DALAVHLNPL QESIQPGGDV DSSGALESIS AIVESVDVPV 190 200 210 220 230 240 MVKETGAGIC SEDAIELESC GVSAIDVAGA GGTSWAAVET YRADDRYLGE LFWDWGIPTA 250 260 270 280 290 300 ASTVEVVESV SIPVIASGGI RSGIDAAKAI SLGAEMVGIA LPVLEAAGHG YREVIKVIEG 310 320 330 340 FNEALRTAMY LAGAETLDDL KKSPVIITGH TGEWLNQRGF ETKKYARRS

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB84555.1.
PIR	H69162.
RefSeq	NP_275191.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26154.
ModBase	Search...
Protein-protein interaction databases
STRING	O26154.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470010.
GenomeReviews	Gene locus MTH_48 in contig AE000666_GR.
KEGG	mth:MTH48.
NMPDR	fig|187420.1.peg.46.
Phylogenomic databases
eggNOG	arNOG04310.
HOGENOM	HBG354479.
OMA	GSQRAAI.
ProtClustDB	PRK05437.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH48-MONOMER.
Family and domain databases
HAMAP	MF_00354. Idi_2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01823.
PANTHER	PTHR10578:SF3. IPdP_isomerase. 1 hit.
Pfam	PF01070. FMN_dh. 2 hits. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_METTH

Accession

Primary (citable) accession number: O26154

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program