O26148 (RPOK_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit K
EC=2.7.7.6

Gene names

Name:	rpoK
Ordered Locus Names:	MTH_42

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_00192
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_00192
Sequence similarities	Belongs to the archaeal rpoK/eukaryotic RPB6 RNA polymerase subunit family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	RNA polymerase complex Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 61	61	DNA-directed RNA polymerase subunit K HAMAP MF_00192		PRO_0000133815

Sequences

	Sequence		Length	Mass (Da)
	O26148 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 65B6E22FDA480E7B	FASTA	61	7,043
	10 20 30 40 50 60 MHMASKKLTR FERARLIGAR ALQISMGARP LVEIKESLDP VDIARKELEK KVMPLDVRRD K

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB84549.1.
PIR	F69154.
RefSeq	NP_275185.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O26148.
ModBase	Search...
Protein-protein interaction databases
STRING	O26148.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470004.
GenomeReviews	Gene locus MTH_42 in contig AE000666_GR.
KEGG	mth:MTH42.
NMPDR	fig|187420.1.peg.40.
Phylogenomic databases
eggNOG	arNOG14104.
HOGENOM	HBG646526.
OMA	FRYTRFE.
ProtClustDB	PRK01099.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH42-MONOMER.
Family and domain databases
HAMAP	MF_00192. RNApol_arch_K. [Tree]
InterPro	IPR020708. DNA-dir_RNA_polK_14-18kDa_CS. IPR006111. DNA-dir_RNA_polK_K/RPABC2. IPR006110. RNA_poly_omega/K/RPABC2. IPR012293. RNAP_RPB6_omega. [Graphical view]
Gene3D	G3DSA:3.90.940.10. RNAP_RPB6_omega. 1 hit.
KO	K03055.
PANTHER	PTHR10773. RNA_polK_14kDa. 1 hit.
Pfam	PF01192. RNA_pol_Rpb6. 1 hit. [Graphical view]
PIRSF	PIRSF000778. RpoK/RPB6. 1 hit.
SUPFAM	SSF63562. RNA_pol_omega. 1 hit.
PROSITE	PS01111. RNA_POL_K_14KD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPOK_METTH

Accession

Primary (citable) accession number: O26148

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program